NICD translocates to the nucleus and assembles into a ternary complex with the CSL (human RBPJ i.e. CBF1/ fly Suppressor of Hairless/ worm Lag1) DNA-binding protein and the Mastermind co-activator. This complex activates the transcription of downstream gene targets like HES (Hairy/Enhancer of Split) and HES-related (HRT, also named CHF, HEY, HESR, gridlock) genes.
Lecourtois, M, Schweisguth, F
Struhl, G, Adachi, A
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