Reactome | FBXW4 [cytosol]

FBXW4 [cytosol]

Stable Identifier

R-DDI-391305

Type

Protein [EntityWithAccessionedSequence]

Species

Dictyostelium discoideum

Compartment

cytosol

Synonyms

Q54UQ3

Locations in the PathwayBrowser

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Immune System (Dictyostelium discoideum)

- Adaptive Immune System (Dictyostelium discoideum)
  - Class I MHC mediated antigen processing & presentation (Dictyostelium discoideum)
    - Antigen processing: Ubiquitination & Proteasome degradation (Dictyostelium discoideum)
      - Interaction of E3 with substrate and E2-Ub complex (Dictyostelium discoideum)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Dictyostelium discoideum)
        
        E3 ligases in proteasomal degradation [cytosol] (Dictyostelium discoideum)
        
        SCF E3 ubiquitin ligase [cytosol] (Dictyostelium discoideum)
        
        F-box protein [cytosol] (Dictyostelium discoideum)
        
        FBXW4 [cytosol] (Dictyostelium discoideum)
        
        E3 ligases in proteasomal degradation [cytosol] (Dictyostelium discoideum)
        
        SCF E3 ubiquitin ligase [cytosol] (Dictyostelium discoideum)
        
        F-box protein [cytosol] (Dictyostelium discoideum)
        
        FBXW4 [cytosol] (Dictyostelium discoideum)
      - Polyubiquitination of substrate (Dictyostelium discoideum)
        
        E3 ligases in proteasomal degradation [cytosol] (Dictyostelium discoideum)
        
        SCF E3 ubiquitin ligase [cytosol] (Dictyostelium discoideum)
        
        F-box protein [cytosol] (Dictyostelium discoideum)
        
        FBXW4 [cytosol] (Dictyostelium discoideum)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Dictyostelium discoideum)
        
        E3 ligases in proteasomal degradation [cytosol] (Dictyostelium discoideum)
        
        SCF E3 ubiquitin ligase [cytosol] (Dictyostelium discoideum)
        
        F-box protein [cytosol] (Dictyostelium discoideum)
        
        FBXW4 [cytosol] (Dictyostelium discoideum)
        
        E3:Ub:substrate [cytosol] (Dictyostelium discoideum)
        
        E3 ligases in proteasomal degradation [cytosol] (Dictyostelium discoideum)
        
        SCF E3 ubiquitin ligase [cytosol] (Dictyostelium discoideum)
        
        F-box protein [cytosol] (Dictyostelium discoideum)
        
        FBXW4 [cytosol] (Dictyostelium discoideum)
      - Release of E3 from polyubiquitinated substrate (Dictyostelium discoideum)
        
        E3 ligases in proteasomal degradation [cytosol] (Dictyostelium discoideum)
        
        SCF E3 ubiquitin ligase [cytosol] (Dictyostelium discoideum)
        
        F-box protein [cytosol] (Dictyostelium discoideum)
        
        FBXW4 [cytosol] (Dictyostelium discoideum)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Dictyostelium discoideum)
        
        E3 ligases in proteasomal degradation [cytosol] (Dictyostelium discoideum)
        
        SCF E3 ubiquitin ligase [cytosol] (Dictyostelium discoideum)
        
        F-box protein [cytosol] (Dictyostelium discoideum)
        
        FBXW4 [cytosol] (Dictyostelium discoideum)
      - Transfer of Ub from E2 to substrate and release of E2 (Dictyostelium discoideum)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Dictyostelium discoideum)
        
        E3 ligases in proteasomal degradation [cytosol] (Dictyostelium discoideum)
        
        SCF E3 ubiquitin ligase [cytosol] (Dictyostelium discoideum)
        
        F-box protein [cytosol] (Dictyostelium discoideum)
        
        FBXW4 [cytosol] (Dictyostelium discoideum)
        
        E3 ligases in proteasomal degradation [cytosol] (Dictyostelium discoideum)
        
        SCF E3 ubiquitin ligase [cytosol] (Dictyostelium discoideum)
        
        F-box protein [cytosol] (Dictyostelium discoideum)
        
        FBXW4 [cytosol] (Dictyostelium discoideum)
        
        E3:Ub:substrate [cytosol] (Dictyostelium discoideum)
        
        E3 ligases in proteasomal degradation [cytosol] (Dictyostelium discoideum)
        
        SCF E3 ubiquitin ligase [cytosol] (Dictyostelium discoideum)
        
        F-box protein [cytosol] (Dictyostelium discoideum)
        
        FBXW4 [cytosol] (Dictyostelium discoideum)

Metabolism of proteins (Dictyostelium discoideum)

