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CHEK1 [nucleoplasm]
Stable Identifier
R-DME-113826
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
nucleoplasm
Synonyms
O61661
Locations in the PathwayBrowser
Expand all
Cell Cycle (Drosophila melanogaster)
Cell Cycle Checkpoints (Drosophila melanogaster)
G2/M Checkpoints (Drosophila melanogaster)
Activation of ATR in response to replication stress (Drosophila melanogaster)
Recruitment and activation of Chk1 (Drosophila melanogaster)
CHEK1 [nucleoplasm] (Drosophila melanogaster)
G2/M DNA damage checkpoint (Drosophila melanogaster)
Recruitment and activation of Chk1 (Drosophila melanogaster)
CHEK1 [nucleoplasm] (Drosophila melanogaster)
DNA Repair (Drosophila melanogaster)
DNA Double-Strand Break Repair (Drosophila melanogaster)
Homology Directed Repair (Drosophila melanogaster)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Drosophila melanogaster)
Processing of DNA double-strand break ends (Drosophila melanogaster)
Activation of CHEK1 at resected DNA DSBs (Drosophila melanogaster)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Drosophila melanogaster)
CHEK1 [nucleoplasm] (Drosophila melanogaster)
CHEK1 is recruited to resected DNA DSBs (Drosophila melanogaster)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Drosophila melanogaster)
CHEK1 [nucleoplasm] (Drosophila melanogaster)
CHEK1 [nucleoplasm] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:O61661
Reference Genes
BioGPS Gene:34993
ENSEMBL:FBgn0261278
Flybase:FBgn0261278
KEGG Gene (Drosophila melanogaster):Dmel_CG17161
Monarch:34993
NCBI Gene:34993
UCSC:O61661
Reference Transcript
RefSeq:NM_165172.3
RefSeq:NM_057663.4
RefSeq:NM_165171.3
Other Identifiers
154999_at
1632423_at
1634230_s_at
34993
GO:0000077
GO:0000166
GO:0000278
GO:0003824
GO:0004672
GO:0004674
GO:0005524
GO:0005634
GO:0005829
GO:0006468
GO:0006974
GO:0007010
GO:0007049
GO:0007059
GO:0007348
GO:0016301
GO:0016310
GO:0016740
GO:0023052
GO:0033314
GO:0035556
GO:0036211
GO:0042060
GO:0043226
GO:0048856
GO:0051225
GO:0051299
GO:0051726
GO:0106310
GO:0140096
Participates
as an input of
Recruitment and activation of Chk1 (Drosophila melanogaster)
CHEK1 is recruited to resected DNA DSBs (Drosophila melanogaster)
as a component of
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Drosophila melanogaster)
Other forms of this molecule
CHEK1 [cytosol]
phospho-p-S317,S345-CHEK1 [nucleoplasm]
Inferred From
CHEK1 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_477011.1
,
NP_723985.1
,
NP_723986.1
Flybase
FBgn0261278
PRO
O61661
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