Reactome | SYT2 [clathrin-coated endocytic vesicle membrane]

SYT2 [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-CFA-8869116

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

SYT2, A0A8I3P087

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Canis familiaris)

- Membrane Trafficking (Canis familiaris)
  - Clathrin-mediated endocytosis (Canis familiaris)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT2 dimer [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT2 dimer [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT2 dimer [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT2 dimer [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Canis familiaris)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT2 dimer [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT2 dimer [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT2 dimer [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Canis familiaris)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT2 dimer [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT2 dimer [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
    - RAB5 and GAPVD1 bind AP-2 (Canis familiaris)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        STON2,1:SYT dimers [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT dimers [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT2 dimer [clathrin-coated endocytic vesicle membrane] (Canis familiaris)
        
        SYT2 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3P087

Gene Names

SYT2

Reference Genes

ENSEMBL:ENSCAFG00845015072.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845015072.1 SYT2

Other Identifiers

607132

CfaAffx.16398.1.S1_at

GO:0005509

GO:0016020

GO:0030154

GO:0030672

GO:0031410

GO:0043226

GO:0045202

GO:0046872

GO:0048856

GO:1903861

Participates

as a component of

SYT2 dimer [clathrin-coated endocytic vesicle membrane] (Canis familiaris)

Other forms of this molecule

SYT2 [plasma membrane]

Inferred From

SYT2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Cross References

OpenTargets

ENSG00000143858

Ensembl

ENSCAFG00845015072, ENSCAFT00845026951, ENSCAFP00845021216

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