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ITCH [cytosol]
Stable Identifier
R-CFA-975995
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
ITCH, A0A8I3NYH6
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Class I MHC mediated antigen processing & presentation (Canis familiaris)
Antigen processing: Ubiquitination & Proteasome degradation (Canis familiaris)
Interaction of E3 with substrate and E2-Ub complex (Canis familiaris)
Ag-substrate:E3:E2:Ub [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
ITCH [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
ITCH [cytosol] (Canis familiaris)
Polyubiquitination of substrate (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
ITCH [cytosol] (Canis familiaris)
E3:K48-polyubiquitinated substrate [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
ITCH [cytosol] (Canis familiaris)
E3:Ub:substrate [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
ITCH [cytosol] (Canis familiaris)
Release of E3 from polyubiquitinated substrate (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
ITCH [cytosol] (Canis familiaris)
E3:K48-polyubiquitinated substrate [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
ITCH [cytosol] (Canis familiaris)
Transfer of Ub from E2 to substrate and release of E2 (Canis familiaris)
Ag-substrate:E3:E2:Ub [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
ITCH [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
ITCH [cytosol] (Canis familiaris)
E3:Ub:substrate [cytosol] (Canis familiaris)
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
ITCH [cytosol] (Canis familiaris)
Innate Immune System (Canis familiaris)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Canis familiaris)
NOD1/2 Signaling Pathway (Canis familiaris)
RIP2 is K63 polyubiquitinated (Canis familiaris)
RIP2 ubiquitin ligases [cytosol] (Canis familiaris)
ITCH [cytosol] (Canis familiaris)
Signal Transduction (Canis familiaris)
Signaling by Hedgehog (Canis familiaris)
Hedgehog 'off' state (Canis familiaris)
Degradation of GLI1 by the proteasome (Canis familiaris)
GLI1 is degraded by the proteasome after ubiquitination by ITCH (Canis familiaris)
NUMB:ITCH [cytosol] (Canis familiaris)
ITCH [cytosol] (Canis familiaris)
NUMB:ITCH:ub-pS-GLI1:SUFU [cytosol] (Canis familiaris)
NUMB:ITCH [cytosol] (Canis familiaris)
ITCH [cytosol] (Canis familiaris)
NUMB binds ITCH (Canis familiaris)
ITCH [cytosol] (Canis familiaris)
NUMB:ITCH [cytosol] (Canis familiaris)
ITCH [cytosol] (Canis familiaris)
NUMB:ITCH bind and ubiquitnate GLI1 (Canis familiaris)
ITCH [cytosol] (Canis familiaris)
NUMB:ITCH [cytosol] (Canis familiaris)
ITCH [cytosol] (Canis familiaris)
NUMB:ITCH:ub-pS-GLI1:SUFU [cytosol] (Canis familiaris)
NUMB:ITCH [cytosol] (Canis familiaris)
ITCH [cytosol] (Canis familiaris)
Hedgehog 'on' state (Canis familiaris)
NUMB binds ITCH (Canis familiaris)
ITCH [cytosol] (Canis familiaris)
NUMB:ITCH [cytosol] (Canis familiaris)
ITCH [cytosol] (Canis familiaris)
NUMB:ITCH binds GLI1 (Canis familiaris)
GLI1:NUMB:ITCH [cytosol] (Canis familiaris)
NUMB:ITCH [cytosol] (Canis familiaris)
ITCH [cytosol] (Canis familiaris)
NUMB:ITCH [cytosol] (Canis familiaris)
ITCH [cytosol] (Canis familiaris)
NUMB:ITCH ubiquitinates GLI1 (Canis familiaris)
GLI1:NUMB:ITCH [cytosol] (Canis familiaris)
NUMB:ITCH [cytosol] (Canis familiaris)
