Drosophila NICD traffics to nucleus

Stable Identifier
R-DME-159111
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
cytosol, nucleoplasm
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Drosophila NICD traffics to nucleus

NICD translocates to the nucleus and assembles into a ternary complex with the CSL (human RBPJ i.e. CBF1/ fly Suppressor of Hairless/ worm Lag1) DNA-binding protein and the Mastermind co-activator. This complex activates the transcription of downstream gene targets like HES (Hairy/Enhancer of Split) and HES-related (HRT, also named CHF, HEY, HESR, gridlock) genes.

Literature References
PubMed ID Title Journal Year
9651681 Indirect evidence for Delta-dependent intracellular processing of notch in Drosophila embryos

Lecourtois, M, Schweisguth, F

Curr Biol 1998
9604939 Nuclear access and action of notch in vivo

Struhl, G, Adachi, A

Cell 1998
Participants
Input
Output
Orthologous Events
NICD3 traffics to the nucleus (Homo sapiens)
NICD1 traffics to nucleus (Homo sapiens)
NICD2 traffics to the nucleus (Homo sapiens)
Authored
Jassal, B  (2005-01-10)
Reviewed
Jensen, J  (2008-05-12)
Created
Jassal, B  (2004-12-15)