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What is Reactome ?
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CDK7 [nucleoplasm]
Stable Identifier
R-DDI-69218
Type
Protein [EntityWithAccessionedSequence]
Species
Dictyostelium discoideum
Compartment
nucleoplasm
Synonyms
P54685
Locations in the PathwayBrowser
Expand all
DNA Repair (Dictyostelium discoideum)
Nucleotide Excision Repair (Dictyostelium discoideum)
Global Genome Nucleotide Excision Repair (GG-NER) (Dictyostelium discoideum)
Formation of Incision Complex in GG-NER (Dictyostelium discoideum)
TFIIH binds GG-NER site to form a verification complex (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Dictyostelium discoideum)
Dual incision in TC-NER (Dictyostelium discoideum)
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Dictyostelium discoideum)
TC-NER incision complex [nucleoplasm] (Dictyostelium discoideum)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Dictyostelium discoideum)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Dictyostelium discoideum)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Dictyostelium discoideum)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Dictyostelium discoideum)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Dictyostelium discoideum)
TC-NER incision complex [nucleoplasm] (Dictyostelium discoideum)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Dictyostelium discoideum)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Dictyostelium discoideum)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Dictyostelium discoideum)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Dictyostelium discoideum)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Dictyostelium discoideum)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Dictyostelium discoideum)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Dictyostelium discoideum)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Dictyostelium discoideum)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
DNA polymerases delta, epsilon or kappa bind the TC-NER site (Dictyostelium discoideum)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
ERCC2-facilitated RNA Pol II backtracking in TC-NER (Dictyostelium discoideum)
TC-NER pre-incision complex [nucleoplasm] (Dictyostelium discoideum)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Dictyostelium discoideum)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Dictyostelium discoideum)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Dictyostelium discoideum)
Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Dictyostelium discoideum)
Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Dictyostelium discoideum)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
ERCC3-facilitated RNA Pol II backtracking in TC-NER (Dictyostelium discoideum)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Dictyostelium discoideum)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Dictyostelium discoideum)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Dictyostelium discoideum)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Dictyostelium discoideum)
Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Dictyostelium discoideum)
Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Dictyostelium discoideum)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
Formation of TC-NER Pre-Incision Complex (Dictyostelium discoideum)
Active RNA Pol II complex transcribes lesion-containing DNA template (Dictyostelium discoideum)
Damaged dsDNA with open transcription bubble:Hyperphosphorylated RNA Pol II:TFIIH [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
ERCC6 binds stalled RNA Pol II (Dictyostelium discoideum)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Dictyostelium discoideum)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
ERCC8 (CSA) binds stalled RNA Pol II (Dictyostelium discoideum)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Dictyostelium discoideum)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Dictyostelium discoideum)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Dictyostelium discoideum)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Dictyostelium discoideum)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Dictyostelium discoideum)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Dictyostelium discoideum)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Dictyostelium discoideum)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6 [nucleoplasm] (Dictyostelium discoideum)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
RNA Pol II initiates transcription from damaged DNA template (Dictyostelium discoideum)
Damaged dsDNA with open transcription bubble:Hyperphosphorylated RNA Pol II:TFIIH [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
UVSSA:USP7 deubiquitinates ERCC6 (Dictyostelium discoideum)
TC-NER pre-incision complex [nucleoplasm] (Dictyostelium discoideum)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Dictyostelium discoideum)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Dictyostelium discoideum)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Dictyostelium discoideum)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Dictyostelium discoideum)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6 [nucleoplasm] (Dictyostelium discoideum)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
Gap-filling DNA repair synthesis and ligation in TC-NER (Dictyostelium discoideum)
Ligation of newly synthesized repair patch to incised DNA in TC-NER (Dictyostelium discoideum)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Dictyostelium discoideum)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
Gene expression (Transcription) (Dictyostelium discoideum)
RNA Polymerase I Transcription (Dictyostelium discoideum)
RNA Polymerase I Promoter Clearance (Dictyostelium discoideum)
RNA Polymerase I Promoter Escape (Dictyostelium discoideum)
Elongation of pre-rRNA transcript (Dictyostelium discoideum)
