Reactome | EIF4A3 [cytosol]

EIF4A3 [cytosol]

Stable Identifier

R-DDI-927868

Type

Protein [EntityWithAccessionedSequence]

Species

Dictyostelium discoideum

Compartment

cytosol

Synonyms

Q55D61

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Dictyostelium discoideum)

- Nonsense-Mediated Decay (NMD) (Dictyostelium discoideum)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Dictyostelium discoideum)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Dictyostelium discoideum)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Dictyostelium discoideum)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Dictyostelium discoideum)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Dictyostelium discoideum)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Dictyostelium discoideum)
        
        EIF4A3 [cytosol] (Dictyostelium discoideum)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Dictyostelium discoideum)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Dictyostelium discoideum)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Dictyostelium discoideum)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Dictyostelium discoideum)
        
        EIF4A3 [cytosol] (Dictyostelium discoideum)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Dictyostelium discoideum)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Dictyostelium discoideum)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Dictyostelium discoideum)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Dictyostelium discoideum)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Dictyostelium discoideum)
        
        EIF4A3 [cytosol] (Dictyostelium discoideum)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Dictyostelium discoideum)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Dictyostelium discoideum)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Dictyostelium discoideum)
        
        EIF4A3 [cytosol] (Dictyostelium discoideum)

External Reference Information

External Reference

UniProt:Q55D61

Reference Genes

BioGPS Gene:8617226

dictyBase:DDB_G0269192

ENSEMBL:DDB_G0269192

KEGG Gene (Dictyostelium discoideum):DDB_G0269192

Monarch:8617226

NCBI Gene:8617226

Reference Transcript

RefSeq:XM_641178.1

Participates

as a component of

Core Exon Junction Complex (Core EJC) [cytosol] (Dictyostelium discoideum)

as a member of

eIF4A [cytosol] (Dictyostelium discoideum)

Other forms of this molecule

EIF4A3 [nucleoplasm]

Inferred From

EIF4A3 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_646270.1

PRO

Q55D61