Reactome | Su(z)12 [nucleoplasm]

Su(z)12 [nucleoplasm]

Stable Identifier

R-DME-212217

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

nucleoplasm

Synonyms

SUZ12, Q9NJG9

Locations in the PathwayBrowser

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Signal Transduction (Drosophila melanogaster)

- Intracellular signaling by second messengers (Drosophila melanogaster)
  - PIP3 activates AKT signaling (Drosophila melanogaster)
    - PTEN Regulation (Drosophila melanogaster)
      - Regulation of PTEN gene transcription (Drosophila melanogaster)
        
        MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Drosophila melanogaster)
        
        MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene [nucleoplasm] (Drosophila melanogaster)
        
        MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Drosophila melanogaster)
        
        PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Drosophila melanogaster)
        
        PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
        
        Su(z)12 [nucleoplasm] (Drosophila melanogaster)
        
        PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Drosophila melanogaster)
        
        PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)
        
        Su(z)12 [nucleoplasm] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q9NJG9

Gene Names

Su(z)12

Reference Genes

BioGPS Gene:48071 Su(z)12

CTD Gene:48071 Su(z)12

ENSEMBL:FBgn0020887

Flybase:FBgn0020887

KEGG Gene (Drosophila melanogaster):Dmel_CG8013 Su(z)12

Monarch:48071 Su(z)12

NCBI Gene:48071 Su(z)12

Reference Transcript

Other Identifiers

141612_at

1623952_a_at

48071

GO:0000785

GO:0003677

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0016586

GO:0022008

GO:0030154

GO:0031490

GO:0031491

GO:0035097

GO:0035098

GO:0043226

GO:0045892

GO:0046872

GO:0048856

GO:0140718

GO:2001229

Participates

as an input of

Formation of PRC2-EZH2 complex (Drosophila melanogaster)

as a component of

PRC2 (EZH2) Core [nucleoplasm] (Drosophila melanogaster)

Inferred From

SUZ12 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_730465.1, NP_652059.1

Flybase

FBgn0020887

PRO

Q9NJG9

PDB

2YB8

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q24338 ESC			0.69	5
UniProt:Q24459 PCL			0.69	4
UniProt:P42124	1	E(z) [nucleoplasm] (R-DME-212298)	0.527	2

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