Phosphorylation of AXN and APC by SGG

Stable Identifier
R-DME-209049
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
Locations in the PathwayBrowser
General
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Additional phosphorylation of the scaffolding molecules, Axin (AXN) and APC (APC/APC2), is carried out by the GSK3beta kinase orthologue Shaggy (SGG) with Ser1501 (also a priming phosphorylation) in Human APC and Ser614 and Thr609 in Mouse Axin (equivalent to Ser522 and Thr517 respectively in Fly and Ser524 and Thr519 in Human).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of Phospho AXN:Phospho APC:PP2A:CKIalpha:DCO:SGG [cytosol]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created