Phosphorylated REL is cleaved by and dissociates from DREDD in the monomeric PGN:PGRP-LE oligomer receptor 'signalling complex'

Stable Identifier
R-DME-214393
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
ReviewStatus
5/5
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Phosphorylated Relish (REL) is endoproteolytically cleaved by the caspase-8 orthologue, DREDD, between residues Asp545 and Gly546 at a consensus target site for group III caspases found in the interdomain linker. The two cleavage products, REL-68 and REL-49, dissociate from DREDD.
Literature References
PubMed ID Title Journal Year
12732719 Caspase-mediated processing of the Drosophila NF-kappaB factor Relish

Erturk, D, Hedengren-Olcott, M, Silverman, N, Engstrom, Y, Junell, A, Hultmark, D, Maniatis, T, Stoven, S

Proc Natl Acad Sci U S A 2003
Participants
Participates
Catalyst Activity

cysteine-type endopeptidase activity of DREDD [cytosol]

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Reviewed
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