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AP-2alpha [cytosol]
Stable Identifier
R-DME-182155
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
AP2A2(1-939), P91926
Locations in the PathwayBrowser
Expand all
Developmental Biology (Drosophila melanogaster)
Nervous system development (Drosophila melanogaster)
Axon guidance (Drosophila melanogaster)
EPH-Ephrin signaling (Drosophila melanogaster)
EPH-ephrin mediated repulsion of cells (Drosophila melanogaster)
Clathrin internalises EPH:EFN complexes (Drosophila melanogaster)
AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
EPHB:EFNB:F-actin:AP-2:Clathrrin:Dynamin [plasma membrane] (Drosophila melanogaster)
AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
Signal Transduction (Drosophila melanogaster)
Signaling by WNT (Drosophila melanogaster)
Beta-catenin independent WNT signaling (Drosophila melanogaster)
PCP/CE pathway (Drosophila melanogaster)
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 (Drosophila melanogaster)
FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Drosophila melanogaster)
clathrin:AP-2 [plasma membrane] (Drosophila melanogaster)
AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
WNT5A-dependent internalization of FZD4 (Drosophila melanogaster)
WNT5A:FZD4 is endocytosed (Drosophila melanogaster)
WNT5A:FZD4:p-DVL2:ARRB2:AP-2:clathrin [plasma membrane] (Drosophila melanogaster)
clathrin:AP-2 [plasma membrane] (Drosophila melanogaster)
AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
Vesicle-mediated transport (Drosophila melanogaster)
Membrane Trafficking (Drosophila melanogaster)
Clathrin-mediated endocytosis (Drosophila melanogaster)
AAK1 phosphorylates AP-2 mu subunit at T156 (Drosophila melanogaster)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Drosophila melanogaster)
AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Drosophila melanogaster)
AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Drosophila melanogaster)
p-T156 AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Drosophila melanogaster)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
Clathrin-coated vesicle [cytosol] (Drosophila melanogaster)
AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
p-T156 AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
Clathrin-coated vesicle [cytosol] (Drosophila melanogaster)
AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
p-T156 AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
BAR domain proteins recruit dynamin (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
AP-2:cargo [plasma membrane] (Drosophila melanogaster)
AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
p-T156 AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
AP-2:cargo [plasma membrane] (Drosophila melanogaster)
AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
p-T156 AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
AP-2:cargo [plasma membrane] (Drosophila melanogaster)
AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Drosophila melanogaster)
p-T156 AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
AP-2:cargo [plasma membrane] (Drosophila melanogaster)
AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Drosophila melanogaster)
p-T156 AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
Cargo recognition for clathrin-mediated endocytosis (Drosophila melanogaster)
AP-2 directly binds some endocytic cargo (Drosophila melanogaster)
AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
AP-2:cargo [plasma membrane] (Drosophila melanogaster)
AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
AP2:chlorpromazine [cytosol] (Drosophila melanogaster)
AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
AP2 binds chlorpromazine (Drosophila melanogaster)
AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
AP2:chlorpromazine [cytosol] (Drosophila melanogaster)
AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
ARBB recruits GPCRs into clathrin-coated pits (Drosophila melanogaster)
ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Drosophila melanogaster)
p-T156 AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Drosophila melanogaster)
p-T156 AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
Clathrin recruits PIK3C2A (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
AP-2:cargo [plasma membrane] (Drosophila melanogaster)
AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Drosophila melanogaster)
p-T156 AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
AP-2:cargo [plasma membrane] (Drosophila melanogaster)
AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Drosophila melanogaster)
p-T156 AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
AP-2:cargo [plasma membrane] (Drosophila melanogaster)
AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Drosophila melanogaster)
