Reactome | NLRX1 [cytosol]

NLRX1 [cytosol]

Stable Identifier

R-CFA-9749510

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

K63polyUb-NLRX1, A0A8I3NRJ3

Locations in the PathwayBrowser

Expand all

Immune System (Canis familiaris)

- Cytokine Signaling in Immune system (Canis familiaris)
  - Signaling by Interleukins (Canis familiaris)
    - Interleukin-1 family signaling (Canis familiaris)
      - Interleukin-1 signaling (Canis familiaris)
        
        TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
        
        Regulation of NF-kappa B signaling (Canis familiaris)
        
        NLRX1 binds CHUK:IKBKB:IKBKG (Canis familiaris)
        
        CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Canis familiaris)
        
        NLRX1 [cytosol] (Canis familiaris)
        
        NLRX1 [cytosol] (Canis familiaris)
- Innate Immune System (Canis familiaris)
  - Toll-like Receptor Cascades (Canis familiaris)
    - Toll Like Receptor 10 (TLR10) Cascade (Canis familiaris)
      - MyD88 cascade initiated on plasma membrane (Canis familiaris)
        
        TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
        
        Regulation of NF-kappa B signaling (Canis familiaris)
        
        NLRX1 binds CHUK:IKBKB:IKBKG (Canis familiaris)
        
        CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Canis familiaris)
        
        NLRX1 [cytosol] (Canis familiaris)
        
        NLRX1 [cytosol] (Canis familiaris)
    - Toll Like Receptor 2 (TLR2) Cascade (Canis familiaris)
      - Toll Like Receptor TLR1:TLR2 Cascade (Canis familiaris)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
        
        TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
        
        Regulation of NF-kappa B signaling (Canis familiaris)
        
        NLRX1 binds CHUK:IKBKB:IKBKG (Canis familiaris)
        
        CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Canis familiaris)
        
        NLRX1 [cytosol] (Canis familiaris)
        
        NLRX1 [cytosol] (Canis familiaris)
      - Toll Like Receptor TLR6:TLR2 Cascade (Canis familiaris)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
        
        TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
        
        Regulation of NF-kappa B signaling (Canis familiaris)
        
        NLRX1 binds CHUK:IKBKB:IKBKG (Canis familiaris)
        
        CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Canis familiaris)
        
        NLRX1 [cytosol] (Canis familiaris)
        
        NLRX1 [cytosol] (Canis familiaris)
    - Toll Like Receptor 3 (TLR3) Cascade (Canis familiaris)
      - TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
        
        Regulation of NF-kappa B signaling (Canis familiaris)
        
        NLRX1 binds CHUK:IKBKB:IKBKG (Canis familiaris)
        
        CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Canis familiaris)
        
        NLRX1 [cytosol] (Canis familiaris)
        
        NLRX1 [cytosol] (Canis familiaris)
    - Toll Like Receptor 4 (TLR4) Cascade (Canis familiaris)
      - MyD88-independent TLR4 cascade (Canis familiaris)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Canis familiaris)
        
        TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
        
        Regulation of NF-kappa B signaling (Canis familiaris)
        
        NLRX1 binds CHUK:IKBKB:IKBKG (Canis familiaris)
        
        CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Canis familiaris)
        
        NLRX1 [cytosol] (Canis familiaris)
        
        NLRX1 [cytosol] (Canis familiaris)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
        
        TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
        
        Regulation of NF-kappa B signaling (Canis familiaris)
        
        NLRX1 binds CHUK:IKBKB:IKBKG (Canis familiaris)
        
        CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Canis familiaris)
        
        NLRX1 [cytosol] (Canis familiaris)
        
        NLRX1 [cytosol] (Canis familiaris)
    - Toll Like Receptor 5 (TLR5) Cascade (Canis familiaris)
      - MyD88 cascade initiated on plasma membrane (Canis familiaris)
        
        TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
        
        Regulation of NF-kappa B signaling (Canis familiaris)
        
        NLRX1 binds CHUK:IKBKB:IKBKG (Canis familiaris)
        
        CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Canis familiaris)
        
        NLRX1 [cytosol] (Canis familiaris)
        
        NLRX1 [cytosol] (Canis familiaris)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Canis familiaris)
      - MyD88 dependent cascade initiated on endosome (Canis familiaris)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
        
        TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
        
        Regulation of NF-kappa B signaling (Canis familiaris)
        
        NLRX1 binds CHUK:IKBKB:IKBKG (Canis familiaris)
        
        CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Canis familiaris)
        
        NLRX1 [cytosol] (Canis familiaris)
        
        NLRX1 [cytosol] (Canis familiaris)
    - Toll Like Receptor 9 (TLR9) Cascade (Canis familiaris)
      - MyD88 dependent cascade initiated on endosome (Canis familiaris)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
        
        TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
        
        Regulation of NF-kappa B signaling (Canis familiaris)
        
        NLRX1 binds CHUK:IKBKB:IKBKG (Canis familiaris)
        
        CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Canis familiaris)
        
        NLRX1 [cytosol] (Canis familiaris)
        
        NLRX1 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3NRJ3

Gene Names

NLRX1

Reference Genes

BioGPS Gene:489370 NLRX1

ENSEMBL:ENSCAFG00845014678.1

KEGG:cfa:489370 NLRX1

Monarch:489370 NLRX1

NCBI Gene:489370 NLRX1

UCSC:A0A8I3NRJ3 NLRX1

Reference Transcript

Other Identifiers

489370

Cfa.12412.1.A1_at

CfaAffx.18737.1.S1_at

CfaAffx.18939.1.S1_at

GO:0005739

GO:0005886

GO:0010936

GO:0032688

GO:0032715

GO:0039536

GO:0043124

GO:0043226

GO:0045824

GO:0050728

Participates

as an input of

NLRX1 binds CHUK:IKBKB:IKBKG (Canis familiaris)

as a component of

CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Canis familiaris)

Other forms of this molecule

NLRX1 [mitochondrial outer membrane]

Inferred From

K63polyUb-NLRX1 [cytosol] (Homo sapiens)

Modified Residues

Name

ubiquitinylated lysine (K63polyUb [cytosol]) at unknown position

Modification

K63polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

XP_013968846.1, XP_013968845.1, XP_546488.3

ENSEMBL

ENSCAFT00845026274, ENSCAFP00845020714

Cite Us!