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SPZ [extracellular region]
Stable Identifier
R-DME-205948
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
extracellular region
Locations in the PathwayBrowser
Expand all
Drosophila signaling pathways (Drosophila melanogaster)
Toll pathway (Drosophila melanogaster)
Degradation of NF-kappa-B inhibitor, CACT (Drosophila melanogaster)
Activated PLL kinase is autophosphorylated in the TL receptor 'signalling complex' (Drosophila melanogaster)
Activated PLL kinase is autophosphorylated in TL:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB:PLL [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL [plasma membrane] (Drosophila melanogaster)
SPZ dimer [extracellular region] (Drosophila melanogaster)
SPZ [extracellular region] (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB:Phospho PLL [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL [plasma membrane] (Drosophila melanogaster)
SPZ dimer [extracellular region] (Drosophila melanogaster)
SPZ [extracellular region] (Drosophila melanogaster)
Activated PLL kinase is autophosphorylated in TL:WEK:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:PLL:MYD88:TUB:WEK dimer:MYD88:TUB:PLL [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL [plasma membrane] (Drosophila melanogaster)
SPZ dimer [extracellular region] (Drosophila melanogaster)
SPZ [extracellular region] (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:PLL:MYD88:TUB:WEK dimer:MYD88:TUB:Phospho PLL [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL [plasma membrane] (Drosophila melanogaster)
SPZ dimer [extracellular region] (Drosophila melanogaster)
SPZ [extracellular region] (Drosophila melanogaster)
DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex' (Drosophila melanogaster)
DL dimer binds to TUB and phosphorylated PLL in TL:WEK:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:PLL:MYD88:TUB:WEK dimer:MYD88:TUB:Phospho PLL [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL [plasma membrane] (Drosophila melanogaster)
SPZ dimer [extracellular region] (Drosophila melanogaster)
SPZ [extracellular region] (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:PLL:MYD88:TUB:WEK dimer:MYD88:TUB:Phospho PLL:DL dimer:CACT [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL [plasma membrane] (Drosophila melanogaster)
SPZ dimer [extracellular region] (Drosophila melanogaster)
SPZ [extracellular region] (Drosophila melanogaster)
DL/DIF dimer binds to TUB and phosphorylated PLL in TL:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB:Phospho PLL [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL [plasma membrane] (Drosophila melanogaster)
SPZ dimer [extracellular region] (Drosophila melanogaster)
SPZ [extracellular region] (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB:Phospho PLL:DL/DIF dimer:CACT [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL [plasma membrane] (Drosophila melanogaster)
SPZ dimer [extracellular region] (Drosophila melanogaster)
SPZ [extracellular region] (Drosophila melanogaster)
DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex' (Drosophila melanogaster)
CACT and DL dimer are phosphorylated in TL:WEK:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:PLL:MYD88:TUB:WEK dimer:MYD88:TUB:Phospho PLL:DL dimer:CACT [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL [plasma membrane] (Drosophila melanogaster)
SPZ dimer [extracellular region] (Drosophila melanogaster)
SPZ [extracellular region] (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:PLL:MYD88:TUB:WEK dimer:MYD88:TUB:Phospho PLL:Phospho DL dimer:Phospho CACT [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL [plasma membrane] (Drosophila melanogaster)
SPZ dimer [extracellular region] (Drosophila melanogaster)
SPZ [extracellular region] (Drosophila melanogaster)
CACT and DL/DIF dimer are phosphorylated in TL:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB:Phospho PLL:DL/DIF dimer:CACT [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL [plasma membrane] (Drosophila melanogaster)
SPZ dimer [extracellular region] (Drosophila melanogaster)
SPZ [extracellular region] (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB:Phospho PLL:Phospho DL/DIF dimer:Phospho CACT [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL [plasma membrane] (Drosophila melanogaster)
SPZ dimer [extracellular region] (Drosophila melanogaster)
SPZ [extracellular region] (Drosophila melanogaster)
Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex' (Drosophila melanogaster)
Phosphorylated CACT and DL dimer dissociate from the TL:WEK:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:PLL:MYD88:TUB:WEK dimer:MYD88:TUB:Phospho PLL [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL [plasma membrane] (Drosophila melanogaster)
SPZ dimer [extracellular region] (Drosophila melanogaster)
SPZ [extracellular region] (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:PLL:MYD88:TUB:WEK dimer:MYD88:TUB:Phospho PLL:Phospho DL dimer:Phospho CACT [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL [plasma membrane] (Drosophila melanogaster)
SPZ dimer [extracellular region] (Drosophila melanogaster)
SPZ [extracellular region] (Drosophila melanogaster)
Phosphorylated CACT and DL/DIF dimer dissociate from the TL:MYD88:TUB:PLL 'signalling complex' (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB:Phospho PLL [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL [plasma membrane] (Drosophila melanogaster)
