Reactome | cindr [cytosol]

cindr [cytosol]

Stable Identifier

R-DME-182957

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

cytosol

Synonyms

SH3KBP1, A0A0B4KI34

Locations in the PathwayBrowser

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Signal Transduction (Drosophila melanogaster)

- Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
  - Signaling by EGFR (Drosophila melanogaster)
    - EGFR downregulation (Drosophila melanogaster)
      - Assembly of EGFR complex in clathrin-coated vesicles (Drosophila melanogaster)
        
        CIN85:endophilin [cytosol] (Drosophila melanogaster)
        
        SH3KBP1 tetramer [cytosol] (Drosophila melanogaster)
        
        Homologues of SH3KBP1 [cytosol] (Drosophila melanogaster)
        
        cindr [cytosol] (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Drosophila melanogaster)
        
        CIN85:endophilin [cytosol] (Drosophila melanogaster)
        
        SH3KBP1 tetramer [cytosol] (Drosophila melanogaster)
        
        Homologues of SH3KBP1 [cytosol] (Drosophila melanogaster)
        
        cindr [cytosol] (Drosophila melanogaster)
      - Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85 (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Drosophila melanogaster)
        
        CIN85:endophilin [cytosol] (Drosophila melanogaster)
        
        SH3KBP1 tetramer [cytosol] (Drosophila melanogaster)
        
        Homologues of SH3KBP1 [cytosol] (Drosophila melanogaster)
        
        cindr [cytosol] (Drosophila melanogaster)
        
        EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Drosophila melanogaster)
        
        CIN85:endophilin [cytosol] (Drosophila melanogaster)
        
        SH3KBP1 tetramer [cytosol] (Drosophila melanogaster)
        
        Homologues of SH3KBP1 [cytosol] (Drosophila melanogaster)
        
        cindr [cytosol] (Drosophila melanogaster)
      - CBL-mediated ubiquitination of CIN85 (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Drosophila melanogaster)
        
        CIN85:endophilin [cytosol] (Drosophila melanogaster)
        
        SH3KBP1 tetramer [cytosol] (Drosophila melanogaster)
        
        Homologues of SH3KBP1 [cytosol] (Drosophila melanogaster)
        
        cindr [cytosol] (Drosophila melanogaster)
      - CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 (Drosophila melanogaster)
        
        CIN85:endophilin [cytosol] (Drosophila melanogaster)
        
        SH3KBP1 tetramer [cytosol] (Drosophila melanogaster)
        
        Homologues of SH3KBP1 [cytosol] (Drosophila melanogaster)
        
        cindr [cytosol] (Drosophila melanogaster)
        
        EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85 [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Drosophila melanogaster)
        
        CIN85:endophilin [cytosol] (Drosophila melanogaster)
        
        SH3KBP1 tetramer [cytosol] (Drosophila melanogaster)
        
        Homologues of SH3KBP1 [cytosol] (Drosophila melanogaster)
        
        cindr [cytosol] (Drosophila melanogaster)
      - EGFR binds EPS15, EPN1, EPS15L1 (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Drosophila melanogaster)
        
        CIN85:endophilin [cytosol] (Drosophila melanogaster)
        
        SH3KBP1 tetramer [cytosol] (Drosophila melanogaster)
        
        Homologues of SH3KBP1 [cytosol] (Drosophila melanogaster)
        
        cindr [cytosol] (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Drosophila melanogaster)
        
        CIN85:endophilin [cytosol] (Drosophila melanogaster)
        
        SH3KBP1 tetramer [cytosol] (Drosophila melanogaster)
        
        Homologues of SH3KBP1 [cytosol] (Drosophila melanogaster)
        
        cindr [cytosol] (Drosophila melanogaster)
      - EGFR phosphorylates EPS15 (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Drosophila melanogaster)
        
        CIN85:endophilin [cytosol] (Drosophila melanogaster)
        
        SH3KBP1 tetramer [cytosol] (Drosophila melanogaster)
        
        Homologues of SH3KBP1 [cytosol] (Drosophila melanogaster)
        
        cindr [cytosol] (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Drosophila melanogaster)
        
        CIN85:endophilin [cytosol] (Drosophila melanogaster)
        
        SH3KBP1 tetramer [cytosol] (Drosophila melanogaster)
        
        Homologues of SH3KBP1 [cytosol] (Drosophila melanogaster)
        
        cindr [cytosol] (Drosophila melanogaster)
      - PTPN3 dephosphorylates EPS15 (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Drosophila melanogaster)
        
        CIN85:endophilin [cytosol] (Drosophila melanogaster)
        
        SH3KBP1 tetramer [cytosol] (Drosophila melanogaster)
        
        Homologues of SH3KBP1 [cytosol] (Drosophila melanogaster)
        
        cindr [cytosol] (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin [plasma membrane] (Drosophila melanogaster)
        
        CIN85:endophilin [cytosol] (Drosophila melanogaster)
        
        SH3KBP1 tetramer [cytosol] (Drosophila melanogaster)
        
