Assembly of the monomeric PGN:PGRP-LE oligomer receptor 'signalling complex'

Stable Identifier
Reaction [binding]
Drosophila melanogaster
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Upon monomeric peptidoglycan (PGN) binding and receptor multimerisation in the cytosol, a 'signalling complex' is assembled. The adaptor protein, IMD, binds to the PGRP-LE receptors, while another adaptor protein, DFADD (BG4), binds to IMD through their respective death domains. The caspase-8 orthologue, DREDD, binds to BG4 through interaction between their respective death-inducing (DID) domains.

Literature References
PubMed ID Title Journal Year
16767093 PGRP-LC and PGRP-LE have essential yet distinct functions in the drosophila immune response to monomeric DAP-type peptidoglycan

Yano, T, Kaneko, T, Silverman, N, Lim, JH, Kurata, S, Peach, C, Oshima, Y, Aggarwal, K, Goldman, WE, Ueda, K, Erturk-Hasdemir, D, Oh, BH

Nat Immunol 2006
10934188 dFADD, a novel death domain-containing adapter protein for the Drosophila caspase DREDD

Hu, S, Yang, X

J Biol Chem 2000
12433364 The Drosophila immune defense against gram-negative infection requires the death protein dFADD

Belvin, M, Georgel, P, Kappler, C, Rosse, C, Naitza, S, Reichhart, JM, Camonis, J, Gubb, D, Hoffmann, JA

Immunity 2002
16428381 Structural basis for preferential recognition of diaminopimelic acid-type peptidoglycan by a subset of peptidoglycan recognition proteins

Yano, T, Silverman, N, Lim, JH, Kurata, S, Oshima, Y, Kim, HE, Aggarwal, K, Goldman, WE, Kim, MS, Oh, BH

J Biol Chem 2006
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