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CUL2 [cytosol]
Stable Identifier
R-CFA-8952511
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
G76-NEDD8-K689-CUL2, A0A8I3MEX6
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Canis familiaris)
Post-translational protein modification (Canis familiaris)
Neddylation (Canis familiaris)
26S proteasome degrades HIFalpha (Canis familiaris)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
CUL2 [cytosol] (Canis familiaris)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
CUL2 [cytosol] (Canis familiaris)
AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Canis familiaris)
NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
NEDD8-CRL2 E3 ligase complex [cytosol] (Canis familiaris)
CUL2 [cytosol] (Canis familiaris)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Canis familiaris)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
NEDD8-CRL2 E3 ligase complex [cytosol] (Canis familiaris)
CUL2 [cytosol] (Canis familiaris)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Canis familiaris)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
CUL2 [cytosol] (Canis familiaris)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Canis familiaris)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
CUL2 [cytosol] (Canis familiaris)
VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Canis familiaris)
CUL2 [cytosol] (Canis familiaris)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7 [cytosol] (Canis familiaris)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
CUL2 [cytosol] (Canis familiaris)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Canis familiaris)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
CUL2 [cytosol] (Canis familiaris)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
CUL2 [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3MEX6
Gene Names
CUL2
Reference Genes
ENSEMBL:ENSCAFG00845002080.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845002080.1 CUL2
Other Identifiers
477952
Cfa.19061.1.S1_s_at
Cfa.19886.1.A1_s_at
GO:0005634
GO:0005654
GO:0006511
GO:0016567
GO:0030163
GO:0031462
GO:0031625
GO:0036211
GO:0043226
GO:0140627
GO:0160072
Participates
as a component of
RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Canis familiaris)
NEDD8-CRL2 E3 ligase complex [cytosol] (Canis familiaris)
Other forms of this molecule
CUL2 [nucleoplasm]
CUL2 [cytosol]
Inferred From
G76-NEDD8-K689-CUL2 [cytosol]
(Homo sapiens)
Modified Residues
Name
neddylated lysine (monoNEDD8 [cytosol]) at 689 (in Homo sapiens)
Coordinate
689
Modification
monoNEDD8 [cytosol]
PsiMod Name
neddylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a nedd8 protein.
Cross References
OpenTargets
ENSG00000108094
Ensembl
ENSCAFP00845002960
,
ENSCAFG00845002080
,
ENSCAFT00845003725
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