Reactome | Fem-1 [cytosol]

Fem-1 [cytosol]

Stable Identifier

R-DME-201572

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

cytosol

Synonyms

FEM1B, A1ZBY1

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Drosophila melanogaster)

- Post-translational protein modification (Drosophila melanogaster)
  - Neddylation (Drosophila melanogaster)
    - AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Drosophila melanogaster)
      - NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
        
        CUL2-box protein [cytosol] (Drosophila melanogaster)
        
        Fem-1 [cytosol] (Drosophila melanogaster)
      - NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
        
        NEDD8-CRL2 E3 ligase complex [cytosol] (Drosophila melanogaster)
        
        CUL2-box protein [cytosol] (Drosophila melanogaster)
        
        Fem-1 [cytosol] (Drosophila melanogaster)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Drosophila melanogaster)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Drosophila melanogaster)
        
        CRL E3 ubiquitin ligases [cytosol] (Drosophila melanogaster)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
        
        CUL2-box protein [cytosol] (Drosophila melanogaster)
        
        Fem-1 [cytosol] (Drosophila melanogaster)
      - CRL E3 ubiquitin ligases [cytosol] (Drosophila melanogaster)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
        
        CUL2-box protein [cytosol] (Drosophila melanogaster)
        
        Fem-1 [cytosol] (Drosophila melanogaster)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Drosophila melanogaster)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Drosophila melanogaster)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
        
        CUL2-box protein [cytosol] (Drosophila melanogaster)
        
        Fem-1 [cytosol] (Drosophila melanogaster)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Drosophila melanogaster)
        
        NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
        
        NEDD8-CRL2 E3 ligase complex [cytosol] (Drosophila melanogaster)
        
        CUL2-box protein [cytosol] (Drosophila melanogaster)
        
        Fem-1 [cytosol] (Drosophila melanogaster)
    - NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Drosophila melanogaster)
      - CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
        
        CUL2-box protein [cytosol] (Drosophila melanogaster)
        
        Fem-1 [cytosol] (Drosophila melanogaster)
      - NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Drosophila melanogaster)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Drosophila melanogaster)
        
        CRL2 E3 ubiquitin ligase [cytosol] (Drosophila melanogaster)
        
        CUL2-box protein [cytosol] (Drosophila melanogaster)
        
        Fem-1 [cytosol] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:A1ZBY1

Gene Names

Fem-1

Reference Genes

BioGPS Gene:37344 Fem-1

CTD Gene:37344 Fem-1

ENSEMBL:FBgn0034542

Flybase:FBgn0034542

KEGG Gene (Drosophila melanogaster):Dmel_CG9025 Fem-1

Monarch:37344 Fem-1

NCBI Gene:37344 Fem-1

UCSC:A1ZBY1 Fem-1

Reference Transcript

Other Identifiers

147568_at

1638186_a_at

37344

GO:0005515

GO:0005575

GO:0016567

GO:0036211

GO:0051438

Participates

as a member of

CUL2-box protein [cytosol] (Drosophila melanogaster)

Inferred From

FEM1B [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_611508.1, NP_725993.1

Flybase

FBgn0034542

PRO

A1ZBY1