Insulin receptor mediated signaling

Stable Identifier
R-DME-110526
Type
Pathway
Species
Drosophila melanogaster
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser

The insulin/IGF-like signaling (IIS) and TOR pathways are responsible for conveying nutrient signals and regulating growth in Drosophila. Activation of the IIS pathway occurs when insulin-like peptides bind the insulin receptor. Activation of the TOR signaling pathway occurs in the presence of amino acids via an unknown mechanism.

Together, these pathways coordinate cell-autonomous and non cell-autonomous growth responses to nutrients. The exact way these two signaling pathways are coordinated and their outputs balanced are not understood.

Participants
Participates
Authored
Reviewed
Created
Cite Us!