high-mannose N-glycan folded Spike [endoplasmic reticulum lumen]

Stable Identifier
R-COV-9696880
Type
Protein [EntityWithAccessionedSequence]
Species
Severe acute respiratory syndrome coronavirus 2
Compartment
endoplasmic reticulum lumen
Locations in the PathwayBrowser for interactor UniProt:P0DTC2
Expand all
Literature References
PubMed ID Title Journal Year
32366695 Site-specific glycan analysis of the SARS-CoV-2 spike

Watanabe, Y, Allen, JD, Wrapp, D, McLellan, JS, Crispin, M

Science 2020
External Reference Information
External Reference
UniProt:P0DTC2 S
Gene Names
S, 2
Chain
signal peptide:1-12, chain:13-1273, chain:13-685, chain:686-1273, chain:816-1273
Reference Genes
BioGPS Gene:43740568 S
KEGG Gene (Hepatitis C Virus):43740568 S
Monarch:43740568 S
NCBI Gene:43740568 S
Reference Transcript
Participates
as an output of
as an input of
Other forms of this molecule
fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment]
tri-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
nascent Spike [endoplasmic reticulum lumen]
14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen]
Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen]
high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen]
high-mannose N-glycan-PALM-Spike [endoplasmic reticulum lumen]
complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane]
complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane]
complex N-glycan-PALM-Spike S1 Fragment [virion membrane]
complex N-glycan-PALM-Spike S2 Fragment [virion membrane]
fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane]
fully glycosylated Spike [virion membrane]
Modified Residues
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 1074
Coordinate
1074
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 1098
Coordinate
1098
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 1134
Coordinate
1134
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 1158
Coordinate
1158
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 1173
Coordinate
1173
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 1194
Coordinate
1194
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 122
Coordinate
122
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 149
Coordinate
149
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 165
Coordinate
165
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 17
Coordinate
17
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 282
Coordinate
282
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 331
Coordinate
331
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 343
Coordinate
343
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 603
Coordinate
603
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 61
Coordinate
61
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 616
Coordinate
616
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 657
Coordinate
657
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 709
Coordinate
709
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 717
Coordinate
717
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 74
Coordinate
74
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 801
Coordinate
801
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (Man(9) N-glycan group) at 234
Coordinate
234
Modification
Man(9) N-glycan group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Cross References
RefSeq
PDB
7BYR, 6Z97, 6Z2M, 7BWJ, 7JMP, 6YOR, 7C8D, 6LVN, 7KDG, 6XRA, 6XC4, 7CHF, 6X6P, 7JVA, 7K8W, 6XM5, 6ZGG, 7C8W, 7KDL, 7A5S, 6VW1, 6VXX, 7JZN, 7KE9, 6ZOX, 7A91, 6ZDH, 7JWB, 7K43, 6ZP7, 6XKP, 6XEY, 6XR8, 7JV2, 7CHB, 6ZBP, 7JX3, 7A97, 6LZG, 6X2A, 6X2C, 6XDG, 7JV4, 7CHC, 7KDH, 6XC2, 7C2L, 7JMW, 6XC7, 7JJI, 7KDJ, 6LXT, 7JVC, 6ZB4, 7JZL, 7A29, 6XM3, 7K8U, 7K8Z, 6ZP0, 6ZCZ, 6ZER, 6YM0, 7KE4, 7CAH, 6ZWV, 7CH4, 7CAK, 6XCN, 6ZP2, 7KE7, 6XKQ, 7K45, 6M0J, 6VSB, 7A4N, 7A94, 6X29, 7KEC, 6ZHD, 6ZXN, 7CHE, 7JV6, 7A95, 6XC3, 7CHH, 7BZ5, 7KDK, 7K8S, 7A5R, 7C8V, 7K4N, 6ZGI, 6X79, 6XS6, 7K90, 6M1V, 6XLU, 6XM4, 7JJJ, 6ZOW, 6Z43, 7K8X, 6ZOY, 6XKL, 7CAN, 7JZU, 6ZP5, 6W41, 7KEA, 6VYB, 7C01, 6XF5, 6WPS, 6YZ5, 6ZFO, 6M17, 7CN9, 7A92, 6YZ7, 6X2B, 7A96, 7JJC, 7A98, 7K9Z, 6XM0, 7K8T, 6ZGE, 6XE1, 7AD1, 6YLA, 7KDI, 7K8V, 6ZB5, 7CAI, 7KE6, 7K8Y, 7JW0, 7JZM, 6ZH9, 6XCM, 6ZOZ, 6ZP1, 7KE8, 6ZDG, 6WPT, 7CH5, 7JMO, 6XF6, 7KEB, 7A93
Interactors (18)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q9BYF1 ACE2  5 0.992 103
 UniProt:P0DTC2 S  16 0.951 15
 UniProt:P09958 FURIN  4 0.801 4
 UniProt:Q9NNX6 CD209  1 0.766 6
 UniProt:Q9H2X3 CLC4M      0.71 5
 UniProt:Q96D42 HAVR1      0.667 7
 UniProt:Q7Z5G4 GOLGA7  3 0.643 3
 UniProt:Q9C0B5 ZDHC5      0.643 3
 UniProt:O14786 NRP1  1 0.639 9
 UniProt:Q8IUN9 CLEC10A  1 0.623 4
 ChEBI:28304 HEPARIN      0.623 5
 UniProt:Q96LC7 SIGLEC10  1 0.623 2
 UniProt:P35613 BSG  2 0.618 5
 cholesterol [ChEBI:16113]  20 0.558 5
 lipopolysaccharide [ChEBI:16412]  5 0.558 3
 UniProt:Q8IUN9-2 CLEC10A      0.558 3
 UniProt:Q61830 Mrc1  4 0.558 2
 linoleic acid [ChEBI:17351]  6 0.522 2
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