Reactome | UPF3A [cytosol]

UPF3A [cytosol]

Stable Identifier

R-CFA-927801

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

E2R5F4

Locations in the PathwayBrowser

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Metabolism of RNA (Canis familiaris)

- Nonsense-Mediated Decay (NMD) (Canis familiaris)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Canis familiaris)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Canis familiaris)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Canis familiaris)
        
        UPF3 [cytosol] (Canis familiaris)
        
        UPF3A [cytosol] (Canis familiaris)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Canis familiaris)
        
        UPF3 [cytosol] (Canis familiaris)
        
        UPF3A [cytosol] (Canis familiaris)
    - SMG6 hydrolyzes mRNA with premature termination codon (Canis familiaris)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Canis familiaris)
        
        UPF3 [cytosol] (Canis familiaris)
        
        UPF3A [cytosol] (Canis familiaris)
        
        UPF3A [cytosol] (Canis familiaris)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Canis familiaris)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Canis familiaris)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Canis familiaris)
        
        UPF3 [cytosol] (Canis familiaris)
        
        UPF3A [cytosol] (Canis familiaris)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Canis familiaris)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Canis familiaris)
        
        UPF3 [cytosol] (Canis familiaris)
        
        UPF3A [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:E2R5F4

Reference Genes

ENSEMBL:ENSCAFG00000006504

Other Identifiers

607836

AAEX03013416

Cfa.10460.1.A1_at

CfaAffx.10715.1.S1_s_at

ENSCAFG00000006504

ENSCAFP00000009736

ENSCAFT00000010502

EntrezGene:607836

EntrezGene:UPF3A

GO:0000184

GO:0003674

GO:0003676

GO:0003677

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005730

GO:0005737

GO:0005829

GO:0006412

GO:0008150

GO:0009056

GO:0009058

GO:0032991

GO:0034641

GO:0034655

GO:0035145

GO:0042162

GO:0043226

GO:0043231

GO:0045727

IPR005120

IPR012677

IPR034978

IPR035979

IPR039722

PF03467

UPF3A

UPF3A-201

UPI0002749C3B

VGNC:48152

XM_005634140

XM_005634141

XM_844659

XP_005634198

XP_849752

XR_295267

XR_295268

XR_295269

XR_295270

Participant Of

hasComponent

Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol]

hasMember

UPF3 [cytosol]

Inferred From

UPF3A [cytosol] (Homo sapiens)

UPF3AS-2 [cytosol] (Homo sapiens)