Reactome | DUSP4 [nucleoplasm]

DUSP4 [nucleoplasm]

Stable Identifier

R-DDI-203794-3

Type

Protein [EntityWithAccessionedSequence]

Species

Dictyostelium discoideum

Compartment

nucleoplasm

Synonyms

Q556Y8

Locations in the PathwayBrowser

Expand all

Immune System (Dictyostelium discoideum)

- Cytokine Signaling in Immune system (Dictyostelium discoideum)
  - Signaling by Interleukins (Dictyostelium discoideum)
    - Interleukin-17 signaling (Dictyostelium discoideum)
      - MAP kinase activation (Dictyostelium discoideum)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Dictyostelium discoideum)
        
        ERK/MAPK targets (Dictyostelium discoideum)
        
        ERKs are inactivated (Dictyostelium discoideum)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Dictyostelium discoideum)
        
        ERK-specific DUSP [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of DUSP4 [nucleoplasm] (Dictyostelium discoideum)
        
        DUSP4 [nucleoplasm] (Dictyostelium discoideum)
- Innate Immune System (Dictyostelium discoideum)
  - Toll-like Receptor Cascades (Dictyostelium discoideum)
    - Toll Like Receptor 10 (TLR10) Cascade (Dictyostelium discoideum)
      - MyD88 cascade initiated on plasma membrane (Dictyostelium discoideum)
        
        MAP kinase activation (Dictyostelium discoideum)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Dictyostelium discoideum)
        
        ERK/MAPK targets (Dictyostelium discoideum)
        
        ERKs are inactivated (Dictyostelium discoideum)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Dictyostelium discoideum)
        
        ERK-specific DUSP [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of DUSP4 [nucleoplasm] (Dictyostelium discoideum)
        
        DUSP4 [nucleoplasm] (Dictyostelium discoideum)
    - Toll Like Receptor 2 (TLR2) Cascade (Dictyostelium discoideum)
      - Toll Like Receptor TLR1:TLR2 Cascade (Dictyostelium discoideum)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Dictyostelium discoideum)
        
        MAP kinase activation (Dictyostelium discoideum)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Dictyostelium discoideum)
        
        ERK/MAPK targets (Dictyostelium discoideum)
        
        ERKs are inactivated (Dictyostelium discoideum)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Dictyostelium discoideum)
        
        ERK-specific DUSP [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of DUSP4 [nucleoplasm] (Dictyostelium discoideum)
        
        DUSP4 [nucleoplasm] (Dictyostelium discoideum)
      - Toll Like Receptor TLR6:TLR2 Cascade (Dictyostelium discoideum)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Dictyostelium discoideum)
        
        MAP kinase activation (Dictyostelium discoideum)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Dictyostelium discoideum)
        
        ERK/MAPK targets (Dictyostelium discoideum)
        
        ERKs are inactivated (Dictyostelium discoideum)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Dictyostelium discoideum)
        
        ERK-specific DUSP [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of DUSP4 [nucleoplasm] (Dictyostelium discoideum)
        
        DUSP4 [nucleoplasm] (Dictyostelium discoideum)
    - Toll Like Receptor 3 (TLR3) Cascade (Dictyostelium discoideum)
      - MAP kinase activation (Dictyostelium discoideum)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Dictyostelium discoideum)
        
        ERK/MAPK targets (Dictyostelium discoideum)
        
        ERKs are inactivated (Dictyostelium discoideum)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Dictyostelium discoideum)
        
        ERK-specific DUSP [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of DUSP4 [nucleoplasm] (Dictyostelium discoideum)
        
        DUSP4 [nucleoplasm] (Dictyostelium discoideum)
    - Toll Like Receptor 4 (TLR4) Cascade (Dictyostelium discoideum)
      - MyD88-independent TLR4 cascade (Dictyostelium discoideum)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Dictyostelium discoideum)
        
        MAP kinase activation (Dictyostelium discoideum)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Dictyostelium discoideum)
        
        ERK/MAPK targets (Dictyostelium discoideum)
        
        ERKs are inactivated (Dictyostelium discoideum)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Dictyostelium discoideum)
        
        ERK-specific DUSP [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of DUSP4 [nucleoplasm] (Dictyostelium discoideum)
        
        DUSP4 [nucleoplasm] (Dictyostelium discoideum)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Dictyostelium discoideum)
        
        MAP kinase activation (Dictyostelium discoideum)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Dictyostelium discoideum)
        
        ERK/MAPK targets (Dictyostelium discoideum)
        
        ERKs are inactivated (Dictyostelium discoideum)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Dictyostelium discoideum)
        
        ERK-specific DUSP [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of DUSP4 [nucleoplasm] (Dictyostelium discoideum)
        
