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FZ [plasma membrane]
Stable Identifier
R-DME-205850
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Drosophila signaling pathways (Drosophila melanogaster)
Planar Cell Polarity pathway (Drosophila melanogaster)
Activation of Downstream Effectors (Drosophila melanogaster)
Activation of RAC1:GTP by FZ:DSH complex (Drosophila melanogaster)
DSH binds to RAC1:GTP (Drosophila melanogaster)
PK:VANG:STAN dimer:FZ:DSH:DGO [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
PK:VANG:STAN dimer:FZ:DSH:DGO:RAC1:GTP [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
RAC1:GTP and MSN activate HEP (Drosophila melanogaster)
PK:VANG:STAN dimer:FZ:DSH:DGO:RAC1:GTP [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
RHO1 signalling (Drosophila melanogaster)
Activation of RHO1 by FZ:DSH complex (Drosophila melanogaster)
DSH binds to DAAM (Drosophila melanogaster)
PK:VANG:STAN dimer:FZ:DSH:DGO [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
PK:VANG:STAN dimer:FZ:DSH:DGO:DAAM [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
RHO1:GTP binds to activated DAAM (Drosophila melanogaster)
PK:VANG:STAN dimer:FZ:DSH:DGO:DAAM [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
PK:VANG:STAN dimer:FZ:DSH:DGO:DAAM:RHO1:GTP [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
ROK binds to activated RHO1:GTP (Drosophila melanogaster)
PK:VANG:STAN dimer:FZ:DSH:DGO:DAAM:RHO1:GTP [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
PK:VANG:STAN dimer:FZ:DSH:DGO:DAAM:RHO1:GTP:ROK [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
Activation of non-muscle Myosin II (Drosophila melanogaster)
ROK phosphorylates MBS (Drosophila melanogaster)
PK:VANG:STAN dimer:FZ:DSH:DGO:DAAM:RHO1:GTP:ROK [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
ROK phosphorylates SQH (Drosophila melanogaster)
PK:VANG:STAN dimer:FZ:DSH:DGO:DAAM:RHO1:GTP:ROK [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
Inhibition of actin polymerisation (Drosophila melanogaster)
VANG, IN, FY, and FRTZ colocalise at the plasma membrane (Drosophila melanogaster)
PK:VANG:STAN dimer:FZ:DSH:DGO [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
Formation and asymmetric localisation of transmembrane complexes (Drosophila melanogaster)
DGO binds to DSH (Drosophila melanogaster)
PK:VANG:STAN dimer:FZ:DSH [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
PK:VANG:STAN dimer:FZ:DSH:DGO [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
DSH binds to FZ at the plasma membrane (Drosophila melanogaster)
VANG:STAN dimer:FZ [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
VANG:STAN dimer:FZ:DSH [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
PK binds to VANG at the plasma membrane (Drosophila melanogaster)
PK:VANG:STAN dimer:FZ:DSH [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
VANG:STAN dimer:FZ:DSH [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
Homo-/heterophilic binding of transmembrane components (Drosophila melanogaster)
FZ and VANG bind to STAN homodimer (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
VANG:STAN dimer:FZ [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
Wingless pathway (Drosophila melanogaster)
WG ligand bound to FZ receptors (Drosophila melanogaster)
Assembly of receptor complex (Drosophila melanogaster)
Membrane-bound GISH binds to ARR receptor complex (Drosophila melanogaster)
WG:FZ:ARR [plasma membrane] (Drosophila melanogaster)
WG:FZ [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
WG:FZ:ARR:GISH [plasma membrane] (Drosophila melanogaster)
WG:FZ:ARR [plasma membrane] (Drosophila melanogaster)
WG:FZ [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
Phosphorylation of ARR (Drosophila melanogaster)
GISH further phosphorylates ARR in the receptor complex (Drosophila melanogaster)
WG:FZ:Phospho (3 sites) ARR:GISH [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
WG:FZ:Phospho ARR:GISH [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
Membrane localised SGG phosphorylates ARR (Drosophila melanogaster)
WG:FZ:ARR:GISH [plasma membrane] (Drosophila melanogaster)
WG:FZ:ARR [plasma membrane] (Drosophila melanogaster)
WG:FZ [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
WG:FZ:Phospho ARR:GISH [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
WG, FZ and ARR bind to each other (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
WG:FZ:ARR [plasma membrane] (Drosophila melanogaster)
WG:FZ [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM (Drosophila melanogaster)
Destabilisation and degradation of AXN in the 'destruction complex' (Drosophila melanogaster)
