Reactome | PTEN [cytosol]

PTEN [cytosol]

Stable Identifier

R-CFA-8948777

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

K48polyUb-K289-PTEN, P60483

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P60483

Gene Names

PTEN

Reference Genes

BioGPS Gene:403832 PTEN

ENSEMBL:ENSCAFG00030021263

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00030021263.1 PTEN

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00040023806.1 PTEN

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845029443.1 PTEN

KEGG Gene (Canis lupus familiaris):403832 PTEN

Monarch:403832 PTEN

NCBI Gene:403832 PTEN

Reference Transcript

RefSeq:NM_001003192.1 PTEN

Other Identifiers

403832

Cfa.10951.1.A1_at

Cfa.3695.1.S1_s_at

GO:0000278

GO:0001933

GO:0003824

GO:0004438

GO:0004721

GO:0004722

GO:0004725

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005886

GO:0006629

GO:0007010

GO:0007056

GO:0007059

GO:0007155

GO:0008285

GO:0009898

GO:0010719

GO:0010997

GO:0016311

GO:0016314

GO:0016324

GO:0016787

GO:0016791

GO:0019899

GO:0022414

GO:0023052

GO:0030154

GO:0030163

GO:0030165

GO:0030336

GO:0031647

GO:0033137

GO:0034330

GO:0036211

GO:0042060

GO:0042802

GO:0042995

GO:0043226

GO:0046856

GO:0048856

GO:0048870

GO:0050821

GO:0051548

GO:0051717

GO:0051800

GO:0051895

GO:0051898

GO:0052866

GO:0060070

GO:0071257

GO:0140013

GO:0140096

GO:1902807

GO:1903690

GO:1904706

GO:1990381

GO:2000060

GO:2000134

Participates

as a member of

PolyUb-PTEN, K48polyUb-K289-PTEN, PolyUb-K324,K344,K349-RibC-E40,E150,D326-PTEN [cytosol] (Canis familiaris)

as an output of

MKRN1 polyubiquitinates PTEN (Canis familiaris)

as an input of

USP13 and OTUD3 deubiquitinate PTEN (Canis familiaris)

Other forms of this molecule

PTEN [cytosol]

PTEN [nucleoplasm]

phospho-PTEN [cytosol]

PTEN [cytosol]

PTEN [nucleoplasm]

PTEN [cytosol]

phospho-PTEN [cytosol]

Inferred From

PolyUb-PTEN,K48polyUb-K289-PTEN [cytosol] (Homo sapiens)

K48polyUb-K289-PTEN [cytosol] (Homo sapiens)

Modified Residues

Name

ubiquitinylated lysine (K48polyUb [cytosol]) at 289 (in Homo sapiens)

Coordinate

289

Modification

K48polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_001003192.1

OpenTargets

ENSG00000171862

IntEnz

3.1.3.67, 3.1.3.48, 3.1.3.16

Ensembl

ENSCAFT00845052143, ENSCAFP00845040898, ENSCAFG00845029443