N-HH is palmitoylated by RASP

Stable Identifier
R-DME-209357
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
cytosol
ReviewStatus
5/5
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N-HH is palmitoylated by RASP
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After removal of an N-terminal signal sequence, RASP, a protein-cysteine N-palmitoyltransferase, palmitoylates the new N-terminus (CGPGR..) via a thiol intermediate that resolves into a stable amide linkage. Palmitoylation efficiency is increased by prior addition of cholesterol at the C-terminus.
Literature References
PubMed ID Title Journal Year
15189162 Novel lipid modifications of secreted protein signals

Beachy, PA, Mann, RK

Annu Rev Biochem 2004
11861468 Rasp, a putative transmembrane acyltransferase, is required for Hedgehog signaling

Mogila, V, Micchelli, CA, Selva, E, The, I, Perrimon, N

Development 2002
11486055 Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal

Beachy, PA, Bellotto, M, Nellen, D, Chamoun, Z, von Kessler, DP, Mann, RK, Basler, K

Science 2001
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Catalyst Activity

palmitoyltransferase activity of RASP [cytosol]

Physical Entity
RASP [cytosol] (Drosophila melanogaster)
Activity
palmitoyltransferase activity (GO:0016409)
Authored
Williams, MG  (2006-12-07)
Reviewed
Kalderon, D  (2008-03-17)
Created
Williams, MG  (2006-12-08)
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