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What is Reactome ?
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Klotho bound to FGF23 [plasma membrane]
Stable Identifier
R-DME-190208
Type
Complex
Species
Drosophila melanogaster
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Signal Transduction (Drosophila melanogaster)
Intracellular signaling by second messengers (Drosophila melanogaster)
PIP3 activates AKT signaling (Drosophila melanogaster)
Negative regulation of the PI3K/AKT network (Drosophila melanogaster)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Drosophila melanogaster)
PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
Activator:PI3K [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS2 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS2 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
Activator:PI3K [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS2 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS2 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
MAPK family signaling cascades (Drosophila melanogaster)
MAPK1/MAPK3 signaling (Drosophila melanogaster)
RAF/MAP kinase cascade (Drosophila melanogaster)
RAS GEFs promote RAS nucleotide exchange (Drosophila melanogaster)
RAS GEFs [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS2 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS3 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-SHC1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by FGFR (Drosophila melanogaster)
Signaling by FGFR1 (Drosophila melanogaster)
Downstream signaling of activated FGFR1 (Drosophila melanogaster)
Activated FGFR1 binds FLRT1,2,3 (Drosophila melanogaster)
Activated FGFR1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:FLRT [plasma membrane] (Drosophila melanogaster)
Activated FGFR1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
FRS-mediated FGFR1 signaling (Drosophila melanogaster)
Activated FGFR1 binds FRS2 (Drosophila melanogaster)
Activated FGFR1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:FRS2 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1 binds FRS3 (Drosophila melanogaster)
Activated FGFR1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:FRS3 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1 phosphorylates FRS2 (Drosophila melanogaster)
Activated FGFR1:FRS2 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS2 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1 phosphorylates FRS3 (Drosophila melanogaster)
Activated FGFR1:FRS3 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS3 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS binds GRB2:SOS1 (Drosophila melanogaster)
Activated FGFR1:p-FRS [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS2 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS3 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS2 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS3 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS phosphorylates PPTN11 (Drosophila melanogaster)
Activated FGFR1:p-FRS:PTPN11 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS2 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS3 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS:p-PTPN11 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS2 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS3 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)
Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS2 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS3 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange (Drosophila melanogaster)
Activated FGFR1:p-FRS:p-PTPN11 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS2 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS3 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
PI-3K cascade:FGFR1 (Drosophila melanogaster)
Activated FGFR1:p-FRS2 binds GRB2:GAB1:PIK3R1 (Drosophila melanogaster)
Activated FGFR1:p-FRS2 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS2 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1 (Drosophila melanogaster)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS2 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS2 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
Activated FGFR:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS2 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Drosophila melanogaster)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS2:GRB2:GAB1:PIK3R1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS2 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
Phospholipase C-mediated cascade: FGFR1 (Drosophila melanogaster)
Activated FGFR1 binds PLCG1 (Drosophila melanogaster)
Activated FGFR1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
activated FGFR1:PLCG1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1 phosphorylates PLCG1 (Drosophila melanogaster)
activated FGFR1:PLCG1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
activated FGFR1:p-4Y-PLCG1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
p-4Y-PLCG1 dissociates from activated FGFR1 (Drosophila melanogaster)
Activated FGFR1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
activated FGFR1:p-4Y-PLCG1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
SHC-mediated cascade:FGFR1 (Drosophila melanogaster)
Activated FGFR1 binds SHC1 (Drosophila melanogaster)
Activated FGFR1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:SHC1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1 phosphorylates SHC1 (Drosophila melanogaster)
Activated FGFR1:SHC1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-SHC1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Drosophila melanogaster)
Activated FGFR1:p-SHC1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-SHC1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Drosophila melanogaster)
Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-SHC1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
FGFR1 ligand binding and activation (Drosophila melanogaster)
FGFR1c and Klotho ligand binding and activation (Drosophila melanogaster)
Autocatalytic phosphorylation of Klotho-bound FGFR1c (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
FGF23 bound to Klotho and FGFR1c [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
FGFR1c binds to Klotho-bound FGF23 (Drosophila melanogaster)
FGF23 bound to Klotho and FGFR1c [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
Negative regulation of FGFR1 signaling (Drosophila melanogaster)
Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2. (Drosophila melanogaster)
Activated FGFR1:FRS2 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-8T-FRS2 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
CBL ubiquitinates FRS2 and FGFR1 (Drosophila melanogaster)
Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS2 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
Ub-Activated FGFR1 complex:Ub-p-FRS2 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS2 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
p-CBL:GRB2 binds p-FRS2:activated FGFR1 (Drosophila melanogaster)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS2 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS2:p-PTPN11:p-CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS2:p-PTPN11 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1:p-FRS2 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1 [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
Signaling by Insulin receptor (Drosophila melanogaster)
Insulin receptor signalling cascade (Drosophila melanogaster)
IRS-mediated signalling (Drosophila melanogaster)
PI3K Cascade (Drosophila melanogaster)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Drosophila melanogaster)
PI3K-containing complexes [cytosol] (Drosophila melanogaster)
Activated FGFR bound to PI3K [cytosol] (Drosophila melanogaster)
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Drosophila melanogaster)
Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] (Drosophila melanogaster)
Activated FGFR:p-FRS2 [plasma membrane] (Drosophila melanogaster)
Activated FGFR [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Drosophila melanogaster)
IGF1R signaling cascade (Drosophila melanogaster)
IRS-related events triggered by IGF1R (Drosophila melanogaster)
IRS-mediated signalling (Drosophila melanogaster)
PI3K Cascade (Drosophila melanogaster)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Drosophila melanogaster)
PI3K-containing complexes [cytosol] (Drosophila melanogaster)
Activated FGFR bound to PI3K [cytosol] (Drosophila melanogaster)
GRB2 and GAB1 bound to activated FGFR and FRS2-alpha [plasma membrane] (Drosophila melanogaster)
Activated FGFR:p-FRS2:p-PTPN11 [plasma membrane] (Drosophila melanogaster)
Activated FGFR:p-FRS2 [plasma membrane] (Drosophila melanogaster)
Activated FGFR [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Klotho bound to FGF23 [plasma membrane] (Drosophila melanogaster)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
bnl [extracellular region]
(Drosophila melanogaster)
Klotho homodimer [plasma membrane]
(Drosophila melanogaster)
Participates
as an input of
FGFR1c binds to Klotho-bound FGF23 (Drosophila melanogaster)
as a component of
FGF23 bound to Klotho and FGFR1c [plasma membrane] (Drosophila melanogaster)
Activated FGFR1c bound to FGF23:Klotho [plasma membrane] (Drosophila melanogaster)
Inferred From
Klotho bound to FGF23 [plasma membrane]
(Homo sapiens)
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