RNA Polymerase I promoter escape complex [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
Loss of Rrn3 from RNA Polymerase I promoter escape complex (Dictyostelium discoideum)
RNA Polymerase I Transcription Initiation complex [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
RNA Polymerase I promoter escape complex [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
RNA Polymerase II Transcription (Dictyostelium discoideum)
Generic Transcription Pathway (Dictyostelium discoideum)
Transcriptional Regulation by TP53 (Dictyostelium discoideum)
TP53 Regulates Transcription of DNA Repair Genes (Dictyostelium discoideum)
CCNK:CDK12 binds RNA Pol II at DNA repair genes (Dictyostelium discoideum)
CCNK:CDK12:Elongation Complex at DNA Repair Genes [nucleoplasm] (Dictyostelium discoideum)
Elongation Complex at DNA Repair Genes [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
Elongation Complex at DNA Repair Genes [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
CDK12 phosphorylates RNA Pol II CTD at DNA repair genes (Dictyostelium discoideum)
CCNK:CDK12:CDK12-Phosphorylated Elongation Complex at DNA repair genes [nucleoplasm] (Dictyostelium discoideum)
CDK12-Phosphorylated Elongation Complex [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
CCNK:CDK12:Elongation Complex at DNA Repair Genes [nucleoplasm] (Dictyostelium discoideum)
Elongation Complex at DNA Repair Genes [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
RNA Pol II CTD phosphorylation and interaction with CE (Dictyostelium discoideum)
Activation of GT (Dictyostelium discoideum)
RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Dictyostelium discoideum)
Pol II transcription complex containing extruded transcript to +30 [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
Phosphorylation (Ser5) of RNA pol II CTD (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
Pol II transcription complex containing extruded transcript to +30 [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
Pol II transcription complex with (ser5) phosphorylated CTD containing extruded transcript to +30 [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
RNA Polymerase II CTD (phosphorylated) binds to CE (Dictyostelium discoideum)
Pol II transcription complex with (ser5) phosphorylated CTD containing extruded transcript to +30 [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Dictyostelium discoideum)
CE:Pol II CTD:Spt5 complex [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
RNA Polymerase II Pre-transcription Events (Dictyostelium discoideum)
Abortive Initiation After Second Transition (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
pol II transcription complex containing 4-9 nucleotide long transcript [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
Abortive Initiation Before Second Transition (Dictyostelium discoideum)
Pol II Promoter Escape Complex [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
Abortive initiation after formation of the first phosphodiester bond (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
pol II transcription complex [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
Fall Back to Closed Pre-initiation Complex (Dictyostelium discoideum)
pol II closed pre-initiation complex [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
pol II open pre-initiation complex [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
RNA Polymerase II Transcription Elongation (Dictyostelium discoideum)
Formation of the Early Elongation Complex (Dictyostelium discoideum)
Hypophosphorylation of RNA Pol II CTD by FCP1P protein (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
RNA Polymerase II Transcription Initiation And Promoter Clearance (Dictyostelium discoideum)
RNA Polymerase II Promoter Escape (Dictyostelium discoideum)
Addition of Nucleotides 5 through 9 on the growing Transcript (Dictyostelium discoideum)
pol II transcription complex containing 4 nucleotide long transcript [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
pol II transcription complex containing 9 nucleotide long transcript [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Dictyostelium discoideum)
pol II transcription complex containing 11 nucleotide long transcript [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
pol II transcription complex containing 9 nucleotide long transcript [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
Addition of nucleotides between position +11 and +30 (Dictyostelium discoideum)
Pol II transcription complex containing extruded transcript to +30 [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
pol II transcription complex containing 11 nucleotide long transcript [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
Addition of the fourth nucleotide on the Nascent Transcript: Second Transition (Dictyostelium discoideum)
pol II transcription complex containing 3 Nucleotide long transcript [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
pol II transcription complex containing 4 nucleotide long transcript [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
Addition of the third nucleotide on the nascent transcript (Dictyostelium discoideum)
pol II transcription complex [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
pol II transcription complex containing 3 Nucleotide long transcript [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
Unwinding DNA for the nascent transcript (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
pol II transcription complex [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
Unwinding of DNA for the Nascent Transcript: Second Transition (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
pol II transcription complex containing 3 Nucleotide long transcript [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
RNA Polymerase II Promoter Opening: First Transition (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
pol II closed pre-initiation complex [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
pol II open pre-initiation complex [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
