Reactome | Assembly of the monomeric PGN:PGRP-LE oligomer receptor 'signalling complex'

Assembly of the monomeric PGN:PGRP-LE oligomer receptor 'signalling complex'

Stable Identifier

R-DME-214405

Type

Reaction [binding]

Species

Drosophila melanogaster

Compartment

cytosol

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Assembly of the monomeric PGN:PGRP-LE oligomer receptor 'signalling complex'

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Upon monomeric peptidoglycan (PGN) binding and receptor multimerisation in the cytosol, a 'signalling complex' is assembled. The adaptor protein, IMD, binds to the PGRP-LE receptors, while another adaptor protein, DFADD (BG4), binds to IMD through their respective death domains. The caspase-8 orthologue, DREDD, binds to BG4 through interaction between their respective death-inducing (DID) domains.

Literature References

PubMed ID	Title	Journal	Year
16767093	PGRP-LC and PGRP-LE have essential yet distinct functions in the drosophila immune response to monomeric DAP-type peptidoglycan Yano, T, Kaneko, T, Silverman, N, Lim, JH, Kurata, S, Peach, C, Oshima, Y, Aggarwal, K, Goldman, WE, Ueda, K, Erturk-Hasdemir, D, Oh, BH	Nat Immunol	2006
10934188	dFADD, a novel death domain-containing adapter protein for the Drosophila caspase DREDD Hu, S, Yang, X	J Biol Chem	2000
12433364	The Drosophila immune defense against gram-negative infection requires the death protein dFADD Belvin, M, Georgel, P, Kappler, C, Rosse, C, Naitza, S, Reichhart, JM, Camonis, J, Gubb, D, Hoffmann, JA	Immunity	2002
16428381	Structural basis for preferential recognition of diaminopimelic acid-type peptidoglycan by a subset of peptidoglycan recognition proteins Yano, T, Silverman, N, Lim, JH, Kurata, S, Oshima, Y, Kim, HE, Aggarwal, K, Goldman, WE, Kim, MS, Oh, BH	J Biol Chem	2006