        Homologues of SH3KBP1 [cytosol] (Drosophila melanogaster)
        
        cindr [cytosol] (Drosophila melanogaster)
      - Sprouty sequesters CBL away from active EGFR (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Drosophila melanogaster)
        
        CIN85:endophilin [cytosol] (Drosophila melanogaster)
        
        SH3KBP1 tetramer [cytosol] (Drosophila melanogaster)
        
        Homologues of SH3KBP1 [cytosol] (Drosophila melanogaster)
        
        cindr [cytosol] (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:SPRY1/2:Endophilin:Epsin:Eps15L1:EPS15 [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Drosophila melanogaster)
        
        CIN85:endophilin [cytosol] (Drosophila melanogaster)
        
        SH3KBP1 tetramer [cytosol] (Drosophila melanogaster)
        
        Homologues of SH3KBP1 [cytosol] (Drosophila melanogaster)
        
        cindr [cytosol] (Drosophila melanogaster)

Vesicle-mediated transport (Drosophila melanogaster)

- Membrane Trafficking (Drosophila melanogaster)
  - Clathrin-mediated endocytosis (Drosophila melanogaster)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        CIN85:endophilin [cytosol] (Drosophila melanogaster)
        
        SH3KBP1 tetramer [cytosol] (Drosophila melanogaster)
        
        Homologues of SH3KBP1 [cytosol] (Drosophila melanogaster)
        
        cindr [cytosol] (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        CIN85:endophilin [cytosol] (Drosophila melanogaster)
        
        SH3KBP1 tetramer [cytosol] (Drosophila melanogaster)
        
        Homologues of SH3KBP1 [cytosol] (Drosophila melanogaster)
        
        cindr [cytosol] (Drosophila melanogaster)
    - BAR domain proteins recruit dynamin (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Drosophila melanogaster)
        
        CIN85:endophilin [cytosol] (Drosophila melanogaster)
        
        SH3KBP1 tetramer [cytosol] (Drosophila melanogaster)
        
        Homologues of SH3KBP1 [cytosol] (Drosophila melanogaster)
        
        cindr [cytosol] (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Drosophila melanogaster)
        
        CIN85:endophilin [cytosol] (Drosophila melanogaster)
        
        SH3KBP1 tetramer [cytosol] (Drosophila melanogaster)
        
        Homologues of SH3KBP1 [cytosol] (Drosophila melanogaster)
        
        cindr [cytosol] (Drosophila melanogaster)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Drosophila melanogaster)
      - CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Drosophila melanogaster)
        
        CIN85:endophilin [cytosol] (Drosophila melanogaster)
        
        SH3KBP1 tetramer [cytosol] (Drosophila melanogaster)
        
        Homologues of SH3KBP1 [cytosol] (Drosophila melanogaster)
        
        cindr [cytosol] (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Drosophila melanogaster)
        
        CIN85:endophilin [cytosol] (Drosophila melanogaster)
        
        SH3KBP1 tetramer [cytosol] (Drosophila melanogaster)
        
        Homologues of SH3KBP1 [cytosol] (Drosophila melanogaster)
        
        cindr [cytosol] (Drosophila melanogaster)
    - Cargo recognition for clathrin-mediated endocytosis (Drosophila melanogaster)
      - Epsin family proteins bind ubiquitinated cargo (Drosophila melanogaster)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Drosophila melanogaster)
        
        CIN85:endophilin [cytosol] (Drosophila melanogaster)
        
        SH3KBP1 tetramer [cytosol] (Drosophila melanogaster)
        
        Homologues of SH3KBP1 [cytosol] (Drosophila melanogaster)
        
        cindr [cytosol] (Drosophila melanogaster)
        
        ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Drosophila melanogaster)
        
        CIN85:endophilin [cytosol] (Drosophila melanogaster)
        
        SH3KBP1 tetramer [cytosol] (Drosophila melanogaster)
        
        Homologues of SH3KBP1 [cytosol] (Drosophila melanogaster)
        
        cindr [cytosol] (Drosophila melanogaster)
    - Clathrin recruits PIK3C2A (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Drosophila melanogaster)
        
        CIN85:endophilin [cytosol] (Drosophila melanogaster)
        
        SH3KBP1 tetramer [cytosol] (Drosophila melanogaster)
        
        Homologues of SH3KBP1 [cytosol] (Drosophila melanogaster)
        
        cindr [cytosol] (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Drosophila melanogaster)
        
        CIN85:endophilin [cytosol] (Drosophila melanogaster)
        
        SH3KBP1 tetramer [cytosol] (Drosophila melanogaster)
        
        Homologues of SH3KBP1 [cytosol] (Drosophila melanogaster)
        
        cindr [cytosol] (Drosophila melanogaster)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Drosophila melanogaster)
        
        CIN85:endophilin [cytosol] (Drosophila melanogaster)
        
        SH3KBP1 tetramer [cytosol] (Drosophila melanogaster)
        
        Homologues of SH3KBP1 [cytosol] (Drosophila melanogaster)
        
        cindr [cytosol] (Drosophila melanogaster)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        CIN85:endophilin [cytosol] (Drosophila melanogaster)
        
        SH3KBP1 tetramer [cytosol] (Drosophila melanogaster)
        