        DUSP4 [nucleoplasm] (Dictyostelium discoideum)
    - Toll Like Receptor 5 (TLR5) Cascade (Dictyostelium discoideum)
      - MyD88 cascade initiated on plasma membrane (Dictyostelium discoideum)
        
        MAP kinase activation (Dictyostelium discoideum)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Dictyostelium discoideum)
        
        ERK/MAPK targets (Dictyostelium discoideum)
        
        ERKs are inactivated (Dictyostelium discoideum)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Dictyostelium discoideum)
        
        ERK-specific DUSP [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of DUSP4 [nucleoplasm] (Dictyostelium discoideum)
        
        DUSP4 [nucleoplasm] (Dictyostelium discoideum)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Dictyostelium discoideum)
      - MyD88 dependent cascade initiated on endosome (Dictyostelium discoideum)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Dictyostelium discoideum)
        
        MAP kinase activation (Dictyostelium discoideum)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Dictyostelium discoideum)
        
        ERK/MAPK targets (Dictyostelium discoideum)
        
        ERKs are inactivated (Dictyostelium discoideum)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Dictyostelium discoideum)
        
        ERK-specific DUSP [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of DUSP4 [nucleoplasm] (Dictyostelium discoideum)
        
        DUSP4 [nucleoplasm] (Dictyostelium discoideum)
    - Toll Like Receptor 9 (TLR9) Cascade (Dictyostelium discoideum)
      - MyD88 dependent cascade initiated on endosome (Dictyostelium discoideum)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Dictyostelium discoideum)
        
        MAP kinase activation (Dictyostelium discoideum)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Dictyostelium discoideum)
        
        ERK/MAPK targets (Dictyostelium discoideum)
        
        ERKs are inactivated (Dictyostelium discoideum)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Dictyostelium discoideum)
        
        ERK-specific DUSP [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of DUSP4 [nucleoplasm] (Dictyostelium discoideum)
        
        DUSP4 [nucleoplasm] (Dictyostelium discoideum)

Signal Transduction (Dictyostelium discoideum)

- MAPK family signaling cascades (Dictyostelium discoideum)
  - MAPK1/MAPK3 signaling (Dictyostelium discoideum)
    - RAF-independent MAPK1/3 activation (Dictyostelium discoideum)
      - Nuclear DUSPs dephosphorylate MAPKs (Dictyostelium discoideum)
        
        nuclear MAPK DUSPs [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of DUSP4 [nucleoplasm] (Dictyostelium discoideum)
        
        DUSP4 [nucleoplasm] (Dictyostelium discoideum)
    - RAF/MAP kinase cascade (Dictyostelium discoideum)
      - Negative regulation of MAPK pathway (Dictyostelium discoideum)
        
        Nuclear DUSPs dephosphorylate MAPKs (Dictyostelium discoideum)
        
        nuclear MAPK DUSPs [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of DUSP4 [nucleoplasm] (Dictyostelium discoideum)
        
        DUSP4 [nucleoplasm] (Dictyostelium discoideum)
- Signaling by Receptor Tyrosine Kinases (Dictyostelium discoideum)
  - Signaling by NTRKs (Dictyostelium discoideum)
    - Signaling by NTRK1 (TRKA) (Dictyostelium discoideum)
      - Nuclear Events (kinase and transcription factor activation) (Dictyostelium discoideum)
        
        ERK/MAPK targets (Dictyostelium discoideum)
        
        ERKs are inactivated (Dictyostelium discoideum)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Dictyostelium discoideum)
        
        ERK-specific DUSP [nucleoplasm] (Dictyostelium discoideum)
        
        Homologues of DUSP4 [nucleoplasm] (Dictyostelium discoideum)
        
        DUSP4 [nucleoplasm] (Dictyostelium discoideum)

External Reference Information

External Reference

UniProt:Q556Y8

Reference Genes

BioGPS Gene:8618871

BioGPS Gene:8619105

dictyBase:DDB_G0273199

ENSEMBL:DDB_G0273199

KEGG Gene (Dictyostelium discoideum):DDB_G0273199

KEGG Gene (Dictyostelium discoideum):DDB_G0273729

Monarch:8618871

Monarch:8619105

NCBI Gene:8618871

NCBI Gene:8619105

Reference Transcript

Participates

as a member of

Homologues of DUSP4 [nucleoplasm] (Dictyostelium discoideum)

Other forms of this molecule

DUSP5 [nucleoplasm]

DUSP16 [nucleoplasm]

DUSP2 [nucleoplasm]

DUSP1 [nucleoplasm]

DUSP8 [nucleoplasm]

DUSP10 [nucleoplasm]

DUSP7 [cytosol]

DUSP9 [cytosol]

DUSP16 [cytosol]

DUSP8 [cytosol]

DUSP10 [cytosol]

DUSP7 [nucleoplasm]

Inferred From

DUSP4 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

XP_644481.1, XP_644769.1

PRO

Q556Y8

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