Reactome | VAMP8 [clathrin-coated endocytic vesicle membrane]

VAMP8 [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-CFA-8869137

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

VAMP8, E2QUL2

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Canis familiaris)

- Membrane Trafficking (Canis familiaris)
  - Clathrin-mediated endocytosis (Canis familiaris)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        VAMP8 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        VAMP8 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        VAMP8 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        VAMP8 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Canis familiaris)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        VAMP8 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        VAMP8 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
    - Dissociation of clathrin-associated proteins (Canis familiaris)
      - CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        VAMP8 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        VAMP8 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        VAMP8 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Canis familiaris)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        VAMP8 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        VAMP8 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
    - RAB5 and GAPVD1 bind AP-2 (Canis familiaris)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PICALM:VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        VAMP2,3,8 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        VAMP8 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:E2QUL2

Gene Names

VAMP8

Reference Genes

BioGPS Gene:609784 VAMP8

ENSEMBL:ENSCAFG00000007692

Monarch:609784 VAMP8

NCBI Gene:609784 VAMP8

Reference Transcript

RefSeq:XM_014120542.1 VAMP8

Other Identifiers

Cfa.4578.1.A1_s_at

Cfa.4578.1.A1_x_at

GO:0003674

GO:0005484

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005886

GO:0006810

GO:0006906

GO:0008150

GO:0016020

GO:0016021

GO:0016192

GO:0019905

GO:0022607

GO:0031201

GO:0031410

GO:0032991

GO:0035493

GO:0043226

GO:0061024

GO:0065003

GO:0070254

GO:0098594

Participant Of

hasMember

VAMP2,3,8 [clathrin-coated endocytic vesicle membrane]

Other forms of this molecule

VAMP8 [secretory granule membrane]

VAMP8 [cytoplasmic vesicle membrane]

VAMP8 [Golgi membrane]

VAMP8 [lysosomal membrane]

VAMP8 [azurophil granule membrane]

VAMP8 [tertiary granule membrane]

VAMP8 [plasma membrane]

VAMP8 [specific granule membrane]

Inferred From

VAMP8 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Cross References

RefSeq

XP_013976017.1

OpenTargets

ENSG00000118640

Ensembl

ENSCAFG00000007692, ENSCAFT00000012315, ENSCAFP00000011416

VGNC

48227