DAkt1-mediated phosphorylation inactivates DFOXO

Stable Identifier
R-DME-110475
Type
Reaction [transition]
Species
Drosophila melanogaster
Compartment
cytosol
ReviewStatus
5/5
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DAkt1-mediated phosphorylation inactivates DFOXO
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DFOXO belongs to the FOXO subfamily of forkhead transcription factors. The FOXO factors regulate genes involved in cell cycle control, cell death and stress responses. Phosphorylation of DFOXO by DAkt1 on three residues (Thr44, Ser190 and Ser259) leads to its cytoplasmic retention and inactivation, inhibiting expression of DFOXO-regulated genes. These include D4EBP, DInR and Chico.
Literature References
PubMed ID Title Journal Year
12893776 Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway.

Ruhf, ML, Puig, O, Marr, MT, Tjian, R

Genes Dev 2003
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Catalyst Activity

protein serine/threonine kinase activity of Activated DAkt1 [cytosol]

Physical Entity
Activated DAkt1 [cytosol] (Drosophila melanogaster)
Activity
protein serine/threonine kinase activity (GO:0004674)
Authored
Jassal, B  (2004-02-11)
Created
Jassal, B  (2004-02-11)
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