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NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane]
Stable Identifier
R-DME-1963583
Type
Complex
Species
Drosophila melanogaster
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Signal Transduction (Drosophila melanogaster)
Intracellular signaling by second messengers (Drosophila melanogaster)
PIP3 activates AKT signaling (Drosophila melanogaster)
Negative regulation of the PI3K/AKT network (Drosophila melanogaster)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Drosophila melanogaster)
PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
Activator:PI3K [plasma membrane] (Drosophila melanogaster)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Drosophila melanogaster)
NRG1/2:p-ERBB3:p-ERBB2:PIK3R1 [plasma membrane] (Drosophila melanogaster)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Drosophila melanogaster)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Drosophila melanogaster)
PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
Activator:PI3K [plasma membrane] (Drosophila melanogaster)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Drosophila melanogaster)
NRG1/2:p-ERBB3:p-ERBB2:PIK3R1 [plasma membrane] (Drosophila melanogaster)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Drosophila melanogaster)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Drosophila melanogaster)
MAPK family signaling cascades (Drosophila melanogaster)
MAPK1/MAPK3 signaling (Drosophila melanogaster)
RAF/MAP kinase cascade (Drosophila melanogaster)
RAS GEFs promote RAS nucleotide exchange (Drosophila melanogaster)
RAS GEFs [plasma membrane] (Drosophila melanogaster)
GRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Drosophila melanogaster)
p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Drosophila melanogaster)
p-ERBB2 heterodimers [plasma membrane] (Drosophila melanogaster)
p-6Y-ERBB2 heterodimers [plasma membrane] (Drosophila melanogaster)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Drosophila melanogaster)
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by ERBB2 (Drosophila melanogaster)
Downregulation of ERBB2 signaling (Drosophila melanogaster)
Downregulation of ERBB2:ERBB3 signaling (Drosophila melanogaster)
RNF41 binds neuregulin-activated ERBB3 (Drosophila melanogaster)
NRG1/2:p-10Y-ERBB3:p-ERBB2:RNF41 [plasma membrane] (Drosophila melanogaster)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Drosophila melanogaster)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Drosophila melanogaster)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Drosophila melanogaster)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Drosophila melanogaster)
RNF41 ubiquitinates activated ERBB3 (Drosophila melanogaster)
NRG1/2:Ub-p-10Y-ERBB3:p-ERBB2 [plasma membrane] (Drosophila melanogaster)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Drosophila melanogaster)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Drosophila melanogaster)
NRG1/2:p-10Y-ERBB3:p-ERBB2:RNF41 [plasma membrane] (Drosophila melanogaster)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Drosophila melanogaster)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Drosophila melanogaster)
MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Drosophila melanogaster)
p-ERBB2 heterodimers [plasma membrane] (Drosophila melanogaster)
p-6Y-ERBB2 heterodimers [plasma membrane] (Drosophila melanogaster)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Drosophila melanogaster)
p-ERBB2 heterodimers:MATK [plasma membrane] (Drosophila melanogaster)
p-ERBB2 heterodimers [plasma membrane] (Drosophila melanogaster)
p-6Y-ERBB2 heterodimers [plasma membrane] (Drosophila melanogaster)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Drosophila melanogaster)
ERBB2 Regulates Cell Motility (Drosophila melanogaster)
MEMO1 binds RHOA:GTP:DIAPH1 (Drosophila melanogaster)
p-ERBB2 heterodimers:MEMO1 [plasma membrane] (Drosophila melanogaster)
p-ERBB2 heterodimers [plasma membrane] (Drosophila melanogaster)
p-6Y-ERBB2 heterodimers [plasma membrane] (Drosophila melanogaster)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Drosophila melanogaster)
p-ERBB2 heterodimers:MEMO1:RHOA:GTP:DIAPH1 [plasma membrane] (Drosophila melanogaster)
p-ERBB2 heterodimers:MEMO1 [plasma membrane] (Drosophila melanogaster)
p-ERBB2 heterodimers [plasma membrane] (Drosophila melanogaster)
p-6Y-ERBB2 heterodimers [plasma membrane] (Drosophila melanogaster)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Drosophila melanogaster)
Phosphorylated ERBB2 heterodimers bind MEMO1 (Drosophila melanogaster)
p-ERBB2 heterodimers [plasma membrane] (Drosophila melanogaster)
p-6Y-ERBB2 heterodimers [plasma membrane] (Drosophila melanogaster)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Drosophila melanogaster)
p-ERBB2 heterodimers:MEMO1 [plasma membrane] (Drosophila melanogaster)
p-ERBB2 heterodimers [plasma membrane] (Drosophila melanogaster)
p-6Y-ERBB2 heterodimers [plasma membrane] (Drosophila melanogaster)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Drosophila melanogaster)
PI3K events in ERBB2 signaling (Drosophila melanogaster)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Drosophila melanogaster)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Drosophila melanogaster)
NRG1/2:p-ERBB3:p-ERBB2:PIK3R1 [plasma membrane] (Drosophila melanogaster)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Drosophila melanogaster)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Drosophila melanogaster)
SHC1 events in ERBB2 signaling (Drosophila melanogaster)
SHC1 phosphorylation by ERBB2 heterodimers (Drosophila melanogaster)
SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Drosophila melanogaster)
p-ERBB2 heterodimers [plasma membrane] (Drosophila melanogaster)
p-6Y-ERBB2 heterodimers [plasma membrane] (Drosophila melanogaster)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Drosophila melanogaster)
p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Drosophila melanogaster)
p-ERBB2 heterodimers [plasma membrane] (Drosophila melanogaster)
p-6Y-ERBB2 heterodimers [plasma membrane] (Drosophila melanogaster)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Drosophila melanogaster)
Trans-autophosphorylation of ERBB2 heterodimers (Drosophila melanogaster)
p-6Y-ERBB2 heterodimers [plasma membrane] (Drosophila melanogaster)
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane] (Drosophila melanogaster)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
NRG1/2:p-10Y-ERBB3 [plasma membrane]
(Drosophila melanogaster)
phospho-p-Y-ERBB2 [plasma membrane]
(Drosophila melanogaster)
Participates
as a member of
Phosphorylated p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 heterodimers [plasma membrane] (Drosophila melanogaster)
p-6Y-ERBB2 heterodimers [plasma membrane] (Drosophila melanogaster)
Phosphorylated ERBB2:ERBB3 heterodimers [plasma membrane] (Drosophila melanogaster)
Inferred From
NRG1/2:p-10Y-ERBB3:p-Y-ERBB2 [plasma membrane]
(Homo sapiens)
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