Phosphorylation of CI by SGG

Stable Identifier
R-DME-209172
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
cytosol
ReviewStatus
5/5
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Phosphorylation of CI by SGG
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Previous phosphorylation of Cubitus Interruptus (CI) at Ser856 and Ser892 primes Shaggy (SGG) phosphorylation at Ser884 and Ser888. Ser852 can also be phosphorylated by SGG if it hasn't been previously phosphorylated by CKIalpha/DCO.
Literature References
PubMed ID Title Journal Year
16326393 Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing

Tong, C, Hou, F, Wang, B, Jiang, J, Zhang, L, Jia, J, Amanai, K, Zhang, Q

Dev Cell 2005
11912487 Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus

Wang, G, Tang, J, Wang, B, Jiang, J, Jia, J, Amanai, K

Nature 2002
11955435 Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1

Price, MA, Kalderon, D

Cell 2002
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of Phospho AXN:Phospho APC:PP2A:CKIalpha:DCO:SGG [cytosol]

Physical Entity
Phospho AXN:Phospho APC:PP2A:CKIalpha:DCO:SGG [cytosol] (Drosophila melanogaster)
Activity
protein serine/threonine kinase activity (GO:0004674)
Authored
Williams, MG  (2006-12-07)
Reviewed
Kalderon, D  (2008-03-17)
Created
Williams, MG  (2006-12-08)
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