SPZ dimer bound TL dimerises at the plasma membrane

Stable Identifier
R-DME-209076
Type
Reaction [binding]
Species
Drosophila melanogaster
Compartment
ReviewStatus
5/5
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The binding of a Spatzle (SPZ) dimer to the N-terminus of the Toll (TL) receptor ectodomain triggers a conformational change in TL. This results in two discrete regions of the TL receptor ectodomains, one near the N-terminus and the other in the juxtamembrane region, to interact, inducing dimerisation and forming a 2:2 complex. The transmembrane segments of the receptor chains will be forced into close proximity forming additional favourable interactions which stabilise the dimer.
Literature References
PubMed ID Title Journal Year
12872120 Binding of the Drosophila cytokine Spatzle to Toll is direct and establishes signaling

Tauszig-Delamasure, S, Lelievre, E, Imler, JL, Gascan, H, Weber, AN, Morse, MA, Ray, KP, Gay, NJ, Hoffmann, JA

Nat Immunol 2003
15197269 Multimerization and interaction of Toll and Spatzle in Drosophila

Zhou, S, Tanji, T, Ip, YT, Yagi, Y, Hu, X

Proc Natl Acad Sci U S A 2004
15795223 Ligand-receptor and receptor-receptor interactions act in concert to activate signaling in the Drosophila toll pathway

Moncrieffe, MC, Imler, JL, Weber, AN, Gay, NJ, Gangloff, M

J Biol Chem 2005
18347020 Structural insight into the mechanism of activation of the Toll receptor by the dimeric ligand SpƤtzle

Sandercock, AM, Kao, C, Sarisky, R, Holzenburg, A, Weber, AN, Murali, A, Arnot, CJ, Robinson, CV, Xiong, J, Gay, NJ, Gangloff, M

J Biol Chem 2008
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