Reactome | phospho-H2AX [nucleoplasm]

phospho-H2AX [nucleoplasm]

Stable Identifier

R-DDI-75170-4

Type

Protein [EntityWithAccessionedSequence]

Species

Dictyostelium discoideum

Compartment

nucleoplasm

Synonyms

p-S140-H2AFX, Q54WG6

Locations in the PathwayBrowser

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DNA Repair (Dictyostelium discoideum)

- DNA Double-Strand Break Repair (Dictyostelium discoideum)
  - DNA Double Strand Break Response (Dictyostelium discoideum)
    - Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Dictyostelium discoideum)
      - ATM phosphorylates MDC1 (Dictyostelium discoideum)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:MDC1 [nucleoplasm] (Dictyostelium discoideum)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Dictyostelium discoideum)
        
        p-S139-H2AFX-Nucleosome [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of p-S140-H2AFX [nucleoplasm] (Dictyostelium discoideum)
        
        phospho-H2AX [nucleoplasm] (Dictyostelium discoideum)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1 [nucleoplasm] (Dictyostelium discoideum)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Dictyostelium discoideum)
        
        p-S139-H2AFX-Nucleosome [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of p-S140-H2AFX [nucleoplasm] (Dictyostelium discoideum)
        
        phospho-H2AX [nucleoplasm] (Dictyostelium discoideum)
      - ATM phosphorylates WHSC1 (Dictyostelium discoideum)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:WHSC1 [nucleoplasm] (Dictyostelium discoideum)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1 [nucleoplasm] (Dictyostelium discoideum)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Dictyostelium discoideum)
        
        p-S139-H2AFX-Nucleosome [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of p-S140-H2AFX [nucleoplasm] (Dictyostelium discoideum)
        
        phospho-H2AX [nucleoplasm] (Dictyostelium discoideum)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Dictyostelium discoideum)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1 [nucleoplasm] (Dictyostelium discoideum)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Dictyostelium discoideum)
        
        p-S139-H2AFX-Nucleosome [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of p-S140-H2AFX [nucleoplasm] (Dictyostelium discoideum)
        
        phospho-H2AX [nucleoplasm] (Dictyostelium discoideum)
      - HERC2 facilitates UBE2N:UBE2V2 binding to RNF8 (Dictyostelium discoideum)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:PIAS4 [nucleoplasm] (Dictyostelium discoideum)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Dictyostelium discoideum)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Dictyostelium discoideum)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1 [nucleoplasm] (Dictyostelium discoideum)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Dictyostelium discoideum)
        
        p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of p-S140-H2AFX [nucleoplasm] (Dictyostelium discoideum)
        
        phospho-H2AX [nucleoplasm] (Dictyostelium discoideum)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:PIAS4 [nucleoplasm] (Dictyostelium discoideum)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1 [nucleoplasm] (Dictyostelium discoideum)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Dictyostelium discoideum)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1 [nucleoplasm] (Dictyostelium discoideum)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Dictyostelium discoideum)
        
        p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of p-S140-H2AFX [nucleoplasm] (Dictyostelium discoideum)
        
        phospho-H2AX [nucleoplasm] (Dictyostelium discoideum)
      - MDC1 associates with gamma-H2AFX at nuclear foci (Dictyostelium discoideum)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Dictyostelium discoideum)
        
        p-S139-H2AFX-Nucleosome [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of p-S140-H2AFX [nucleoplasm] (Dictyostelium discoideum)
        
        phospho-H2AX [nucleoplasm] (Dictyostelium discoideum)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:MDC1 [nucleoplasm] (Dictyostelium discoideum)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Dictyostelium discoideum)
        
        p-S139-H2AFX-Nucleosome [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of p-S140-H2AFX [nucleoplasm] (Dictyostelium discoideum)
        
        phospho-H2AX [nucleoplasm] (Dictyostelium discoideum)
      - WHSC1 binds DNA DSBs (Dictyostelium discoideum)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1 [nucleoplasm] (Dictyostelium discoideum)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Dictyostelium discoideum)
        
        p-S139-H2AFX-Nucleosome [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of p-S140-H2AFX [nucleoplasm] (Dictyostelium discoideum)
        
        phospho-H2AX [nucleoplasm] (Dictyostelium discoideum)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:WHSC1 [nucleoplasm] (Dictyostelium discoideum)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1 [nucleoplasm] (Dictyostelium discoideum)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Dictyostelium discoideum)
        
        p-S139-H2AFX-Nucleosome [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of p-S140-H2AFX [nucleoplasm] (Dictyostelium discoideum)
        
        phospho-H2AX [nucleoplasm] (Dictyostelium discoideum)
      - WHSC1 dimethylates histone H4 on lysine K21 at DSBs (Dictyostelium discoideum)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Dictyostelium discoideum)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1 [nucleoplasm] (Dictyostelium discoideum)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Dictyostelium discoideum)
        
        p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of p-S140-H2AFX [nucleoplasm] (Dictyostelium discoideum)
        
        phospho-H2AX [nucleoplasm] (Dictyostelium discoideum)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:p-S102-WHSC1 [nucleoplasm] (Dictyostelium discoideum)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1 [nucleoplasm] (Dictyostelium discoideum)
        
        DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome [nucleoplasm] (Dictyostelium discoideum)
        
        p-S139-H2AFX-Nucleosome [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of p-S140-H2AFX [nucleoplasm] (Dictyostelium discoideum)
        
        phospho-H2AX [nucleoplasm] (Dictyostelium discoideum)

External Reference Information

External Reference

UniProt:Q54WG6

Gene Names

H2AX

Reference Genes

dictyBase:DDB_G0279667

ENSEMBL:DDB_G0279667

KEGG Gene (Dictyostelium discoideum):DDB_G0279667 H2AX

Participant Of

hasMember

Homologues of p-S140-H2AFX [nucleoplasm]

Other forms of this molecule

H2AX [nucleoplasm]

phospho-H2AX [nucleoplasm]

H2AX [nucleoplasm]

Inferred From

p-S140-H2AFX [nucleoplasm] (Homo sapiens)

Modified Residues

Name

O-phospho-L-serine at 140 (in Homo sapiens)

Coordinate

140

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

OpenTargets

ENSG00000188486

PRO

Q54WG6

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