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PTEN [cytosol]
Stable Identifier
R-CFA-8948777
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
cytosol
Synonyms
K48polyUb-K289-PTEN, P60483
Locations in the PathwayBrowser
Expand all
Signal Transduction (Canis familiaris)
Intracellular signaling by second messengers (Canis familiaris)
PIP3 activates AKT signaling (Canis familiaris)
PTEN Regulation (Canis familiaris)
Regulation of PTEN stability and activity (Canis familiaris)
MKRN1 polyubiquitinates PTEN (Canis familiaris)
PTEN [cytosol] (Canis familiaris)
Proteasome degrades polyubiquitinated PTEN (Canis familiaris)
PolyUb-PTEN, K48polyUb-K289-PTEN, PolyUb-K324,K344,K349-RibC-E40,E150,D326-PTEN [cytosol] (Canis familiaris)
PTEN [cytosol] (Canis familiaris)
USP13 and OTUD3 deubiquitinate PTEN (Canis familiaris)
PTEN [cytosol] (Canis familiaris)
External Reference Information
External Reference
UniProt:P60483
Gene Names
PTEN
Reference Genes
BioGPS Gene:403832 PTEN
ENSEMBL:ENSCAFG00030021263
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00030021263 PTEN
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00040023806 PTEN
KEGG Gene (Canis lupus familiaris):403832 PTEN
Monarch:403832 PTEN
NCBI Gene:403832 PTEN
Reference Transcript
RefSeq:NM_001003192.1 PTEN
Other Identifiers
403832
Cfa.10951.1.A1_at
Cfa.3695.1.S1_s_at
GO:0000003
GO:0000278
GO:0000902
GO:0001525
GO:0001933
GO:0002902
GO:0003674
GO:0004438
GO:0004721
GO:0004722
GO:0004725
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005886
GO:0005975
GO:0006464
GO:0006470
GO:0006629
GO:0006810
GO:0006950
GO:0007009
GO:0007049
GO:0007155
GO:0007165
GO:0007267
GO:0007270
GO:0007416
GO:0007417
GO:0007507
GO:0007568
GO:0007611
GO:0007626
GO:0008150
GO:0008219
GO:0008283
GO:0008284
GO:0008285
GO:0009056
GO:0009058
GO:0009898
GO:0010719
GO:0010975
GO:0010997
GO:0016192
GO:0016311
GO:0016314
GO:0016324
GO:0016477
GO:0016791
GO:0019899
GO:0019901
GO:0021542
GO:0021700
GO:0021955
GO:0022607
GO:0030154
GO:0030165
GO:0030336
GO:0030534
GO:0031642
GO:0031647
GO:0032228
GO:0032286
GO:0032535
GO:0033032
GO:0033137
GO:0033555
GO:0034330
GO:0034641
GO:0035176
GO:0035749
GO:0036294
GO:0040007
GO:0040011
GO:0042254
GO:0042711
GO:0042802
GO:0042995
GO:0043005
GO:0043066
GO:0043220
GO:0043226
GO:0043491
GO:0043542
GO:0044281
GO:0045475
GO:0045736
GO:0045792
GO:0046621
GO:0046855
GO:0046856
GO:0048646
GO:0048679
GO:0048681
GO:0048738
GO:0048853
GO:0048854
GO:0048856
GO:0048870
GO:0050680
GO:0050771
GO:0050821
GO:0050877
GO:0051091
GO:0051548
GO:0051717
GO:0051726
GO:0051800
GO:0051895
GO:0051898
GO:0060024
GO:0060044
GO:0060070
GO:0060074
GO:0060134
GO:0060179
GO:0060291
GO:0060341
GO:0060736
GO:0060997
GO:0061002
GO:0061024
GO:0070373
GO:0070374
GO:0071257
GO:0071456
GO:0090071
GO:0090344
GO:0090394
GO:0097105
GO:0097107
GO:1902807
GO:1903690
GO:1903984
GO:1904668
GO:1904706
GO:1990381
GO:2000060
GO:2000134
GO:2000463
GO:2000808
GO:2001235
Participates
as a member of
PolyUb-PTEN, K48polyUb-K289-PTEN, PolyUb-K324,K344,K349-RibC-E40,E150,D326-PTEN [cytosol] (Canis familiaris)
as an output of
MKRN1 polyubiquitinates PTEN (Canis familiaris)
as an input of
USP13 and OTUD3 deubiquitinate PTEN (Canis familiaris)
Other forms of this molecule
PTEN [cytosol]
PTEN [nucleoplasm]
PTEN [cytosol]
PTEN [nucleoplasm]
PTEN [nucleoplasm]
PTEN [cytosol]
PTEN [cytosol]
PTEN [cytosol]
phospho-PTEN [cytosol]
phospho-PTEN [cytosol]
phospho-PTEN [cytosol]
phospho-PTEN [cytosol]
Inferred From
PolyUb-PTEN,K48polyUb-K289-PTEN [cytosol]
(Homo sapiens)
K48polyUb-K289-PTEN [cytosol]
(Homo sapiens)
Modified Residues
Name
ubiquitinylated lysine (K48polyUb [cytosol]) at 289 (in Homo sapiens)
Coordinate
289
Modification
K48polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_001003192.1
OpenTargets
ENSG00000171862
IntEnz
3.1.3.48
,
3.1.3.67
Ensembl
ENSCAFP00845040898
,
ENSCAFG00845029443
,
ENSCAFT00845052143
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