Reactome | O-glycosyl 3a [endoplasmic reticulum-Golgi intermediate compartment membrane]

O-glycosyl 3a [endoplasmic reticulum-Golgi intermediate compartment membrane]

Stable Identifier

R-COV-9694386

Type

Protein [EntityWithAccessionedSequence]

Species

Severe acute respiratory syndrome coronavirus 2

Compartment

endoplasmic reticulum-Golgi intermediate compartment membrane

Synonyms

P0DTC3

Locations in the PathwayBrowser for interactor UniProt:Q96GS4 BORC6

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General

SARS-CoV-2 mRNA2 open reading frame has a length of 3,822 nt and encodes the 1,273 aa spike preprotein (Wu et al, 2020).

Literature References

PubMed ID	Title	Journal	Year
16474139	Glycosylation of the severe acute respiratory syndrome coronavirus triple-spanning membrane proteins 3a and M de Haan, CA, de Groot, RJ, Oostra, M, Rottier, PJ	J. Virol.	2006

External Reference Information

External Reference

UniProt:P0DTC3 3a

Gene Names

Chain

chain:1-275

Participates

as an output of

O-glycosylation of 3a is terminated (Homo sapiens)

as an input of

Protein 3a forms a homotetramer (Homo sapiens)

as a component of

O-glycosyl 3a tetramer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Severe acute respiratory syndrome coronavirus 2)

Other forms of this molecule

O-glycosyl 3a [virion membrane]

O-glycosyl 3a [endocytic vesicle membrane]

GalNAc-O-3a [endoplasmic reticulum-Golgi intermediate compartment]

3a [endoplasmic reticulum-Golgi intermediate compartment]

3a [endoplasmic reticulum lumen]

O-glycosyl 3a [endolysosome membrane]

O-glycosyl 3a [plasma membrane]

O-glycosyl 3a [extracellular region]

Inferred From

O-glycosyl 3a [endoplasmic reticulum-Golgi intermediate compartment membrane] (Human SARS coronavirus)

Modified Residues

Name

O-glycosyl-L-threonine at unknown position

PsiMod Name

O-glycosyl-L-threonine

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O3-glycosylthreonine.

Disease

Name	Identifier	Synonyms
COVID-19	DOID:0080600	2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection

