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PICALMs [cytosol]
Stable Identifier
R-DDI-8867602
Type
Set [CandidateSet]
Species
Dictyostelium discoideum
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Dictyostelium discoideum)
Membrane Trafficking (Dictyostelium discoideum)
Clathrin-mediated endocytosis (Dictyostelium discoideum)
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Dictyostelium discoideum)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Dictyostelium discoideum)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Dictyostelium discoideum)
PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Dictyostelium discoideum)
PICALMs [cytosol] (Dictyostelium discoideum)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Dictyostelium discoideum)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Dictyostelium discoideum)
PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Dictyostelium discoideum)
PICALMs [cytosol] (Dictyostelium discoideum)
BAR domain proteins recruit dynamin (Dictyostelium discoideum)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Dictyostelium discoideum)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Dictyostelium discoideum)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Dictyostelium discoideum)
CLASP proteins:cargo [plasma membrane] (Dictyostelium discoideum)
PICALM:VAMP2,3,8 [plasma membrane] (Dictyostelium discoideum)
PICALMs [cytosol] (Dictyostelium discoideum)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Dictyostelium discoideum)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Dictyostelium discoideum)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Dictyostelium discoideum)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Dictyostelium discoideum)
CLASP proteins:cargo [plasma membrane] (Dictyostelium discoideum)
PICALM:VAMP2,3,8 [plasma membrane] (Dictyostelium discoideum)
PICALMs [cytosol] (Dictyostelium discoideum)
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Dictyostelium discoideum)
CLASP proteins:cargo [plasma membrane] (Dictyostelium discoideum)
PICALM:VAMP2,3,8 [plasma membrane] (Dictyostelium discoideum)
PICALMs [cytosol] (Dictyostelium discoideum)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Dictyostelium discoideum)
CLASP proteins:cargo [plasma membrane] (Dictyostelium discoideum)
PICALM:VAMP2,3,8 [plasma membrane] (Dictyostelium discoideum)
PICALMs [cytosol] (Dictyostelium discoideum)
Cargo recognition for clathrin-mediated endocytosis (Dictyostelium discoideum)
PICALM binds R-SNAREs (Dictyostelium discoideum)
PICALM:VAMP2,3,8 [plasma membrane] (Dictyostelium discoideum)
PICALMs [cytosol] (Dictyostelium discoideum)
PICALMs [cytosol] (Dictyostelium discoideum)
Clathrin recruits PIK3C2A (Dictyostelium discoideum)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Dictyostelium discoideum)
CLASP proteins:cargo [plasma membrane] (Dictyostelium discoideum)
PICALM:VAMP2,3,8 [plasma membrane] (Dictyostelium discoideum)
PICALMs [cytosol] (Dictyostelium discoideum)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Dictyostelium discoideum)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Dictyostelium discoideum)
CLASP proteins:cargo [plasma membrane] (Dictyostelium discoideum)
PICALM:VAMP2,3,8 [plasma membrane] (Dictyostelium discoideum)
PICALMs [cytosol] (Dictyostelium discoideum)
Clathrin recruits auxilins to the clathrin-coated vesicle (Dictyostelium discoideum)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Dictyostelium discoideum)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Dictyostelium discoideum)
PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Dictyostelium discoideum)
PICALMs [cytosol] (Dictyostelium discoideum)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Dictyostelium discoideum)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Dictyostelium discoideum)
PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Dictyostelium discoideum)
PICALMs [cytosol] (Dictyostelium discoideum)
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Dictyostelium discoideum)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Dictyostelium discoideum)
PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Dictyostelium discoideum)
CLASP proteins:cargo [plasma membrane] (Dictyostelium discoideum)
PICALM:VAMP2,3,8 [plasma membrane] (Dictyostelium discoideum)
PICALMs [cytosol] (Dictyostelium discoideum)
Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Dictyostelium discoideum)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Dictyostelium discoideum)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Dictyostelium discoideum)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Dictyostelium discoideum)
PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Dictyostelium discoideum)
PICALMs [cytosol] (Dictyostelium discoideum)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Dictyostelium discoideum)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Dictyostelium discoideum)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Dictyostelium discoideum)
PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Dictyostelium discoideum)
PICALMs [cytosol] (Dictyostelium discoideum)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Dictyostelium discoideum)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Dictyostelium discoideum)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Dictyostelium discoideum)
PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Dictyostelium discoideum)
PICALMs [cytosol] (Dictyostelium discoideum)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Dictyostelium discoideum)
CLASP proteins:cargo [plasma membrane] (Dictyostelium discoideum)
PICALM:VAMP2,3,8 [plasma membrane] (Dictyostelium discoideum)
PICALMs [cytosol] (Dictyostelium discoideum)
Endophilins recruit synaptojanins to the clathrin-coated pit (Dictyostelium discoideum)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Dictyostelium discoideum)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Dictyostelium discoideum)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Dictyostelium discoideum)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Dictyostelium discoideum)
CLASP proteins:cargo [plasma membrane] (Dictyostelium discoideum)
PICALM:VAMP2,3,8 [plasma membrane] (Dictyostelium discoideum)
PICALMs [cytosol] (Dictyostelium discoideum)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Dictyostelium discoideum)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Dictyostelium discoideum)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Dictyostelium discoideum)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Dictyostelium discoideum)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Dictyostelium discoideum)
CLASP proteins:cargo [plasma membrane] (Dictyostelium discoideum)
PICALM:VAMP2,3,8 [plasma membrane] (Dictyostelium discoideum)
PICALMs [cytosol] (Dictyostelium discoideum)
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Dictyostelium discoideum)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Dictyostelium discoideum)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Dictyostelium discoideum)
PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Dictyostelium discoideum)
PICALMs [cytosol] (Dictyostelium discoideum)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Dictyostelium discoideum)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Dictyostelium discoideum)
PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Dictyostelium discoideum)
PICALMs [cytosol] (Dictyostelium discoideum)
RAB5 and GAPVD1 bind AP-2 (Dictyostelium discoideum)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Dictyostelium discoideum)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Dictyostelium discoideum)
CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Dictyostelium discoideum)
PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Dictyostelium discoideum)
PICALMs [cytosol] (Dictyostelium discoideum)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Dictyostelium discoideum)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Dictyostelium discoideum)
CLASP proteins:cargo [plasma membrane] (Dictyostelium discoideum)
PICALM:VAMP2,3,8 [plasma membrane] (Dictyostelium discoideum)
PICALMs [cytosol] (Dictyostelium discoideum)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Dictyostelium discoideum)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Dictyostelium discoideum)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Dictyostelium discoideum)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Dictyostelium discoideum)
PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Dictyostelium discoideum)
CLASP proteins:cargo [plasma membrane] (Dictyostelium discoideum)
PICALM:VAMP2,3,8 [plasma membrane] (Dictyostelium discoideum)
PICALMs [cytosol] (Dictyostelium discoideum)
Participants
members
PICALM [cytosol]
(Dictyostelium discoideum)
candidates
SNAP91 [cytosol]
(Dictyostelium discoideum)
Participates
as a component of
PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Dictyostelium discoideum)
PICALM:VAMP2,3,8 [plasma membrane] (Dictyostelium discoideum)
as an input of
PICALM binds R-SNAREs (Dictyostelium discoideum)
Inferred From
PICALMs [cytosol]
(Homo sapiens)
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