- Post-translational protein modification (Dictyostelium discoideum)
  - Neddylation (Dictyostelium discoideum)
    - AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Dictyostelium discoideum)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Dictyostelium discoideum)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Dictyostelium discoideum)
        
        SCF E3 ubiquitin ligase [cytosol] (Dictyostelium discoideum)
        
        F-box protein [cytosol] (Dictyostelium discoideum)
        
        FBXW4 [cytosol] (Dictyostelium discoideum)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Dictyostelium discoideum)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Dictyostelium discoideum)
        
        SCF E3 ubiquitin ligase [cytosol] (Dictyostelium discoideum)
        
        F-box protein [cytosol] (Dictyostelium discoideum)
        
        FBXW4 [cytosol] (Dictyostelium discoideum)
      - NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Dictyostelium discoideum)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Dictyostelium discoideum)
        
        F-box protein [cytosol] (Dictyostelium discoideum)
        
        FBXW4 [cytosol] (Dictyostelium discoideum)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Dictyostelium discoideum)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Dictyostelium discoideum)
        
        CRL E3 ubiquitin ligases [cytosol] (Dictyostelium discoideum)
        
        SCF E3 ubiquitin ligase [cytosol] (Dictyostelium discoideum)
        
        F-box protein [cytosol] (Dictyostelium discoideum)
        
        FBXW4 [cytosol] (Dictyostelium discoideum)
      - CRL E3 ubiquitin ligases [cytosol] (Dictyostelium discoideum)
        
        SCF E3 ubiquitin ligase [cytosol] (Dictyostelium discoideum)
        
        F-box protein [cytosol] (Dictyostelium discoideum)
        
        FBXW4 [cytosol] (Dictyostelium discoideum)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Dictyostelium discoideum)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Dictyostelium discoideum)
        
        CRL E3 ubiquitin ligases [cytosol] (Dictyostelium discoideum)
        
        SCF E3 ubiquitin ligase [cytosol] (Dictyostelium discoideum)
        
        F-box protein [cytosol] (Dictyostelium discoideum)
        
        FBXW4 [cytosol] (Dictyostelium discoideum)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Dictyostelium discoideum)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Dictyostelium discoideum)
        
        SCF E3 ubiquitin ligase [cytosol] (Dictyostelium discoideum)
        
        F-box protein [cytosol] (Dictyostelium discoideum)
        
        FBXW4 [cytosol] (Dictyostelium discoideum)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Dictyostelium discoideum)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Dictyostelium discoideum)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Dictyostelium discoideum)
        
        SCF E3 ubiquitin ligase [cytosol] (Dictyostelium discoideum)
        
        F-box protein [cytosol] (Dictyostelium discoideum)
        
        FBXW4 [cytosol] (Dictyostelium discoideum)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Dictyostelium discoideum)
        
        NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Dictyostelium discoideum)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Dictyostelium discoideum)
        
        F-box protein [cytosol] (Dictyostelium discoideum)
        
        FBXW4 [cytosol] (Dictyostelium discoideum)
    - MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Dictyostelium discoideum)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Dictyostelium discoideum)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Dictyostelium discoideum)
        
        SCF E3 ubiquitin ligase [cytosol] (Dictyostelium discoideum)
        
        F-box protein [cytosol] (Dictyostelium discoideum)
        
        FBXW4 [cytosol] (Dictyostelium discoideum)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Dictyostelium discoideum)
        
        SCF E3 ubiquitin ligase [cytosol] (Dictyostelium discoideum)
        
        F-box protein [cytosol] (Dictyostelium discoideum)
        
        FBXW4 [cytosol] (Dictyostelium discoideum)
    - NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Dictyostelium discoideum)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Dictyostelium discoideum)
        
        SCF E3 ubiquitin ligase [cytosol] (Dictyostelium discoideum)
        
        F-box protein [cytosol] (Dictyostelium discoideum)
        
        FBXW4 [cytosol] (Dictyostelium discoideum)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Dictyostelium discoideum)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Dictyostelium discoideum)
        
        SCF E3 ubiquitin ligase [cytosol] (Dictyostelium discoideum)
        
        F-box protein [cytosol] (Dictyostelium discoideum)
        
        FBXW4 [cytosol] (Dictyostelium discoideum)

External Reference Information

External Reference

UniProt:Q54UQ3

Reference Genes

BioGPS Gene:8622772

dictyBase:DDB_G0280895

ENSEMBL:DDB_G0280895

KEGG Gene (Dictyostelium discoideum):DDB_G0280895

Monarch:8622772

NCBI Gene:8622772

Reference Transcript

RefSeq:XM_635876.2

Participates

as a member of

F-box protein [cytosol] (Dictyostelium discoideum)

Inferred From

FBXW4 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_640968.2

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