Cross References

PDB

8EQJ, 7KJR, 8EQT, 8T5P, 8EQU, 6XDC, 8T5Q

Interactors (44)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96JC1 VPS39	1	VPS39 [endosome membrane] (R-HSA-2197806)	0.956	19
UniProt:Q96S66 CLCC1			0.875	9
UniProt:Q9H270 VPS11	1	VPS11 [endosome membrane] (R-HSA-2197802)	0.823	7
UniProt:Q9Y673 ALG5	1	ALG5 [endoplasmic reticulum membrane] (R-HSA-532211)	0.738	4
UniProt:P09601 HMOX1	4	HMOX1 [nucleoplasm] (R-HSA-9708567) HMOX1 [mitochondrial outer membrane] (R-HSA-9708524) HMOX1 [endoplasmic reticulum membrane] (R-HSA-189395) HMOX1 [cytosol] (R-HSA-9609901)	0.738	4
UniProt:P0DTC3 3a	9	O-glycosyl 3a [virion membrane] (R-COV-9694395) O-glycosyl 3a [endocytic vesicle membrane] (R-COV-9694729) O-glycosyl 3a [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694386) GalNAc-O-3a [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9694658) 3a [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9694716) 3a [endoplasmic reticulum lumen] (R-COV-9694584) O-glycosyl 3a [endolysosome membrane] (R-COV-9754541) O-glycosyl 3a [plasma membrane] (R-COV-9694433) O-glycosyl 3a [extracellular region] (R-COV-9694387)	0.716	4
UniProt:P49754 VPS41	1	VPS41 [endosome membrane] (R-HSA-2197800)	0.695	4
UniProt:Q9UH99 SUN2	1	SUN2 [nuclear envelope] (R-HSA-912382)	0.659	3
UniProt:Q8NBJ7 SUMF2	1	SUMF2 [endoplasmic reticulum lumen] (R-HSA-1614305)	0.659	3
UniProt:Q8N6S5 AR6P6			0.643	3
UniProt:Q8IWR1 TRI59			0.643	3
UniProt:Q01518 CAP1	3	CAP1 [cytosol] (R-HSA-350758) CAP1 [extracellular region] (R-HSA-350746) CAP1 [azurophil granule lumen] (R-HSA-6798752)	0.613	3
UniProt:P51809 VAMP7	6	VAMP7 [late endosome membrane] (R-HSA-2193120) VAMP7 [lysosomal membrane] (R-HSA-376342) VAMP7 [plasma membrane] (R-HSA-376361) VAMP7 [Golgi membrane] (R-HSA-266197) VAMP7 [cytoplasmic vesicle membrane] (R-HSA-376336) VAMP7 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869135)	0.602	4
UniProt:Q9P2Y5 UVRAG	2	UVRAG [cytosol] (R-HSA-5668884) UVRAG [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9730510)	0.602	6
UniProt:Q12846 STX4	4	STX4 [phagocytic vesicle membrane] (R-HSA-2029044) STX4 [plasma membrane] (R-HSA-181519) STX4 [cytosol] (R-HSA-114505) p-STX4 [cytosol] (R-HSA-114681)	0.602	4
UniProt:Q8NBS9 TXNDC5	4	TXNDC5 [Golgi lumen] (R-HSA-434325) TXNDC5 [lysosomal lumen] (R-HSA-429813) TXNDC5 [extracellular region] (R-HSA-6806246) TXNDC5 [azurophil granule lumen] (R-HSA-6799367)	0.547	2
UniProt:Q96HE7 ERO1A	1	ERO1L [endoplasmic reticulum lumen] (R-HSA-265076)	0.547	2
UniProt:P07205 PGK2	1	PGK2 [cytosol] (R-HSA-6807622)	0.547	2
UniProt:P50454 SERPINH1	1	SERPINH1 [endoplasmic reticulum lumen] (R-HSA-2127480)	0.547	2
UniProt:P35609 ACTN2	3	ACTN2 [cytosol] (R-HSA-390562) ACTN2 [platelet alpha granule lumen] (R-HSA-349727) ACTN2 [extracellular region] (R-HSA-349725)	0.547	2
UniProt:Q92545 TM131			0.547	2
UniProt:Q9H0V9 LMAN2L	3	LMAN2L [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5689834) LMAN2L [ER to Golgi transport vesicle membrane] (R-HSA-5689832) LMAN2L [endoplasmic reticulum membrane] (R-HSA-5689469)	0.547	2
UniProt:P16422 EPCAM	1	EPCAM [plasma membrane] (R-HSA-375068)	0.527	2
UniProt:O75976 CPD	3	CPD [Golgi membrane] (R-HSA-432675) CPD [cytoplasmic vesicle membrane] (R-HSA-432671) CPD [plasma membrane] (R-HSA-9715182)	0.527	2
UniProt:P04439 HLA-A	9	K48polyUb-HLA-A A-2 [endoplasmic reticulum membrane] (R-HSA-8943073) HLA-A A-3 [endoplasmic reticulum membrane] (R-HSA-8943090) HLA class I histocompatibility antigen, A-3 alpha chain precursor [phagocytic vesicle membrane] (R-HSA-1236740) HLA class I histocompatibility antigen, A-3 alpha chain precursor [recycling endosome membrane] (R-HSA-8863889) HLA class I histocompatibility antigen, A-3 alpha chain precursor [early endosome membrane] (R-HSA-1236826) HLA class I histocompatibility antigen, A-3 alpha chain precursor [plasma membrane] (R-HSA-197642) HLA class I histocompatibility antigen, A-3 alpha chain precursor [Golgi membrane] (R-HSA-983376) HLA class I histocompatibility antigen, A-3 alpha chain precursor [ER to Golgi transport vesicle membrane] (R-HSA-983347) HLA class I histocompatibility antigen, A-3 alpha chain precursor [lumenal side of endoplasmic reticulum membrane] (R-HSA-983100)	0.527	2
UniProt:P30519 HMOX2	3	HMOX2 [plasma membrane] (R-HSA-6799676) HMOX2 [specific granule membrane] (R-HSA-6799628) HMOX2 [endoplasmic reticulum membrane] (R-HSA-189391)	0.527	2
UniProt:Q9UNN8 PROCR	2	PROCR(18-?) [extracellular region] (R-HSA-5610109) PROCR [plasma membrane] (R-HSA-5591027)	0.527	2
UniProt:P61106 RAB14	7	GGC-RAB14 [cytoplasmic vesicle membrane] (R-HSA-1445086) GGC-RAB14 [recycling endosome membrane] (R-HSA-8876593) GGC-RAB14 [cytosol] (R-HSA-8873763) RAB14 [cytosol] (R-HSA-8873701) RAB14 [early endosome membrane] (R-HSA-8871372) RAB14 [plasma membrane] (R-HSA-6806438) RAB14 [tertiary granule membrane] (R-HSA-6800407)	0.527	2
UniProt:Q9Y617 PSAT1	1	PXLP-K200-PSAT1 [cytosol] (R-HSA-977330)	0.527	2
UniProt:Q9NRX4 PHP14			0.527	2
UniProt:P51153 RAB13	4	GGC-RAB13 [cytoplasmic vesicle membrane] (R-HSA-1445110) GGC-RAB13 [cell junction] (R-HSA-8876591) GGC-RAB13 [cytosol] (R-HSA-8873767) RAB13 [cytosol] (R-HSA-8873674)	0.527	2
UniProt:Q15005 SPCS2	1	SPCS2 [endoplasmic reticulum membrane] (R-HSA-264996)	0.527	2
UniProt:Q9Y4P3 TBL2			0.527	2
UniProt:P0DTD8 NS7B			0.519	3
UniProt:Q8NAF0 ZN579			0.499	2
UniProt:P0DTD1-PRO_0000449632 REP			0.488	2
UniProt:Q9P253 VPS18	1	VPS18 [endosome membrane] (R-HSA-2197799)	0.483	2
UniProt:Q8NHV4 NEDD1	1	NEDD1 [cytosol] (R-HSA-379267)	0.483	2
UniProt:Q9H269 VPS16	1	VPS16 [endosome membrane] (R-HSA-2197803)	0.483	2
UniProt:Q12913 PTPRJ	2	PTPRJ [plasma membrane] (R-HSA-6785269) PTPRJ [specific granule membrane] (R-HSA-6799570)	0.483	2
UniProt:P42765 ACAA2	1	ACAA2 [mitochondrial matrix] (R-HSA-8874752)	0.482	2
UniProt:Q9H3K2 GHITM			0.482	2
UniProt:Q96GS4 BORC6			0.463	2
UniProt:Q9GZU1 MCOLN1	2	MCOLN1 [plasma membrane] (R-HSA-3211764) MCOLN1 [endosome membrane] (R-HSA-917803)	0.463	2

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