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Cbl [cytosol]
Stable Identifier
R-DME-112199
Type
Protein [EntityWithAccessionedSequence]
Species
Drosophila melanogaster
Compartment
cytosol
Synonyms
CBL, Q9VSK2
Locations in the PathwayBrowser
Expand all
Signal Transduction (Drosophila melanogaster)
Signaling by Non-Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by PTK6 (Drosophila melanogaster)
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 (Drosophila melanogaster)
PTK6 phosphorylates CBL (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by EGFR (Drosophila melanogaster)
EGFR downregulation (Drosophila melanogaster)
CBL binds to GRB2 (Drosophila melanogaster)
CBL:GRB2 [cytosol] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
CBL:GRB2 [cytosol] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
CBL ubiquitinates Sprouty (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:CBL:Ub-p-Y53/55-SPRY1/2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:CBL:p-Y53/55-SPRY1/2 [plasma membrane] (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
CBL-mediated ubiquitination of CIN85 (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
CDC42:GTP binds CBL:Beta-Pix (Drosophila melanogaster)
CBL:Beta-Pix:CDC42:GTP [cytosol] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Phosphorylation of CBL (EGFR:GRB2:CBL) (Drosophila melanogaster)
EGF-like ligands:p-6Y-EGFR:CBL:GRB2 [plasma membrane] (Drosophila melanogaster)
CBL:GRB2 [cytosol] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Sprouty lures CBL away from EGFR (Drosophila melanogaster)
CBL:SPRY1/2 [cytosol] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Signaling by FGFR (Drosophila melanogaster)
Signaling by FGFR1 (Drosophila melanogaster)
Negative regulation of FGFR1 signaling (Drosophila melanogaster)
Spry regulation of FGF signaling (Drosophila melanogaster)
CBL dissociates from ubiquitinated p-SPRY2 (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Phosphorylated SPRY2 is ubiquitinated by CBL (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
SPRY2 binds CBL (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Signaling by FGFR2 (Drosophila melanogaster)
Negative regulation of FGFR2 signaling (Drosophila melanogaster)
Spry regulation of FGF signaling (Drosophila melanogaster)
CBL dissociates from ubiquitinated p-SPRY2 (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Phosphorylated SPRY2 is ubiquitinated by CBL (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
SPRY2 binds CBL (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Signaling by FGFR3 (Drosophila melanogaster)
Negative regulation of FGFR3 signaling (Drosophila melanogaster)
Spry regulation of FGF signaling (Drosophila melanogaster)
CBL dissociates from ubiquitinated p-SPRY2 (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Phosphorylated SPRY2 is ubiquitinated by CBL (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
SPRY2 binds CBL (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Signaling by FGFR4 (Drosophila melanogaster)
Negative regulation of FGFR4 signaling (Drosophila melanogaster)
Spry regulation of FGF signaling (Drosophila melanogaster)
CBL dissociates from ubiquitinated p-SPRY2 (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Phosphorylated SPRY2 is ubiquitinated by CBL (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
SPRY2 binds CBL (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Y55/Y227-pSPRY2:CBL [plasma membrane] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Signaling by SCF-KIT (Drosophila melanogaster)
Regulation of KIT signaling (Drosophila melanogaster)
Recruitment of CBL to KIT (Drosophila melanogaster)
CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
Cbl [cytosol] (Drosophila melanogaster)
External Reference Information
External Reference
UniProt:Q9VSK2
Gene Names
Cbl
Reference Genes
BioGPS Gene:38961 Cbl
ENSEMBL:FBgn0020224
Flybase:FBgn0020224
KEGG Gene (Drosophila melanogaster):Dmel_CG7037 Cbl
Monarch:38961 Cbl
NCBI Gene:38961 Cbl
UCSC:Q9VSK2 Cbl
Reference Transcript
RefSeq:NM_139967.2 Cbl
Other Identifiers
148403_at
1635580_at
38961
GO:0000003
GO:0001754
GO:0001784
GO:0003674
GO:0004842
GO:0005509
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005886
GO:0005938
GO:0006464
GO:0006511
GO:0006513
GO:0006810
GO:0007165
GO:0007166
GO:0007175
GO:0007465
GO:0007476
GO:0008069
GO:0008150
GO:0008219
GO:0008270
GO:0008283
GO:0009056
GO:0009058
GO:0009950
GO:0009953
GO:0016192
GO:0016567
GO:0016740
GO:0016746
GO:0016874
GO:0017124
GO:0019899
GO:0023051
GO:0030154
GO:0030971
GO:0032353
GO:0040011
GO:0042059
GO:0042127
GO:0043065
GO:0043167
GO:0045121
GO:0045746
GO:0046872
GO:0047690
GO:0048134
GO:0048260
GO:0048856
GO:0048870
GO:0061630
GO:0070373
GO:1903688
Participant Of
input
CBL binds to GRB2
CDC42:GTP binds CBL:Beta-Pix
PTK6 phosphorylates CBL
Recruitment of CBL to KIT
Sprouty lures CBL away from EGFR
SPRY2 binds CBL
hasComponent
CBL:Beta-Pix:CDC42:GTP [cytosol]
CBL:GRB2 [cytosol]
CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane]
CBL:SPRY1/2 [cytosol]
EGF-like ligands:p-6Y-EGFR:CBL [plasma membrane]
Ub:Y55/Y227-pSPRY2:CBL [plasma membrane]
Y55/Y227-pSPRY2:CBL [plasma membrane]
output
CBL dissociates from ubiquitinated p-SPRY2
Other forms of this molecule
Cbl [cytosol]
phospho-Cbl [plasma membrane]
phospho-Cbl [cytosol]
phospho-Cbl [cytosol]
phospho-Cbl [cytosol]
Inferred From
CBL [cytosol] (Homo sapiens)
Cross References
RefSeq
NP_648224.1
Flybase
FBgn0020224
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