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phospho-Claspin [nucleoplasm]
Stable Identifier
R-DME-176296
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
nucleoplasm
Synonyms
p-T916,S945-CLSPN, Q8IRB5
Locations in the PathwayBrowser
Expand all
Cell Cycle (Drosophila melanogaster)
Cell Cycle Checkpoints (Drosophila melanogaster)
G2/M Checkpoints (Drosophila melanogaster)
Activation of ATR in response to replication stress (Drosophila melanogaster)
Activation of claspin (Drosophila melanogaster)
Cdc45:CDK:DDK:Mcm10:Activated claspin:pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
phospho-Claspin [nucleoplasm] (Drosophila melanogaster)
DNA Repair (Drosophila melanogaster)
DNA Double-Strand Break Repair (Drosophila melanogaster)
Homology Directed Repair (Drosophila melanogaster)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Drosophila melanogaster)
Processing of DNA double-strand break ends (Drosophila melanogaster)
Activation of CHEK1 at resected DNA DSBs (Drosophila melanogaster)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Drosophila melanogaster)
phospho-Claspin [nucleoplasm] (Drosophila melanogaster)
phospho-Claspin [nucleoplasm] (Drosophila melanogaster)
CHEK1 is recruited to resected DNA DSBs (Drosophila melanogaster)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Drosophila melanogaster)
phospho-Claspin [nucleoplasm] (Drosophila melanogaster)
phospho-Claspin [nucleoplasm] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q8IRB5
Gene Names
Claspin
Reference Genes
BioGPS Gene:326205 Claspin
CTD Gene:326205 Claspin
ENSEMBL:FBgn0052251
FlyBase:FBgn0052251
KEGG Gene (Drosophila melanogaster):Dmel_CG32251 Claspin
Monarch:326205 Claspin
NCBI Gene:326205 Claspin
UCSC:Q8IRB5 Claspin
Reference Transcript
RefSeq:NM_168080.2 Claspin
RefSeq:NM_001300005.1 Claspin
Other Identifiers
1633138_at
326205
GO:0000278
GO:0003674
GO:0005634
GO:0007049
GO:0007095
GO:0010997
GO:0023052
GO:0032147
GO:0033314
GO:0036211
GO:0043226
Participates
as a component of
Cdc45:CDK:DDK:Mcm10:Activated claspin:pre-replicative complex [nucleoplasm] (Drosophila melanogaster)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Drosophila melanogaster)
as an output of
Activation of CHEK1 at resected DNA DSBs (Drosophila melanogaster)
as an input of
CHEK1 is recruited to resected DNA DSBs (Drosophila melanogaster)
Other forms of this molecule
Claspin [nucleoplasm]
Claspin [nucleoplasm]
Claspin [nucleoplasm]
Inferred From
p-T916,S945-CLSPN [nucleoplasm]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 945 (in Homo sapiens)
Coordinate
945
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 916 (in Homo sapiens)
Coordinate
916
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_001286934.1
,
NP_728981.1
Flybase
FBgn0052251
PRO
Q8IRB5
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