p-T156 AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Drosophila melanogaster)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
Clathrin-coated vesicle [cytosol] (Drosophila melanogaster)
AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
p-T156 AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
AP-2:cargo [plasma membrane] (Drosophila melanogaster)
AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
p-T156 AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
Endophilins recruit synaptojanins to the clathrin-coated pit (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
AP-2:cargo [plasma membrane] (Drosophila melanogaster)
AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
p-T156 AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
AP-2:cargo [plasma membrane] (Drosophila melanogaster)
AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
p-T156 AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
F- and N- BAR domain proteins bind the clathrin-coated pit (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
AP-2:cargo [plasma membrane] (Drosophila melanogaster)
AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Drosophila melanogaster)
p-T156 AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
AP-2:cargo [plasma membrane] (Drosophila melanogaster)
AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
p-T156 AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Drosophila melanogaster)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
Clathrin-coated vesicle [cytosol] (Drosophila melanogaster)
AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
p-T156 AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
Clathrin-coated vesicle [cytosol] (Drosophila melanogaster)
AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
p-T156 AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
Initial binding of AP-2 and clathrin to PI(4,5)P2 (Drosophila melanogaster)
AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
PI(4,5)P2:AP-2:clathrin [plasma membrane] (Drosophila melanogaster)
AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
RAB5 and GAPVD1 bind AP-2 (Drosophila melanogaster)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
ubiquitinated cargo [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)
Clathrin-coated vesicle [cytosol] (Drosophila melanogaster)
AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
p-T156 AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Drosophila melanogaster)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
AP-2:cargo [plasma membrane] (Drosophila melanogaster)
AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
p-T156 AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Drosophila melanogaster)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
CLASP proteins:cargo [plasma membrane] (Drosophila melanogaster)
AP-2:cargo [plasma membrane] (Drosophila melanogaster)
AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
p-T156 AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2alpha [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:P91926
Gene Names
AP-2alpha
Reference Genes
BioGPS Gene:33211 AP-2alpha
CTD Gene:33211 AP-2alpha
ENSEMBL:FBgn0264855
Flybase:FBgn0264855
KEGG Gene (Drosophila melanogaster):Dmel_CG4260 AP-2alpha
Monarch:33211 AP-2alpha
NCBI Gene:33211 AP-2alpha
Reference Transcript
RefSeq:NM_057471.6 AP-2alpha
RefSeq:NM_205885.2 AP-2alpha
Other Identifiers
143820_at
1634403_at
33211
GO:0000278
GO:0000910
GO:0005886
GO:0005905
GO:0006886
GO:0006897
GO:0006898
GO:0006914
GO:0008104
GO:0008356
GO:0010508
GO:0015031
GO:0016020
GO:0016192
GO:0022414
GO:0023052
GO:0030100
GO:0030117
GO:0030122
GO:0030131
GO:0030154
GO:0030707
GO:0031410
GO:0031623
GO:0035615
GO:0038010
GO:0043226
GO:0045807
GO:0048488
GO:0048489
GO:0048856
GO:0060090
GO:0061024
GO:0072583
GO:0098793
GO:0140312
GO:1990386
Participates
as a component of
p-T156 AP-2 Complex [cytosol] (Drosophila melanogaster)
AP-2 Complex [cytosol] (Drosophila melanogaster)
Other forms of this molecule
AP-2alpha [endolysosome membrane]
AP-2alpha [endolysosome membrane]
AP-2alpha [ficolin-1-rich granule membrane]
AP-2alpha [secretory granule membrane]
AP-2alpha [plasma membrane]
AP-2alpha [plasma membrane]
AP-2alpha [endocytic vesicle membrane]
AP-2alpha [endocytic vesicle membrane]
AP-2alpha [clathrin-coated endocytic vesicle membrane]
AP-2alpha [clathrin-coated endocytic vesicle membrane]
AP-2alpha [cytosol]
Inferred From
Adaptor protein complex 2 (AP-2) large adaptins [cytosol]
(Homo sapiens)
AP2A2(1-939) [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_476819.2
,
NP_995607.1
Flybase
FBgn0264855
PRO
P91926
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P16554 NUMB
0.508
3
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