Reactome | COMMD7 [cytosol]

COMMD7 [cytosol]

Stable Identifier

R-CFA-8955104

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

COMMD7, A0A8I3PP17

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Canis familiaris)

- Post-translational protein modification (Canis familiaris)
  - Neddylation (Canis familiaris)
    - 26S proteasome degrades HIFalpha (Canis familiaris)
      - RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
        
        COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs [cytosol] (Canis familiaris)
        
        COMMD7 [cytosol] (Canis familiaris)
      - ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
        
        RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
        
        COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs [cytosol] (Canis familiaris)
        
        COMMD7 [cytosol] (Canis familiaris)
    - AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Canis familiaris)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs [cytosol] (Canis familiaris)
        
        COMMD7 [cytosol] (Canis familiaris)
      - NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs [cytosol] (Canis familiaris)
        
        COMMD7 [cytosol] (Canis familiaris)
    - AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Canis familiaris)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Canis familiaris)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs [cytosol] (Canis familiaris)
        
        COMMD7 [cytosol] (Canis familiaris)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs [cytosol] (Canis familiaris)
        
        COMMD7 [cytosol] (Canis familiaris)
      - NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs [cytosol] (Canis familiaris)
        
        COMMD7 [cytosol] (Canis familiaris)
    - AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Canis familiaris)
      - NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs [cytosol] (Canis familiaris)
        
        COMMD7 [cytosol] (Canis familiaris)
      - NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
        
        COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs [cytosol] (Canis familiaris)
        
        COMMD7 [cytosol] (Canis familiaris)
    - AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Canis familiaris)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs [cytosol] (Canis familiaris)
        
        COMMD7 [cytosol] (Canis familiaris)
      - NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
        
        COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs [cytosol] (Canis familiaris)
        
        COMMD7 [cytosol] (Canis familiaris)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Canis familiaris)
      - COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs [cytosol] (Canis familiaris)
        
        COMMD7 [cytosol] (Canis familiaris)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs [cytosol] (Canis familiaris)
        
        COMMD7 [cytosol] (Canis familiaris)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs [cytosol] (Canis familiaris)
        
        COMMD7 [cytosol] (Canis familiaris)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs [cytosol] (Canis familiaris)
        
        COMMD7 [cytosol] (Canis familiaris)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs [cytosol] (Canis familiaris)
        
        COMMD7 [cytosol] (Canis familiaris)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Canis familiaris)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs [cytosol] (Canis familiaris)
        
        COMMD7 [cytosol] (Canis familiaris)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
        
        COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs [cytosol] (Canis familiaris)
        
        COMMD7 [cytosol] (Canis familiaris)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
        
        COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs [cytosol] (Canis familiaris)
        
        COMMD7 [cytosol] (Canis familiaris)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs [cytosol] (Canis familiaris)
        
        COMMD7 [cytosol] (Canis familiaris)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs [cytosol] (Canis familiaris)
        
        COMMD7 [cytosol] (Canis familiaris)
        
        NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
        
        COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs [cytosol] (Canis familiaris)
        
        COMMD7 [cytosol] (Canis familiaris)
        
        NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
        
        COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs [cytosol] (Canis familiaris)
        
        COMMD7 [cytosol] (Canis familiaris)
        
        NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs [cytosol] (Canis familiaris)
        
        COMMD7 [cytosol] (Canis familiaris)
    - MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Canis familiaris)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Canis familiaris)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs [cytosol] (Canis familiaris)
        
        COMMD7 [cytosol] (Canis familiaris)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs [cytosol] (Canis familiaris)
        
        COMMD7 [cytosol] (Canis familiaris)
    - NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Canis familiaris)
      - CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs [cytosol] (Canis familiaris)
        
        COMMD7 [cytosol] (Canis familiaris)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs [cytosol] (Canis familiaris)
        
        COMMD7 [cytosol] (Canis familiaris)
    - NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Canis familiaris)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs [cytosol] (Canis familiaris)
        
        COMMD7 [cytosol] (Canis familiaris)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs [cytosol] (Canis familiaris)
        
        COMMD7 [cytosol] (Canis familiaris)
    - NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Canis familiaris)
      - CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs [cytosol] (Canis familiaris)
        
        COMMD7 [cytosol] (Canis familiaris)
      - NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs [cytosol] (Canis familiaris)
        
        COMMD7 [cytosol] (Canis familiaris)
    - NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Canis familiaris)
      - CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs [cytosol] (Canis familiaris)
        
        COMMD7 [cytosol] (Canis familiaris)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs [cytosol] (Canis familiaris)
        
        COMMD7 [cytosol] (Canis familiaris)
    - VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Canis familiaris)
      - RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
        
        COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs [cytosol] (Canis familiaris)
        
        COMMD7 [cytosol] (Canis familiaris)
      - RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Canis familiaris)
        
        RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
        
        COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs [cytosol] (Canis familiaris)
        
        COMMD7 [cytosol] (Canis familiaris)
    - VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Canis familiaris)
      - RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7 [cytosol] (Canis familiaris)
        
        RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
        
        COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs [cytosol] (Canis familiaris)
        
        COMMD7 [cytosol] (Canis familiaris)
      - RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Canis familiaris)
        
        RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
        
        COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs [cytosol] (Canis familiaris)
        
        COMMD7 [cytosol] (Canis familiaris)
      - ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
        
        RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
        
        COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        COMMDs [cytosol] (Canis familiaris)
        
        COMMD7 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3PP17

Gene Names

COMMD7

Reference Genes

BioGPS Gene:612903 COMMD7

ENSEMBL:ENSCAFG00845021762.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845021762.1 COMMD7

Monarch:612903 COMMD7

NCBI Gene:612903 COMMD7

Reference Transcript

RefSeq:XM_847259.4 COMMD7

Other Identifiers

612903

Cfa.11261.1.A1_at

CfaAffx.11731.1.S1_at

GO:0006351

GO:0006355

GO:0023052

GO:0033209

GO:0045892

GO:0051059

Participates

as a candidate of

COMMDs [cytosol] (Canis familiaris)

Other forms of this molecule

COMMD7 [nucleoplasm]

Inferred From

COMMD7 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_852352.1

OpenTargets

ENSG00000149600

Ensembl

ENSCAFT00845038425, ENSCAFG00845021762, ENSCAFP00845030084

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