Upon monomeric peptidoglycan (PGN) binding and receptor multimerisation in the cytosol, a 'signalling complex' is assembled. The adaptor protein, IMD, binds to the PGRP-LE receptors, while another adaptor protein, DFADD (BG4), binds to IMD through their respective death domains. The caspase-8 orthologue, DREDD, binds to BG4 through interaction between their respective death-inducing (DID) domains.
Yano, T, Kaneko, T, Silverman, N, Lim, JH, Kurata, S, Peach, C, Oshima, Y, Aggarwal, K, Goldman, WE, Ueda, K, Erturk-Hasdemir, D, Oh, BH
Hu, S, Yang, X
Belvin, M, Georgel, P, Kappler, C, Rosse, C, Naitza, S, Reichhart, JM, Camonis, J, Gubb, D, Hoffmann, JA
Yano, T, Silverman, N, Lim, JH, Kurata, S, Oshima, Y, Kim, HE, Aggarwal, K, Goldman, WE, Kim, MS, Oh, BH
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