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What is Reactome ?
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Digital Preservation
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IL5 homodimer [extracellular region]
Stable Identifier
R-CFA-913383
Type
Complex
Species
Canis familiaris
Compartment
extracellular region
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
Signaling by Interleukins (Canis familiaris)
Interleukin-2 family signaling (Canis familiaris)
Interleukin receptor SHC signaling (Canis familiaris)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Canis familiaris)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5 homodimer [extracellular region] (Canis familiaris)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5 homodimer [extracellular region] (Canis familiaris)
Phosphorylated SHC recruits GRB2:SOS1 (Canis familiaris)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5 homodimer [extracellular region] (Canis familiaris)
Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5 homodimer [extracellular region] (Canis familiaris)
Phosphorylated SHC1 recruits GRB2:GAB2 (Canis familiaris)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5 homodimer [extracellular region] (Canis familiaris)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5 homodimer [extracellular region] (Canis familiaris)
Phosphorylated SHC1 recruits SHIP (Canis familiaris)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5 homodimer [extracellular region] (Canis familiaris)
Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Canis familiaris)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5 homodimer [extracellular region] (Canis familiaris)
SHC1 mediates cytokine-induced phosphorylation of GAB2 (Canis familiaris)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5 homodimer [extracellular region] (Canis familiaris)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5 homodimer [extracellular region] (Canis familiaris)
The SHC1:SHIP1 complex is stabilized by GRB2 (Canis familiaris)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Canis familiaris)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5 homodimer [extracellular region] (Canis familiaris)
Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Canis familiaris)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Canis familiaris)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5 homodimer [extracellular region] (Canis familiaris)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Canis familiaris)
14-3-3 zeta binding allows recruitment of PI3K (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(S585)-Common beta chain [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(S585)-Common beta chain:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5 homodimer [extracellular region] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(S585)-Common beta chain [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(S585)-Common beta chain:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5 homodimer [extracellular region] (Canis familiaris)
Activation of STAT5a/b by JAK2 (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2:p-STAT5 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, activated JAK2:p-STAT5 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, p-JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5 homodimer [extracellular region] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc. activated JAK2:STAT5 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, activated JAK2:STAT5 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, p-JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5 homodimer [extracellular region] (Canis familiaris)
IL3RB is phosphorylated on Ser-585 (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:Common beta chain:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5 homodimer [extracellular region] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(S585)-Common beta chain [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(S585)-Common beta chain:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5 homodimer [extracellular region] (Canis familiaris)
Interleukin receptor SHC signaling (Canis familiaris)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Canis familiaris)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5 homodimer [extracellular region] (Canis familiaris)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5 homodimer [extracellular region] (Canis familiaris)
Phosphorylated SHC recruits GRB2:SOS1 (Canis familiaris)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5 homodimer [extracellular region] (Canis familiaris)
Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5 homodimer [extracellular region] (Canis familiaris)
Phosphorylated SHC1 recruits GRB2:GAB2 (Canis familiaris)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5 homodimer [extracellular region] (Canis familiaris)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5 homodimer [extracellular region] (Canis familiaris)
Phosphorylated SHC1 recruits SHIP (Canis familiaris)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5 homodimer [extracellular region] (Canis familiaris)
Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Canis familiaris)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5 homodimer [extracellular region] (Canis familiaris)
SHC1 mediates cytokine-induced phosphorylation of GAB2 (Canis familiaris)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5 homodimer [extracellular region] (Canis familiaris)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5 homodimer [extracellular region] (Canis familiaris)
The SHC1:SHIP1 complex is stabilized by GRB2 (Canis familiaris)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Canis familiaris)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5 homodimer [extracellular region] (Canis familiaris)
Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Canis familiaris)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Canis familiaris)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5 homodimer [extracellular region] (Canis familiaris)
Interleukin-5 is a homodimer (Canis familiaris)
IL5 homodimer [extracellular region] (Canis familiaris)
Interleukin-5 receptor alpha subunit binds Interleukin-5 (Canis familiaris)
IL5 homodimer [extracellular region] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5 homodimer [extracellular region] (Canis familiaris)
Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5 homodimer [extracellular region] (Canis familiaris)
IL5 homodimer:IL5RA:Common beta chain:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5 homodimer [extracellular region] (Canis familiaris)
JAK2 is phosphorylated, activated (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, p-JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5 homodimer [extracellular region] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:Common beta chain:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5 homodimer [extracellular region] (Canis familiaris)
Recruitment of SHC1 is mediated by Y593 of the common beta chain (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5 homodimer [extracellular region] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc:SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5 homodimer [extracellular region] (Canis familiaris)
SHP1 and SHP2 bind the common beta chain (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5 homodimer [extracellular region] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5 homodimer [extracellular region] (Canis familiaris)
SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593)-Bc:SHP1, SHP2 [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593)-Bc [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5 homodimer [extracellular region] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5 homodimer [extracellular region] (Canis familiaris)
STAT5 is recruited by JAK2 (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, p-JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5 homodimer [extracellular region] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc. activated JAK2:STAT5 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, activated JAK2:STAT5 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, p-JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5 homodimer [extracellular region] (Canis familiaris)
The receptor is activated (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:Common beta chain:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5 homodimer [extracellular region] (Canis familiaris)
High affinity binding complexes of interleukin receptors using the Common beta chain [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:Common beta chain:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5 homodimer [extracellular region] (Canis familiaris)
Tyrosine kinases phosphorylate the receptor (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:Common beta chain:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5 homodimer [extracellular region] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5 homodimer [extracellular region] (Canis familiaris)
Tyrosine kinases that phosphorylate the Common beta chain [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:Common beta chain:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5 homodimer [extracellular region] (Canis familiaris)
IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5 homodimer [extracellular region] (Canis familiaris)
p-S585-IL3RB binds 14-3-3 proteins (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(S585)-Common beta chain [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(S585)-Common beta chain:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5 homodimer [extracellular region] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(S585)-Common beta chain [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(S585)-Common beta chain:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5 homodimer [extracellular region] (Canis familiaris)
p-STAT5 dissociates from the receptor complex (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, p-JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5 homodimer [extracellular region] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2:p-STAT5 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, activated JAK2:p-STAT5 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, p-JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:Common beta chain:p-JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5 homodimer [extracellular region] (Canis familiaris)
Signal Transduction (Canis familiaris)
MAPK family signaling cascades (Canis familiaris)
MAPK1/MAPK3 signaling (Canis familiaris)
RAF/MAP kinase cascade (Canis familiaris)
RAS GEFs promote RAS nucleotide exchange (Canis familiaris)
RAS GEFs [plasma membrane] (Canis familiaris)
Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Canis familiaris)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Canis familiaris)
High affinity IL-5 receptor complex dimer, inactive JAK2, p(Y593, 628)-Bc [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA:p(Y593, 628)-Bc:JAK2 [plasma membrane] (Canis familiaris)
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
IL5 homodimer [extracellular region] (Canis familiaris)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
x 2
IL5 [extracellular region]
(Canis familiaris)
Participates
as an input of
Interleukin-5 receptor alpha subunit binds Interleukin-5 (Canis familiaris)
as an output of
Interleukin-5 is a homodimer (Canis familiaris)
as a component of
IL5 homodimer:IL5RA [plasma membrane] (Canis familiaris)
Inferred From
IL5 homodimer [extracellular region]
(Homo sapiens)
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