Endoplasmic reticulum calcium ATPases positively regulate Notch precursor trafficking

Stable Identifier
R-DME-1984022
Type
Reaction [omitted]
Species
Drosophila melanogaster
Compartment
General
SVG |   | PPTX  | SBGN
Endoplasmic reticulum calcium ATPases positively regulate Notch precursor trafficking

In Drosophila, mutations that lead to the loss of function of endoplasmic reticulum membrane calcium ATPase Ca-P60A result in impaired Notch cleavage by furin (although furin is not directly affected) and Notch trafficking to the cell surface. This could be due to Notch misfolding in the endoplasmic reticulum at suboptimal concentrations of calcium.

Literature References
PubMed ID Title Journal Year
10545110 Ca(2+)-ATPase function is required for intracellular trafficking of the Notch receptor in Drosophila

Periz, G, Fortini, ME

EMBO J 1999
Participants
This event is regulated
Orthologous Events
Authored
Reviewed
Created