ITCH [cytosol] (Canis familiaris)
ITCH [cytosol] (Canis familiaris)
ub-GLI1:NUMB:ITCH [cytosol] (Canis familiaris)
NUMB:ITCH [cytosol] (Canis familiaris)
ITCH [cytosol] (Canis familiaris)
ub-GLI is degraded by the proteasome (Canis familiaris)
NUMB:ITCH [cytosol] (Canis familiaris)
ITCH [cytosol] (Canis familiaris)
ub-GLI1:NUMB:ITCH [cytosol] (Canis familiaris)
NUMB:ITCH [cytosol] (Canis familiaris)
ITCH [cytosol] (Canis familiaris)
Signaling by NOTCH (Canis familiaris)
Signaling by NOTCH1 (Canis familiaris)
Activated NOTCH1 Transmits Signal to the Nucleus (Canis familiaris)
ITCH binds DTX (Canis familiaris)
DTX:ITCH [cytosol] (Canis familiaris)
ITCH [cytosol] (Canis familiaris)
ITCH [cytosol] (Canis familiaris)
ITCH ubiquitinates DTX (Canis familiaris)
DTX:ITCH [cytosol] (Canis familiaris)
ITCH [cytosol] (Canis familiaris)
Ub-DTX:ITCH [cytosol] (Canis familiaris)
ITCH [cytosol] (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by ERBB4 (Canis familiaris)
Downregulation of ERBB4 signaling (Canis familiaris)
ERBB4 binds WWP1/ITCH ubiquitin ligases (Canis familiaris)
ERBB4/m80/s80:WWP1/ITCH [plasma membrane] (Canis familiaris)
WWP1/ITCH [cytosol] (Canis familiaris)
ITCH [cytosol] (Canis familiaris)
WWP1/ITCH [cytosol] (Canis familiaris)
ITCH [cytosol] (Canis familiaris)
ERBB4 ubiquitination by WWP1/ITCH (Canis familiaris)
ERBB4/m80/s80:WWP1/ITCH [plasma membrane] (Canis familiaris)
WWP1/ITCH [cytosol] (Canis familiaris)
ITCH [cytosol] (Canis familiaris)
Ub-ERBB4:WWP1/ITCH [plasma membrane] (Canis familiaris)
WWP1/ITCH [cytosol] (Canis familiaris)
ITCH [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3NYH6
Gene Names
ITCH
Reference Genes
BioGPS Gene:477199 ITCH
ENSEMBL:ENSCAFG00845015881.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845015881.1 ITCH
Monarch:477199 ITCH
NCBI Gene:477199 ITCH
Reference Transcript
RefSeq:XM_846367.4 ITCH
RefSeq:XM_014107005.1 ITCH
Other Identifiers
477199
Cfa.12709.1.S1_s_at
CfaAffx.12151.1.S1_at
CfaAffx.12165.1.S1_s_at
GO:0000209
GO:0002376
GO:0002669
GO:0002870
GO:0003824
GO:0004842
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005768
GO:0005769
GO:0005886
GO:0005938
GO:0006511
GO:0006513
GO:0007155
GO:0012501
GO:0016020
GO:0016192
GO:0016567
GO:0016740
GO:0016874
GO:0023052
GO:0030163
GO:0031410
GO:0031623
GO:0032991
GO:0035519
GO:0035739
GO:0036211
GO:0043021
GO:0043066
GO:0043161
GO:0043226
GO:0043231
GO:0044389
GO:0045236
GO:0045732
GO:0046329
GO:0048856
GO:0050687
GO:0051865
GO:0061630
GO:0070534
GO:0070936
GO:0090085
GO:0098542
GO:0140096
GO:1990763
GO:2000562
GO:2000646
Participates
as a member of
WWP1/ITCH [cytosol] (Canis familiaris)
RIP2 ubiquitin ligases [cytosol] (Canis familiaris)
as an input of
NUMB binds ITCH (Canis familiaris)
ITCH binds DTX (Canis familiaris)
as a component of
NUMB:ITCH [cytosol] (Canis familiaris)
Ub-DTX:ITCH [cytosol] (Canis familiaris)
DTX:ITCH [cytosol] (Canis familiaris)
p-S-RIPK1:p-S-RIPK3:p-T,S-MLKL:ITCH:Ub:UBE2L3 [cytosol] (Canis familiaris)
as a candidate of
E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
Inferred From
ITCH [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_851460.1
,
XP_013962480.1
OpenTargets
ENSG00000078747
Ensembl
ENSCAFT00845028298
,
ENSCAFP00845022264
,
ENSCAFG00845015881
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