RNA Polymerase II Transcription Initiation (Dictyostelium discoideum)
NTP Binds Active Site of RNA Polymerase II (Dictyostelium discoideum)
Pol II initiation complex [nucleoplasm] (Dictyostelium discoideum)
RNA Polymearse II:NTP:TFIIF complex [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
pol II open pre-initiation complex [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
Newly Formed Phosphodiester Bond Stabilized and PPi Released (Dictyostelium discoideum)
Pol II Initiation complex with phosphodiester-PPi intermediate [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
pol II transcription complex [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP (Dictyostelium discoideum)
Pol II Initiation complex with phosphodiester-PPi intermediate [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
Pol II initiation complex [nucleoplasm] (Dictyostelium discoideum)
RNA Polymearse II:NTP:TFIIF complex [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening (Dictyostelium discoideum)
Formation of the closed pre-initiation complex (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
pol II closed pre-initiation complex [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
RNA polymerase II transcribes snRNA genes (Dictyostelium discoideum)
CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
RNA polymerase II (phosphoserine-5,7):Initiation factors:CDK7:snRNA gene [nucleoplasm] (Dictyostelium discoideum)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
RNA polymerase II (unphosphorylated):Initiation factors at promoter of snRNA gene [nucleoplasm] (Dictyostelium discoideum)
RNA polymerase II (unphosphorylated):Initiation factors [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
Integrator complex processes the 3' end of snRNA (Dictyostelium discoideum)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Dictyostelium discoideum)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Dictyostelium discoideum)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
Pre-snRNA is elongated and capped with 7-methylguanosine (Dictyostelium discoideum)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Dictyostelium discoideum)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Dictyostelium discoideum)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Dictyostelium discoideum)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
RNA polymerase II (unphosphorylated):Initiation factors at promoter of snRNA gene [nucleoplasm] (Dictyostelium discoideum)
RNA polymerase II (unphosphorylated):Initiation factors [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
Metabolism of RNA (Dictyostelium discoideum)
mRNA Capping (Dictyostelium discoideum)
Activation of GT (Dictyostelium discoideum)
RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
Capping complex formation (Dictyostelium discoideum)
CE:Pol II CTD:Spt5 complex [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
Capping complex (initial) [nucleoplasm] (Dictyostelium discoideum)
CE:Pol II CTD:Spt5 complex [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
Dissociation of transcript with 5'-GMP from GT (Dictyostelium discoideum)
Capping complex (GpppN..) [nucleoplasm] (Dictyostelium discoideum)
CE:Pol II CTD:Spt5 complex [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
Capping complex (with freed 5'- GMP) [nucleoplasm] (Dictyostelium discoideum)
CE:Pol II CTD:Spt5 complex [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
Formation of the CE:GMP intermediate complex (Dictyostelium discoideum)
Capping complex (intermediate) [nucleoplasm] (Dictyostelium discoideum)
Covalent CE:GMP intermediate complex [nucleoplasm] (Dictyostelium discoideum)
CE:Pol II CTD:Spt5 complex [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
Capping complex (hydrolyzed) [nucleoplasm] (Dictyostelium discoideum)
CE:Pol II CTD:Spt5 complex [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Dictyostelium discoideum)
Capping complex (hydrolyzed) [nucleoplasm] (Dictyostelium discoideum)
CE:Pol II CTD:Spt5 complex [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
Capping complex (initial) [nucleoplasm] (Dictyostelium discoideum)
CE:Pol II CTD:Spt5 complex [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
Methylation of GMP-cap by RNA Methyltransferase (Dictyostelium discoideum)
Capping complex (with freed 5'- GMP) [nucleoplasm] (Dictyostelium discoideum)
CE:Pol II CTD:Spt5 complex [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
RNA Polymerase II CTD (phosphorylated) binds to CE (Dictyostelium discoideum)
Pol II transcription complex with (ser5) phosphorylated CTD containing extruded transcript to +30 [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Dictyostelium discoideum)
CE:Pol II CTD:Spt5 complex [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Dictyostelium discoideum)
Capping complex (intermediate) [nucleoplasm] (Dictyostelium discoideum)
Covalent CE:GMP intermediate complex [nucleoplasm] (Dictyostelium discoideum)
CE:Pol II CTD:Spt5 complex [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
Capping complex (GpppN..) [nucleoplasm] (Dictyostelium discoideum)
CE:Pol II CTD:Spt5 complex [nucleoplasm] (Dictyostelium discoideum)
TFIIH [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
CDK7 [nucleoplasm] (Dictyostelium discoideum)
External Reference Information
External Reference
UniProt:P54685
Reference Genes
BioGPS Gene:8625277
dictyBase:DDB_G0285417
ENSEMBL:DDB_G0285417
KEGG Gene (Dictyostelium discoideum):DDB_G0285417
Monarch:8625277
NCBI Gene:8625277
Reference Transcript
RefSeq:XM_633137.1
Participates
as a component of
RNA polymerase II (unphosphorylated):Initiation factors [nucleoplasm] (Dictyostelium discoideum)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Dictyostelium discoideum)
CAK [nucleoplasm] (Dictyostelium discoideum)
Inferred From
CDK7 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
XP_638229.1
IntEnz
2.7.11.22
PRO
P54685
© 2024
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