Phosphorylated REL-68 forms a complex with PCAF at its target gene and activates transcription

Stable Identifier
R-DME-209257
Type
Reaction [binding]
Species
Drosophila melanogaster
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Phosphorylated REL-68 forms a complex with PCAF at its target gene and activates transcription
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
In the nucleus, phosphorylated Relish (REL-68) forms a complex with the histone acetyltransferase, PCAF, at its target gene and transcription is activated.
Literature References
PubMed ID Title Journal Year
15640802 Downregulation of lipopolysaccharide response in Drosophila by negative crosstalk between the AP1 and NF-kappaB signaling modules

Kim, YJ, Kim, J, Kim, T, Yoon, J, Yoon, JH, Song, YH, Kim-Ha, J, Lee, WB, Cho, H, Kim, SN

Nat Immunol 2005
17803358 Down-regulation of NF-kappaB target genes by the AP-1 and STAT complex during the innate immune response in Drosophila

Kim, YJ, Shim, J, Cho, HS, Kim, J, Kim, LK, Choi, UY, Kim-Ha, J, Lee, WB, Lee, JS, Jeong, K

PLoS Biol 2007
10409696 Interaction and specificity of Rel-related proteins in regulating Drosophila immunity gene expression

Ip, YT, Han, ZS

J Biol Chem 1999
11269501 Activation of the Drosophila NF-kappaB factor Relish by rapid endoproteolytic cleavage

Ando, I, Engstrom, Y, Kadalayil, L, Hultmark, D, Stoven, S

EMBO Rep 2000
12732719 Caspase-mediated processing of the Drosophila NF-kappaB factor Relish

Erturk, D, Hedengren-Olcott, M, Silverman, N, Engstrom, Y, Junell, A, Hultmark, D, Maniatis, T, Stoven, S

Proc Natl Acad Sci U S A 2003
Participants
Input
Output
Participates
as an event of
Authored
Williams, MG  (2007-07-11)
Reviewed
Lemaitre, B  (2008-06-20)
Silverman, N  (2008-06-20)
Created
Williams, MG  (2007-07-12)
Cite Us!