Phosphorylation of AXN and APC by DCO

Stable Identifier
R-DME-209143
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
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General
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Axin (AXN) and APC (APC/APC2) in the 'destruction complex' are primed for phosphorylation by the CKIepsilon orthologue DCO. Ser1505 in Human APC and Ser531 in Human Axin (equivalent to Ser621 in Mouse and Ser529 in Fly) are phosphorylated.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of AXN:APC:PP2A:CKIalpha:DCO:SGG [cytosol]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created