Reactome | Tep2 [extracellular region]

Tep2 [extracellular region]

Stable Identifier

R-DME-166830-2

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

extracellular region

Synonyms

C3b alpha', Q9NFV7

Locations in the PathwayBrowser

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Immune System (Drosophila melanogaster)

- Innate Immune System (Drosophila melanogaster)
  - Complement cascade (Drosophila melanogaster)
    - Initial triggering of complement (Drosophila melanogaster)
      - Alternative complement activation (Drosophila melanogaster)
        
        C3b binds to cell surface (Drosophila melanogaster)
        
        C3b [extracellular region] (Drosophila melanogaster)
        
        Homologues of C3b alpha' [extracellular region] (Drosophila melanogaster)
        
        Tep2 [extracellular region] (Drosophila melanogaster)
        
        Cell surface:C3b [plasma membrane] (Drosophila melanogaster)
        
        C3b [extracellular region] (Drosophila melanogaster)
        
        Homologues of C3b alpha' [extracellular region] (Drosophila melanogaster)
        
        Tep2 [extracellular region] (Drosophila melanogaster)
    - Regulation of Complement cascade (Drosophila melanogaster)
      - CD46 binds C3b (Drosophila melanogaster)
        
        CD46:Cell surface:C3b [plasma membrane] (Drosophila melanogaster)
        
        Cell surface:C3b [plasma membrane] (Drosophila melanogaster)
        
        C3b [extracellular region] (Drosophila melanogaster)
        
        Homologues of C3b alpha' [extracellular region] (Drosophila melanogaster)
        
        Tep2 [extracellular region] (Drosophila melanogaster)
        
        Cell surface:C3b [plasma membrane] (Drosophila melanogaster)
        
        C3b [extracellular region] (Drosophila melanogaster)
        
        Homologues of C3b alpha' [extracellular region] (Drosophila melanogaster)
        
        Tep2 [extracellular region] (Drosophila melanogaster)
      - Complement factor I binds to MCP, CR1:C4b, C3b (Drosophila melanogaster)
        
        CD46, CR1:C4b:C3b complexes [plasma membrane] (Drosophila melanogaster)
        
        CD46:Cell surface:C3b [plasma membrane] (Drosophila melanogaster)
        
        Cell surface:C3b [plasma membrane] (Drosophila melanogaster)
        
        C3b [extracellular region] (Drosophila melanogaster)
        
        Homologues of C3b alpha' [extracellular region] (Drosophila melanogaster)
        
        Tep2 [extracellular region] (Drosophila melanogaster)
        
        CR1:C3b [plasma membrane] (Drosophila melanogaster)
        
        C3b [extracellular region] (Drosophila melanogaster)
        
        Homologues of C3b alpha' [extracellular region] (Drosophila melanogaster)
        
        Tep2 [extracellular region] (Drosophila melanogaster)
        
        CFI:CD46, CR1:C4b, C3b complexes [plasma membrane] (Drosophila melanogaster)
        
        CD46, CR1:C4b:C3b complexes [plasma membrane] (Drosophila melanogaster)
        
        CD46:Cell surface:C3b [plasma membrane] (Drosophila melanogaster)
        
        Cell surface:C3b [plasma membrane] (Drosophila melanogaster)
        
        C3b [extracellular region] (Drosophila melanogaster)
        
        Homologues of C3b alpha' [extracellular region] (Drosophila melanogaster)
        
        Tep2 [extracellular region] (Drosophila melanogaster)
        
        CR1:C3b [plasma membrane] (Drosophila melanogaster)
        
        C3b [extracellular region] (Drosophila melanogaster)
        
        Homologues of C3b alpha' [extracellular region] (Drosophila melanogaster)
        
        Tep2 [extracellular region] (Drosophila melanogaster)
      - Factor I inactivates MCP/CR1-bound C4b/C3b (Drosophila melanogaster)
        
        CFI:CD46, CR1:C4b, C3b complexes [plasma membrane] (Drosophila melanogaster)
        
        CD46, CR1:C4b:C3b complexes [plasma membrane] (Drosophila melanogaster)
        
        CD46:Cell surface:C3b [plasma membrane] (Drosophila melanogaster)
        
        Cell surface:C3b [plasma membrane] (Drosophila melanogaster)
        
        C3b [extracellular region] (Drosophila melanogaster)
        
        Homologues of C3b alpha' [extracellular region] (Drosophila melanogaster)
        
        Tep2 [extracellular region] (Drosophila melanogaster)
        
        CR1:C3b [plasma membrane] (Drosophila melanogaster)
        
        C3b [extracellular region] (Drosophila melanogaster)
        
        Homologues of C3b alpha' [extracellular region] (Drosophila melanogaster)
        
        Tep2 [extracellular region] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:Q9NFV7

Gene Names

Tep2

Reference Genes

BioGPS Gene:34044 Tep2

CTD Gene:34044 Tep2

ENSEMBL:FBgn0041182

Flybase:FBgn0041182

KEGG Gene (Drosophila melanogaster):Dmel_CG7052 Tep2

Monarch:34044 Tep2

NCBI Gene:34044 Tep2

UCSC:Q9NFV7 Tep2

Reference Transcript

RefSeq:NM_078782.3 Tep2

Other Identifiers

34044

GO:0002376

GO:0003674

GO:0004866

GO:0005575

GO:0005576

GO:0005615

GO:0006950

GO:0008150

GO:0010951

GO:0030234

GO:0045087

GO:0050829

Participates

as a member of

Homologues of C3b alpha' [extracellular region] (Drosophila melanogaster)

Other forms of this molecule

Tep2 [extracellular region]

Tep2 [plasma membrane]

Tep2 [extracellular region]

Tep2 [platelet alpha granule lumen]

Tep2 [plasma membrane]

Tep2 [platelet alpha granule membrane]

Tep2 [extracellular region]

Tep2 [endoplasmic reticulum lumen]

phospho-Tep2 [endoplasmic reticulum lumen]

Tep2 [secretory granule lumen]

Tep2 [azurophil granule lumen]

Tep2 [extracellular region]

Tep2 [plasma membrane]

Inferred From

C3b alpha' [extracellular region] (Homo sapiens)

Cross References

RefSeq

NP_523506.1

Flybase

FBgn0041182