WG:FZ:Phospho (3 sites) ARR:GISH:DSH:APC:PP2A:CKIalpha:DCO:SGG [plasma membrane] (Drosophila melanogaster)
WG:FZ:Phospho (3 sites) ARR:GISH [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
WG:FZ:Phospho (3 sites) ARR:GISH:DSH:AXN:APC:PP2A:CKIalpha:DCO:SGG [plasma membrane] (Drosophila melanogaster)
WG:FZ:Phospho (3 sites) ARR:GISH [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
Disassembly of the destabilised 'destruction complex' (Drosophila melanogaster)
WG:FZ:Phospho (3 sites) ARR:GISH [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
WG:FZ:Phospho (3 sites) ARR:GISH:DSH:APC:PP2A:CKIalpha:DCO:SGG [plasma membrane] (Drosophila melanogaster)
WG:FZ:Phospho (3 sites) ARR:GISH [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
Inhibition of SGG results in the dephosphorylation of the 'destruction complex' by PP2A and release of ARM (Drosophila melanogaster)
WG:FZ:Phospho (3 sites) ARR:GISH:DSH:AXN:APC:PP2A:CKIalpha:DCO:SGG [plasma membrane] (Drosophila melanogaster)
WG:FZ:Phospho (3 sites) ARR:GISH [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
WG:FZ:Phospho (3 sites) ARR:GISH:Phospho ARM (4 sites):DSH:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [plasma membrane] (Drosophila melanogaster)
WG:FZ:Phospho (3 sites) ARR:GISH [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
Membrane recruitment of DSH to FZ and AXN to phosphorylated ARR (Drosophila melanogaster)
WG:FZ:Phospho (3 sites) ARR:GISH [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
WG:FZ:Phospho (3 sites) ARR:GISH:Phospho ARM (4 sites):DSH:Phospho (3 sites) AXN:Phospho (6 sites) APC:PP2A:CKIalpha:DCO:SGG [plasma membrane] (Drosophila melanogaster)
WG:FZ:Phospho (3 sites) ARR:GISH [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
FZ [plasma membrane] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:P18537 fz
Gene Names
fz, CG17697
Chain
signal peptide:1-18, chain:19-581
Reference Genes
BioGPS Gene:45307 fz
KEGG Gene (Drosophila melanogaster):Dmel_CG17697 fz
Monarch:45307 fz
NCBI Gene:45307 fz
Reference Transcript
RefSeq:NM_080073.3 fz
Other Identifiers
143173_at
154598_at
1631231_at
7227.FBpp0303135
AAF49746.3
AY051808
CAA38460.1
CAA38461.1
EntrezGene:45307
FBgn0001085
FBpp0075485
FBtr0075743
GO:0000003
GO:0000902
GO:0001736
GO:0001737
GO:0001738
GO:0001745
GO:0002376
GO:0003674
GO:0004888
GO:0004930
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005737
GO:0005768
GO:0005886
GO:0005887
GO:0007010
GO:0007155
GO:0007156
GO:0007163
GO:0007164
GO:0007165
GO:0007166
GO:0007186
GO:0007267
GO:0007275
GO:0007298
GO:0007367
GO:0007435
GO:0007464
GO:0007507
GO:0008150
GO:0008283
GO:0008356
GO:0009790
GO:0016020
GO:0016021
GO:0016055
GO:0016318
GO:0016360
GO:0017147
GO:0022607
GO:0030010
GO:0030154
GO:0031410
GO:0032231
GO:0035159
GO:0035206
GO:0035293
GO:0035317
GO:0035320
GO:0035567
GO:0040007
GO:0040011
GO:0042067
GO:0042813
GO:0043226
GO:0045198
GO:0045746
GO:0045773
GO:0048646
GO:0048675
GO:0048856
GO:0048870
GO:0051301
GO:0060070
GO:0060071
GO:1902669
IPR000539
IPR015526
IPR017981
IPR020067
IPR036790
NM_080073.3
NP_524812.1
NR_124938.1
PF01392
PF01534
PR00489
SM00063
SM01330
UPI00001246EB
X54646
X54647
Participant Of
hasComponent
PK:VANG:STAN dimer:FZ:DSH [plasma membrane]
PK:VANG:STAN dimer:FZ:DSH:DGO [plasma membrane]
PK:VANG:STAN dimer:FZ:DSH:DGO:DAAM [plasma membrane]
PK:VANG:STAN dimer:FZ:DSH:DGO:DAAM:RHO1:GTP [plasma membrane]
PK:VANG:STAN dimer:FZ:DSH:DGO:DAAM:RHO1:GTP:ROK [plasma membrane]
PK:VANG:STAN dimer:FZ:DSH:DGO:RAC1:GTP [plasma membrane]
VANG:STAN dimer:FZ [plasma membrane]
VANG:STAN dimer:FZ:DSH [plasma membrane]
hasMember
FZ [plasma membrane]
input
FZ and VANG bind to STAN homodimer
Other forms of this molecule
FZD2 [clathrin-coated endocytic vesicle membrane]
FZD7 [plasma membrane]
FZD1 [plasma membrane]
FZD2 [plasma membrane]
FZD3 [plasma membrane]
FZD6 [plasma membrane]
Cross References
RefSeq
NP_524812.1
Flybase
FBgn0001085
PRO
P18537
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9V5N8 stan
1
STAN [plasma membrane]
(R-DME-350928)
0.524
3
UniProt:P51140 dsh
14
ub-DVL3 [cytosol]
(R-DME-4652688)
ub-DVL2 [cytosol]
(R-DME-4652689)
ub-DVL1 [cytosol]
(R-DME-4641157)
DSH [cytosol]
(R-DME-205749)
DVL3 [cytosol]
(R-DME-201678)
DVL1 [cytosol]
(R-DME-201687)
DVL2 [cytosol]
(R-DME-201694)
phospho-p-DVL2 [clathrin-coated endocytic vesicle]
(R-DME-5138444)
phospho-p-DVL2 [cytosol]
(R-DME-201706)
phospho-p-S-DVL1 [cytosol]
(R-DME-201700)
phospho-p-DVL3 [cytosol]
(R-DME-201680)
phospho-pp-DVL2 [cytosol]
(R-DME-3772398)
phospho-pp-DVL3 [cytosol]
(R-DME-3772400)
phospho-pp-DVL1 [cytosol]
(R-DME-3772396)
0.502
2
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