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phospho-2xPalmC-MyrG-p-S1177-NOS3 [plasma membrane]
Stable Identifier
R-DME-202139
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
plasma membrane
Synonyms
Q27571
Locations in the PathwayBrowser
Expand all
Metabolism (Drosophila melanogaster)
Metabolism of nitric oxide: NOS3 activation and regulation (Drosophila melanogaster)
eNOS activation (Drosophila melanogaster)
AKT1 phosphorylates eNOS (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
phospho-2xPalmC-MyrG-p-S1177-NOS3 [plasma membrane] (Drosophila melanogaster)
BH2 binding can lead to eNOS uncoupling (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
phospho-2xPalmC-MyrG-p-S1177-NOS3 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
phospho-2xPalmC-MyrG-p-S1177-NOS3 [plasma membrane] (Drosophila melanogaster)
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
phospho-2xPalmC-MyrG-p-S1177-NOS3 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
phospho-2xPalmC-MyrG-p-S1177-NOS3 [plasma membrane] (Drosophila melanogaster)
Uncoupled eNOS favours the formation of superoxide (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
phospho-2xPalmC-MyrG-p-S1177-NOS3 [plasma membrane] (Drosophila melanogaster)
eNOS synthesizes NO (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
phospho-2xPalmC-MyrG-p-S1177-NOS3 [plasma membrane] (Drosophila melanogaster)
Metabolism of vitamins and cofactors (Drosophila melanogaster)
Metabolism of cofactors (Drosophila melanogaster)
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation (Drosophila melanogaster)
BH2 binding can lead to eNOS uncoupling (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
phospho-2xPalmC-MyrG-p-S1177-NOS3 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
phospho-2xPalmC-MyrG-p-S1177-NOS3 [plasma membrane] (Drosophila melanogaster)
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
phospho-2xPalmC-MyrG-p-S1177-NOS3 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
phospho-2xPalmC-MyrG-p-S1177-NOS3 [plasma membrane] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
Signaling by Nuclear Receptors (Drosophila melanogaster)
ESR-mediated signaling (Drosophila melanogaster)
Extra-nuclear estrogen signaling (Drosophila melanogaster)
eNOS synthesizes NO (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
phospho-2xPalmC-MyrG-p-S1177-NOS3 [plasma membrane] (Drosophila melanogaster)
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by VEGF (Drosophila melanogaster)
VEGFA-VEGFR2 Pathway (Drosophila melanogaster)
VEGFR2 mediated vascular permeability (Drosophila melanogaster)
AKT1 phosphorylates eNOS (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
phospho-2xPalmC-MyrG-p-S1177-NOS3 [plasma membrane] (Drosophila melanogaster)
The cofactor BH4 is required for electron transfer in the eNOS catalytic cycle (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
phospho-2xPalmC-MyrG-p-S1177-NOS3 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
phospho-2xPalmC-MyrG-p-S1177-NOS3 [plasma membrane] (Drosophila melanogaster)
eNOS synthesizes NO (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] (Drosophila melanogaster)
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
phospho-2xPalmC-MyrG-p-S1177-NOS3 [plasma membrane] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q27571
Reference Genes
BioGPS Gene:34495
CTD Gene:34495
ENSEMBL:FBgn0011676
Flybase:FBgn0011676
KEGG Gene (Drosophila melanogaster):Dmel_CG6713
Monarch:34495
NCBI Gene:34495
Reference Transcript
RefSeq:NM_001032069.2
RefSeq:NM_001032072.2
RefSeq:NM_078817.4
Other Identifiers
143676_at
1625574_at
34495
GO:0002027
GO:0003013
GO:0003824
GO:0004517
GO:0005516
GO:0005575
GO:0005634
GO:0005777
GO:0005829
GO:0005886
GO:0006260
GO:0006520
GO:0006527
GO:0006809
GO:0007263
GO:0007399
GO:0007416
GO:0007444
GO:0008156
GO:0008285
GO:0009725
GO:0010181
GO:0012506
GO:0016491
GO:0020037
GO:0023052
GO:0031284
GO:0032496
GO:0034330
GO:0043226
GO:0046620
GO:0046872
GO:0048856
GO:0050660
GO:0050661
GO:0055086
GO:0140460
Participates
as a component of
p-S1177-eNOS dimer [plasma membrane] (Drosophila melanogaster)
Other forms of this molecule
NOS2 [peroxisomal matrix]
NOS1 [cytosol]
NOS2 [cytosol]
NOS3 [cytosol]
2xPalmC-MyrG-NOS3 [Golgi membrane]
MyrG-NOS3 [Golgi membrane]
MyrG-NOS3 [cytosol]
2xPalmC-MyrG-NOS3 [plasma membrane]
Inferred From
2xPalmC-MyrG-p-S1177-NOS3 [plasma membrane]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 1177 (in Homo sapiens)
Coordinate
1177
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
S-palmitoyl-L-cysteine at 15 (in Homo sapiens)
Coordinate
15
PsiMod Name
S-palmitoyl-L-cysteine [MOD:00115]
PsiMod Definition
A protein modification that effectively converts an L-cysteine residue to S-palmitoyl-L-cysteine.
Name
S-palmitoyl-L-cysteine at 26 (in Homo sapiens)
Coordinate
26
PsiMod Name
S-palmitoyl-L-cysteine [MOD:00115]
PsiMod Definition
A protein modification that effectively converts an L-cysteine residue to S-palmitoyl-L-cysteine.
Name
N-myristoylglycine at 2 (in Homo sapiens)
Coordinate
2
PsiMod Name
N-myristoylglycine [MOD:00068]
PsiMod Definition
A protein modification that effectively converts a glycine residue to N-myristoylglycine.
Cross References
RefSeq
NP_001027243.2
,
NP_001027240.1
,
NP_523541.2
Flybase
FBgn0011676
IntEnz
1.14.13.39
PRO
Q27571
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