Reactome | Hus1-like [nucleoplasm]

Hus1-like [nucleoplasm]

Stable Identifier

R-DME-176374

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

nucleoplasm

Synonyms

HUS1, Q9VN60

Locations in the PathwayBrowser

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DNA Repair (Drosophila melanogaster)

- DNA Double-Strand Break Repair (Drosophila melanogaster)
  - Homology Directed Repair (Drosophila melanogaster)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Drosophila melanogaster)
      - Processing of DNA double-strand break ends (Drosophila melanogaster)
        
        ATR phosphorylates RPA2 (Drosophila melanogaster)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Drosophila melanogaster)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Drosophila melanogaster)
        
        Hus1-like [nucleoplasm] (Drosophila melanogaster)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Drosophila melanogaster)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Drosophila melanogaster)
        
        Hus1-like [nucleoplasm] (Drosophila melanogaster)
        
        Activation of CHEK1 at resected DNA DSBs (Drosophila melanogaster)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Drosophila melanogaster)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Drosophila melanogaster)
        
        Hus1-like [nucleoplasm] (Drosophila melanogaster)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Drosophila melanogaster)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Drosophila melanogaster)
        
        Hus1-like [nucleoplasm] (Drosophila melanogaster)
        
        CHEK1 is recruited to resected DNA DSBs (Drosophila melanogaster)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Drosophila melanogaster)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Drosophila melanogaster)
        
        Hus1-like [nucleoplasm] (Drosophila melanogaster)
        
        ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Drosophila melanogaster)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Drosophila melanogaster)
        
        Hus1-like [nucleoplasm] (Drosophila melanogaster)

Gene expression (Transcription) (Drosophila melanogaster)

- RNA Polymerase II Transcription (Drosophila melanogaster)
  - Generic Transcription Pathway (Drosophila melanogaster)
    - Transcriptional Regulation by TP53 (Drosophila melanogaster)
      - Regulation of TP53 Activity (Drosophila melanogaster)
        
        Regulation of TP53 Activity through Phosphorylation (Drosophila melanogaster)
        
        ATR phosphorylates TP53 (Drosophila melanogaster)
        
        ATR:ATRIP:RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] (Drosophila melanogaster)
        
        RAD9:HUS1:RAD1 [nucleoplasm] (Drosophila melanogaster)
        
        Hus1-like [nucleoplasm] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q9VN60

Gene Names

Hus1-like

Reference Genes

BioGPS Gene:40598 Hus1-like

CTD Gene:40598 Hus1-like

ENSEMBL:FBgn0026417

Flybase:FBgn0026417

KEGG Gene (Drosophila melanogaster):Dmel_CG2525 Hus1-like

Monarch:40598 Hus1-like

NCBI Gene:40598 Hus1-like

UCSC:Q9VN60 Hus1-like

Reference Transcript

Other Identifiers

144144_at

1627856_at

40598

GO:0000077

GO:0000228

GO:0000278

GO:0000723

GO:0000724

GO:0005634

GO:0005694

GO:0005730

GO:0005737

GO:0006281

GO:0006289

GO:0006310

GO:0022414

GO:0023052

GO:0030154

GO:0030717

GO:0030720

GO:0030896

GO:0031573

GO:0032200

GO:0033314

GO:0035038

GO:0035861

GO:0043226

GO:0044773

GO:0044778

GO:0048856

GO:0051598

GO:0070194

GO:0140013

Participates

as a component of

RAD9:HUS1:RAD1 [nucleoplasm] (Drosophila melanogaster)

Inferred From

HUS1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001262267.1, NP_477426.1

Flybase

FBgn0026417

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