        Homologues of SH3KBP1 [cytosol] (Drosophila melanogaster)
        
        cindr [cytosol] (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Drosophila melanogaster)
        
        CIN85:endophilin [cytosol] (Drosophila melanogaster)
        
        SH3KBP1 tetramer [cytosol] (Drosophila melanogaster)
        
        Homologues of SH3KBP1 [cytosol] (Drosophila melanogaster)
        
        cindr [cytosol] (Drosophila melanogaster)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Drosophila melanogaster)
        
        CIN85:endophilin [cytosol] (Drosophila melanogaster)
        
        SH3KBP1 tetramer [cytosol] (Drosophila melanogaster)
        
        Homologues of SH3KBP1 [cytosol] (Drosophila melanogaster)
        
        cindr [cytosol] (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Drosophila melanogaster)
        
        CIN85:endophilin [cytosol] (Drosophila melanogaster)
        
        SH3KBP1 tetramer [cytosol] (Drosophila melanogaster)
        
        Homologues of SH3KBP1 [cytosol] (Drosophila melanogaster)
        
        cindr [cytosol] (Drosophila melanogaster)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Drosophila melanogaster)
        
        CIN85:endophilin [cytosol] (Drosophila melanogaster)
        
        SH3KBP1 tetramer [cytosol] (Drosophila melanogaster)
        
        Homologues of SH3KBP1 [cytosol] (Drosophila melanogaster)
        
        cindr [cytosol] (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Drosophila melanogaster)
        
        CIN85:endophilin [cytosol] (Drosophila melanogaster)
        
        SH3KBP1 tetramer [cytosol] (Drosophila melanogaster)
        
        Homologues of SH3KBP1 [cytosol] (Drosophila melanogaster)
        
        cindr [cytosol] (Drosophila melanogaster)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        CIN85:endophilin [cytosol] (Drosophila melanogaster)
        
        SH3KBP1 tetramer [cytosol] (Drosophila melanogaster)
        
        Homologues of SH3KBP1 [cytosol] (Drosophila melanogaster)
        
        cindr [cytosol] (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
        
        CIN85:endophilin [cytosol] (Drosophila melanogaster)
        
        SH3KBP1 tetramer [cytosol] (Drosophila melanogaster)
        
        Homologues of SH3KBP1 [cytosol] (Drosophila melanogaster)
        
        cindr [cytosol] (Drosophila melanogaster)
    - SNX9 recruits components of the actin polymerizing machinery (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Drosophila melanogaster)
        
        CIN85:endophilin [cytosol] (Drosophila melanogaster)
        
        SH3KBP1 tetramer [cytosol] (Drosophila melanogaster)
        
        Homologues of SH3KBP1 [cytosol] (Drosophila melanogaster)
        
        cindr [cytosol] (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Drosophila melanogaster)
        
        CIN85:endophilin [cytosol] (Drosophila melanogaster)
        
        SH3KBP1 tetramer [cytosol] (Drosophila melanogaster)
        
        Homologues of SH3KBP1 [cytosol] (Drosophila melanogaster)
        
        cindr [cytosol] (Drosophila melanogaster)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Drosophila melanogaster)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Drosophila melanogaster)
        
        CIN85:endophilin [cytosol] (Drosophila melanogaster)
        
        SH3KBP1 tetramer [cytosol] (Drosophila melanogaster)
        
        Homologues of SH3KBP1 [cytosol] (Drosophila melanogaster)
        
        cindr [cytosol] (Drosophila melanogaster)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        ubiquitinated cargo [plasma membrane] (Drosophila melanogaster)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Drosophila melanogaster)
        
        CIN85:endophilin [cytosol] (Drosophila melanogaster)
        
        SH3KBP1 tetramer [cytosol] (Drosophila melanogaster)
        
        Homologues of SH3KBP1 [cytosol] (Drosophila melanogaster)
        
        cindr [cytosol] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:A0A0B4KI34

Gene Names

cindr

Reference Genes

BioGPS Gene:43654 cindr

CTD Gene:43654 cindr

ENSEMBL:FBgn0027598

Flybase:FBgn0027598

Monarch:43654 cindr

NCBI Gene:43654 cindr

Reference Transcript

RefSeq:NM_001276200.1 cindr

Other Identifiers

150911_at

151904_at

1633711_a_at

1640850_at

43654

GO:0000910

GO:0001745

GO:0005515

GO:0005576

GO:0005622

GO:0005737

GO:0005886

GO:0007010

GO:0007015

GO:0007298

GO:0016192

GO:0016477

GO:0017124

GO:0022414

GO:0030154

GO:0030496

GO:0032154

GO:0032465

GO:0034330

GO:0034333

GO:0043063

GO:0045171

GO:0045179

GO:0048260

GO:0048749

GO:0048856

GO:0048870

GO:0050839

Participates

as a member of

Homologues of SH3KBP1 [cytosol] (Drosophila melanogaster)

Other forms of this molecule

cindr [endocytic vesicle membrane]

cindr [plasma membrane]

cindr [cytosol]

Inferred From

SH3KBP1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001263129.1

Flybase

FBgn0027598

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