KEN dimer represses transcription

Stable Identifier
R-DME-210700
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
ReviewStatus
5/5
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In the nucleus, the BCL6 orthologue, Ken and Barbie (KEN) dimer binds to GAAA sequences of the target gene DNA sequence. These overlap with some STAT92E binding sites and leads to transcription repression.
Literature References
PubMed ID Title Journal Year
9770450 Crystal structure of the BTB domain from PLZF

Privé, GG, Ahmad, KF, Engel, CK

Proc Natl Acad Sci U S A 1998
15659391 Repression of an interleukin-4-responsive promoter requires cooperative BCL-6 function

Mostecki, J, Harris, MB, Rothman, PB

J Biol Chem 2005
16401426 Ken & barbie selectively regulates the expression of a subset of Jak/STAT pathway target genes

Bach, EA, Arbouzova, NI, Zeidler, MP

Curr Biol 2006
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