SPZ dimer [extracellular region] (Drosophila melanogaster)
SPZ [extracellular region] (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB:Phospho PLL:Phospho DL/DIF dimer:Phospho CACT [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL [plasma membrane] (Drosophila melanogaster)
SPZ dimer [extracellular region] (Drosophila melanogaster)
SPZ [extracellular region] (Drosophila melanogaster)
Formation of the trans-membrane 'signalling complex' (Drosophila melanogaster)
Adaptor protein complex binds to TL receptor at the plasma membrane (Drosophila melanogaster)
MYD88:TUB binds to TL receptor (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL [plasma membrane] (Drosophila melanogaster)
SPZ dimer [extracellular region] (Drosophila melanogaster)
SPZ [extracellular region] (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL [plasma membrane] (Drosophila melanogaster)
SPZ dimer [extracellular region] (Drosophila melanogaster)
SPZ [extracellular region] (Drosophila melanogaster)
WEK and MYD88:TUB bind to the TL receptor (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL [plasma membrane] (Drosophila melanogaster)
SPZ dimer [extracellular region] (Drosophila melanogaster)
SPZ [extracellular region] (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB:WEK dimer:MYD88:TUB [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL [plasma membrane] (Drosophila melanogaster)
SPZ dimer [extracellular region] (Drosophila melanogaster)
SPZ [extracellular region] (Drosophila melanogaster)
Full-length SPZ dimer is cleaved by EA/SPE serine protease (Drosophila melanogaster)
ProSPZ:SPZ dimer [extracellular region] (Drosophila melanogaster)
SPZ dimer [extracellular region] (Drosophila melanogaster)
SPZ [extracellular region] (Drosophila melanogaster)
PLL kinase binds to TUB in the TL receptor 'signalling complex' (Drosophila melanogaster)
PLL kinase binds to TL:MYD88:TUB 'signalling complex' (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL [plasma membrane] (Drosophila melanogaster)
SPZ dimer [extracellular region] (Drosophila melanogaster)
SPZ [extracellular region] (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB:PLL [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL [plasma membrane] (Drosophila melanogaster)
SPZ dimer [extracellular region] (Drosophila melanogaster)
SPZ [extracellular region] (Drosophila melanogaster)
PLL kinase binds to TL:WEK:MYD88:TUB 'signalling complex' (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:MYD88:TUB:WEK dimer:MYD88:TUB [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL [plasma membrane] (Drosophila melanogaster)
SPZ dimer [extracellular region] (Drosophila melanogaster)
SPZ [extracellular region] (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer:PLL:MYD88:TUB:WEK dimer:MYD88:TUB:PLL [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL [plasma membrane] (Drosophila melanogaster)
SPZ dimer [extracellular region] (Drosophila melanogaster)
SPZ [extracellular region] (Drosophila melanogaster)
ProSPZ:SPZ dimer binds to TL receptor at the plasma membrane (Drosophila melanogaster)
ProSPZ:SPZ dimer [extracellular region] (Drosophila melanogaster)
SPZ dimer [extracellular region] (Drosophila melanogaster)
SPZ [extracellular region] (Drosophila melanogaster)
SPZ dimer:TL [plasma membrane] (Drosophila melanogaster)
SPZ dimer [extracellular region] (Drosophila melanogaster)
SPZ [extracellular region] (Drosophila melanogaster)
SPZ dimer bound TL dimerises at the plasma membrane (Drosophila melanogaster)
SPZ dimer:TL [plasma membrane] (Drosophila melanogaster)
SPZ dimer [extracellular region] (Drosophila melanogaster)
SPZ [extracellular region] (Drosophila melanogaster)
SPZ dimer:TL dimer:SPZ dimer [plasma membrane] (Drosophila melanogaster)
SPZ dimer:TL [plasma membrane] (Drosophila melanogaster)
SPZ dimer [extracellular region] (Drosophila melanogaster)
SPZ [extracellular region] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:P48607 spz
Gene Names
spz, CG6134
Chain
signal peptide:1-25, chain:26-326, chain:221-326
Reference Genes
BioGPS Gene:43256 spz
CTD Gene:43256 spz
KEGG Gene (Drosophila melanogaster):Dmel_CG6134 spz
Monarch:43256 spz
NCBI Gene:43256 spz
UCSC:P48607 spz
Reference Transcript
RefSeq:NM_170315.2 spz
RefSeq:NM_170309.2 spz
RefSeq:NM_170316.2 spz
RefSeq:NM_170312.2 spz
RefSeq:NM_079802.3 spz
Other Identifiers
141691_at
1641068_a_at
43256
GO:0002225
GO:0002347
GO:0002376
GO:0002804
GO:0002807
GO:0005121
GO:0005125
GO:0005576
GO:0005615
GO:0006965
GO:0006967
GO:0007310
GO:0007526
GO:0008045
GO:0008063
GO:0008083
GO:0008592
GO:0009611
GO:0009950
GO:0009953
GO:0010628
GO:0012501
GO:0021556
GO:0022414
GO:0023052
GO:0030154
GO:0031640
GO:0035212
GO:0042542
GO:0042803
GO:0043524
GO:0045087
GO:0048018
GO:0048856
GO:0050829
GO:0050830
GO:0050832
GO:0061760
GO:0098542
GO:0098772
Participates
as a component of
SPZ dimer [extracellular region] (Drosophila melanogaster)
Other forms of this molecule
ProSPZ [extracellular region]
SPZ full-length [extracellular region]
Cross References
RefSeq
NP_733195.1
,
NP_733188.1
,
NP_733194.1
,
NP_524526.1
,
NP_733191.1
Flybase
FBgn0003495
PRO
P48607
PDB
3E07
,
4BV4
,
4LXR
,
4LXS
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P08953 Tl
6
TL [plasma membrane]
(R-DME-206218)
Tl [secretory granule membrane]
(R-DME-6804777)
Tl [plasma membrane]
(R-DME-167926)
Tl [plasma membrane]
(R-DME-166045)
Tl [plasma membrane]
(R-DME-168061)
Tl [plasma membrane]
(R-DME-167992)
0.534
2
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