Reactome | K6PolyUb,p-5S-BRCA1:K6PolyUb,p-2T-BARD1 [nucleoplasm]

K6PolyUb,p-5S-BRCA1:K6PolyUb,p-2T-BARD1 [nucleoplasm]

Stable Identifier

R-CFA-9707288

Type

Complex

Species

Canis familiaris

Compartment

nucleoplasm

Locations in the PathwayBrowser

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Cell Cycle (Canis familiaris)

- Cell Cycle Checkpoints (Canis familiaris)
  - G2/M Checkpoints (Canis familiaris)
    - G2/M DNA damage checkpoint (Canis familiaris)
      - CHEK2 is recruited to DNA DSBs (Canis familiaris)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Canis familiaris)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Canis familiaris)
        
        p-S1387,S1423,S1457,S1524-BRCA1:p-T714,T734-BARD1 [nucleoplasm] (Canis familiaris)
        
        K6PolyUb,p-5S-BRCA1:K6PolyUb,p-2T-BARD1 [nucleoplasm] (Canis familiaris)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Canis familiaris)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Canis familiaris)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Canis familiaris)
        
        p-S1387,S1423,S1457,S1524-BRCA1:p-T714,T734-BARD1 [nucleoplasm] (Canis familiaris)
        
        K6PolyUb,p-5S-BRCA1:K6PolyUb,p-2T-BARD1 [nucleoplasm] (Canis familiaris)
      - Phosphorylation and activation of CHEK2 by ATM (Canis familiaris)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Canis familiaris)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Canis familiaris)
        
        p-S1387,S1423,S1457,S1524-BRCA1:p-T714,T734-BARD1 [nucleoplasm] (Canis familiaris)
        
        K6PolyUb,p-5S-BRCA1:K6PolyUb,p-2T-BARD1 [nucleoplasm] (Canis familiaris)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Canis familiaris)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Canis familiaris)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Canis familiaris)
        
        p-S1387,S1423,S1457,S1524-BRCA1:p-T714,T734-BARD1 [nucleoplasm] (Canis familiaris)
        
        K6PolyUb,p-5S-BRCA1:K6PolyUb,p-2T-BARD1 [nucleoplasm] (Canis familiaris)

DNA Repair (Canis familiaris)

- DNA Double-Strand Break Repair (Canis familiaris)
  - DNA Double Strand Break Response (Canis familiaris)
    - Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Canis familiaris)
      - CHEK2 is recruited to DNA DSBs (Canis familiaris)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Canis familiaris)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Canis familiaris)
        
        p-S1387,S1423,S1457,S1524-BRCA1:p-T714,T734-BARD1 [nucleoplasm] (Canis familiaris)
        
        K6PolyUb,p-5S-BRCA1:K6PolyUb,p-2T-BARD1 [nucleoplasm] (Canis familiaris)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Canis familiaris)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Canis familiaris)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Canis familiaris)
        
        p-S1387,S1423,S1457,S1524-BRCA1:p-T714,T734-BARD1 [nucleoplasm] (Canis familiaris)
        
        K6PolyUb,p-5S-BRCA1:K6PolyUb,p-2T-BARD1 [nucleoplasm] (Canis familiaris)
      - CHEK2 phosphorylates BRCA1 (Canis familiaris)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Canis familiaris)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Canis familiaris)
        
        p-S1387,S1423,S1457,S1524-BRCA1:p-T714,T734-BARD1 [nucleoplasm] (Canis familiaris)
        
        K6PolyUb,p-5S-BRCA1:K6PolyUb,p-2T-BARD1 [nucleoplasm] (Canis familiaris)
      - Phosphorylation and activation of CHEK2 by ATM (Canis familiaris)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Canis familiaris)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Canis familiaris)
        
        p-S1387,S1423,S1457,S1524-BRCA1:p-T714,T734-BARD1 [nucleoplasm] (Canis familiaris)
        
        K6PolyUb,p-5S-BRCA1:K6PolyUb,p-2T-BARD1 [nucleoplasm] (Canis familiaris)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Canis familiaris)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Canis familiaris)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Canis familiaris)
        
        p-S1387,S1423,S1457,S1524-BRCA1:p-T714,T734-BARD1 [nucleoplasm] (Canis familiaris)
        
        K6PolyUb,p-5S-BRCA1:K6PolyUb,p-2T-BARD1 [nucleoplasm] (Canis familiaris)
      - Phosphorylation of BRCA1-A complex at multiple sites by ATM (Canis familiaris)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Canis familiaris)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Canis familiaris)
        
        p-S1387,S1423,S1457,S1524-BRCA1:p-T714,T734-BARD1 [nucleoplasm] (Canis familiaris)
        
        K6PolyUb,p-5S-BRCA1:K6PolyUb,p-2T-BARD1 [nucleoplasm] (Canis familiaris)

General

This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Participants

components

Participates

as a member of

p-S1387,S1423,S1457,S1524-BRCA1:p-T714,T734-BARD1 [nucleoplasm] (Canis familiaris)

Inferred From

K6PolyUb,p-5S-BRCA1:K6PolyUb,p-2T-BARD1 [nucleoplasm] (Homo sapiens)

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