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usp7 [nucleoplasm]
Stable Identifier
R-DDI-3215278
Type
Protein [EntityWithAccessionedSequence]
Species
Dictyostelium discoideum
Compartment
nucleoplasm
Synonyms
USP7, Q869U4
Locations in the PathwayBrowser
Expand all
DNA Repair (Dictyostelium discoideum)
Nucleotide Excision Repair (Dictyostelium discoideum)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Dictyostelium discoideum)
Dual incision in TC-NER (Dictyostelium discoideum)
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Dictyostelium discoideum)
TC-NER incision complex [nucleoplasm] (Dictyostelium discoideum)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Dictyostelium discoideum)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Dictyostelium discoideum)
UVSSA:USP7 [nucleoplasm] (Dictyostelium discoideum)
usp7 [nucleoplasm] (Dictyostelium discoideum)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Dictyostelium discoideum)
UVSSA:USP7 [nucleoplasm] (Dictyostelium discoideum)
usp7 [nucleoplasm] (Dictyostelium discoideum)
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Dictyostelium discoideum)
TC-NER incision complex [nucleoplasm] (Dictyostelium discoideum)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Dictyostelium discoideum)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Dictyostelium discoideum)
UVSSA:USP7 [nucleoplasm] (Dictyostelium discoideum)
usp7 [nucleoplasm] (Dictyostelium discoideum)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Dictyostelium discoideum)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Dictyostelium discoideum)
UVSSA:USP7 [nucleoplasm] (Dictyostelium discoideum)
usp7 [nucleoplasm] (Dictyostelium discoideum)
DNA polymerases delta, epsilon or kappa bind the TC-NER site (Dictyostelium discoideum)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Dictyostelium discoideum)
UVSSA:USP7 [nucleoplasm] (Dictyostelium discoideum)
usp7 [nucleoplasm] (Dictyostelium discoideum)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Dictyostelium discoideum)
UVSSA:USP7 [nucleoplasm] (Dictyostelium discoideum)
usp7 [nucleoplasm] (Dictyostelium discoideum)
ERCC2-facilitated RNA Pol II backtracking in TC-NER (Dictyostelium discoideum)
TC-NER pre-incision complex [nucleoplasm] (Dictyostelium discoideum)
UVSSA:USP7 [nucleoplasm] (Dictyostelium discoideum)
usp7 [nucleoplasm] (Dictyostelium discoideum)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Dictyostelium discoideum)
UVSSA:USP7 [nucleoplasm] (Dictyostelium discoideum)
usp7 [nucleoplasm] (Dictyostelium discoideum)
ERCC3-facilitated RNA Pol II backtracking in TC-NER (Dictyostelium discoideum)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Dictyostelium discoideum)
UVSSA:USP7 [nucleoplasm] (Dictyostelium discoideum)
usp7 [nucleoplasm] (Dictyostelium discoideum)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Dictyostelium discoideum)
UVSSA:USP7 [nucleoplasm] (Dictyostelium discoideum)
usp7 [nucleoplasm] (Dictyostelium discoideum)
Formation of TC-NER Pre-Incision Complex (Dictyostelium discoideum)
UVSSA:USP7 deubiquitinates ERCC6 (Dictyostelium discoideum)
TC-NER pre-incision complex [nucleoplasm] (Dictyostelium discoideum)
UVSSA:USP7 [nucleoplasm] (Dictyostelium discoideum)
usp7 [nucleoplasm] (Dictyostelium discoideum)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Dictyostelium discoideum)
UVSSA:USP7 [nucleoplasm] (Dictyostelium discoideum)
usp7 [nucleoplasm] (Dictyostelium discoideum)
Gap-filling DNA repair synthesis and ligation in TC-NER (Dictyostelium discoideum)
Ligation of newly synthesized repair patch to incised DNA in TC-NER (Dictyostelium discoideum)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Dictyostelium discoideum)
UVSSA:USP7 [nucleoplasm] (Dictyostelium discoideum)
usp7 [nucleoplasm] (Dictyostelium discoideum)
TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Dictyostelium discoideum)
UVSSA:USP7 [nucleoplasm] (Dictyostelium discoideum)
usp7 [nucleoplasm] (Dictyostelium discoideum)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Dictyostelium discoideum)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Dictyostelium discoideum)
UVSSA:USP7 [nucleoplasm] (Dictyostelium discoideum)
usp7 [nucleoplasm] (Dictyostelium discoideum)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Dictyostelium discoideum)
UVSSA:USP7 [nucleoplasm] (Dictyostelium discoideum)
usp7 [nucleoplasm] (Dictyostelium discoideum)
Metabolism of proteins (Dictyostelium discoideum)
Post-translational protein modification (Dictyostelium discoideum)
Deubiquitination (Dictyostelium discoideum)
Ub-specific processing proteases (Dictyostelium discoideum)
USP7 deubiquitinates TP53,MDM2,MDM4,FOXO4, PTEN (Dictyostelium discoideum)
USP7:PolyUb-TP53,PolyUb-MDM2,PolyUb-MDM4,PolyUb-FOXO4,PolyUb-PTEN [nucleoplasm] (Dictyostelium discoideum)
usp7 [nucleoplasm] (Dictyostelium discoideum)
USP7:TP53,MDM2,MDM4,FOXO4,PTEN [nucleoplasm] (Dictyostelium discoideum)
usp7 [nucleoplasm] (Dictyostelium discoideum)
usp7 [nucleoplasm] (Dictyostelium discoideum)
Signal Transduction (Dictyostelium discoideum)
Intracellular signaling by second messengers (Dictyostelium discoideum)
PIP3 activates AKT signaling (Dictyostelium discoideum)
PTEN Regulation (Dictyostelium discoideum)
Regulation of PTEN localization (Dictyostelium discoideum)
USP7 deubiquitinates monoubiquitinated PTEN (Dictyostelium discoideum)
usp7 [nucleoplasm] (Dictyostelium discoideum)
External Reference Information
External Reference
UniProt:Q869U4
Gene Names
usp7
Reference Genes
BioGPS Gene:8620554 usp7
dictyBase:DDB_G0276443
ENSEMBL:DDB_G0276443
KEGG:ddi:DDB_G0276443 usp7
Monarch:8620554 usp7
NCBI Gene:8620554 usp7
UCSC:Q869U4 usp7
Reference Transcript
RefSeq:XM_638055.1 usp7
Participates
as a component of
USP7:TP53,MDM2,MDM4,FOXO4,PTEN [nucleoplasm] (Dictyostelium discoideum)
USP7:PolyUb-TP53,PolyUb-MDM2,PolyUb-MDM4,PolyUb-FOXO4,PolyUb-PTEN [nucleoplasm] (Dictyostelium discoideum)
UVSSA:USP7 [nucleoplasm] (Dictyostelium discoideum)
Other forms of this molecule
usp7 [cytosol]
usp7 [cytosol]
Inferred From
USP7 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
XP_643147.1
PRO
Q869U4
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