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phospho-ERBB2 [plasma membrane]
Stable Identifier
R-CFA-8864079
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
plasma membrane
Synonyms
p-7Y,Y1112-ERBB2, A0A8I3NLT7
Locations in the PathwayBrowser
Expand all
Signal Transduction (Canis familiaris)
Intracellular signaling by second messengers (Canis familiaris)
PIP3 activates AKT signaling (Canis familiaris)
Negative regulation of the PI3K/AKT network (Canis familiaris)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activator:PI3K [plasma membrane] (Canis familiaris)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Canis familiaris)
Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] (Canis familiaris)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Canis familiaris)
phospho-ERBB2 [plasma membrane] (Canis familiaris)
PI3K phosphorylates PIP2 to PIP3 (Canis familiaris)
Activator:PI3K [plasma membrane] (Canis familiaris)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Canis familiaris)
Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] (Canis familiaris)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Canis familiaris)
phospho-ERBB2 [plasma membrane] (Canis familiaris)
MAPK family signaling cascades (Canis familiaris)
MAPK1/MAPK3 signaling (Canis familiaris)
RAF/MAP kinase cascade (Canis familiaris)
RAS GEFs promote RAS nucleotide exchange (Canis familiaris)
RAS GEFs [plasma membrane] (Canis familiaris)
EGF:p-EGFR:p-ERBB2:GRB2:SOS1 [plasma membrane] (Canis familiaris)
Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] (Canis familiaris)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Canis familiaris)
phospho-ERBB2 [plasma membrane] (Canis familiaris)
GRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Canis familiaris)
p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Canis familiaris)
p-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Canis familiaris)
phospho-ERBB2 [plasma membrane] (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by ERBB2 (Canis familiaris)
Downregulation of ERBB2 signaling (Canis familiaris)
MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Canis familiaris)
p-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Canis familiaris)
phospho-ERBB2 [plasma membrane] (Canis familiaris)
p-ERBB2 heterodimers:MATK [plasma membrane] (Canis familiaris)
p-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Canis familiaris)
phospho-ERBB2 [plasma membrane] (Canis familiaris)
PTPN12 dephosphorylates ERBB2 on tyrosine Y1248 (Canis familiaris)
p-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Canis familiaris)
phospho-ERBB2 [plasma membrane] (Canis familiaris)
PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248 (Canis familiaris)
Phosphorylated ERBB2:EGFR heterodimers:PTPN18 [plasma membrane] (Canis familiaris)
Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] (Canis familiaris)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Canis familiaris)
phospho-ERBB2 [plasma membrane] (Canis familiaris)
ERBB2 Regulates Cell Motility (Canis familiaris)
MEMO1 binds RHOA:GTP:DIAPH1 (Canis familiaris)
p-ERBB2 heterodimers:MEMO1 [plasma membrane] (Canis familiaris)
p-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Canis familiaris)
phospho-ERBB2 [plasma membrane] (Canis familiaris)
p-ERBB2 heterodimers:MEMO1:RHOA:GTP:DIAPH1 [plasma membrane] (Canis familiaris)
p-ERBB2 heterodimers:MEMO1 [plasma membrane] (Canis familiaris)
p-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Canis familiaris)
phospho-ERBB2 [plasma membrane] (Canis familiaris)
Phosphorylated ERBB2 heterodimers bind MEMO1 (Canis familiaris)
p-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Canis familiaris)
phospho-ERBB2 [plasma membrane] (Canis familiaris)
p-ERBB2 heterodimers:MEMO1 [plasma membrane] (Canis familiaris)
p-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Canis familiaris)
phospho-ERBB2 [plasma membrane] (Canis familiaris)
PI3K events in ERBB2 signaling (Canis familiaris)
Binding of GRB2:GAB1 to p-ERBB2:p-EGFR (Canis familiaris)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Canis familiaris)
Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] (Canis familiaris)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Canis familiaris)
phospho-ERBB2 [plasma membrane] (Canis familiaris)
Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] (Canis familiaris)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Canis familiaris)
phospho-ERBB2 [plasma membrane] (Canis familiaris)
Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Canis familiaris)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Canis familiaris)
Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] (Canis familiaris)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Canis familiaris)
phospho-ERBB2 [plasma membrane] (Canis familiaris)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Canis familiaris)
Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] (Canis familiaris)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Canis familiaris)
phospho-ERBB2 [plasma membrane] (Canis familiaris)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Canis familiaris)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Canis familiaris)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PIK3R1 [plasma membrane] (Canis familiaris)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1 [plasma membrane] (Canis familiaris)
Phosphorylated ERBB2:EGFR heterodimers [plasma membrane] (Canis familiaris)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Canis familiaris)
phospho-ERBB2 [plasma membrane] (Canis familiaris)
SHC1 events in ERBB2 signaling (Canis familiaris)
SHC1 phosphorylation by ERBB2 heterodimers (Canis familiaris)
SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Canis familiaris)
p-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Canis familiaris)
phospho-ERBB2 [plasma membrane] (Canis familiaris)
p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Canis familiaris)
p-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Canis familiaris)
phospho-ERBB2 [plasma membrane] (Canis familiaris)
Trans-autophosphorylation of p-Y877-ERBB2 heterodimers (Canis familiaris)
Autophosphorylated p-Y877-ERBB2 heterodimers [plasma membrane] (Canis familiaris)
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Canis familiaris)
phospho-ERBB2 [plasma membrane] (Canis familiaris)
External Reference Information
External Reference
UniProt:A0A8I3NLT7
Gene Names
ERBB2
Reference Genes
ENSEMBL:ENSCAFG00845011735.1
ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845011735.1 ERBB2
Other Identifiers
403883
Cfa.3747.1.S1_s_at
GO:0000166
GO:0001042
GO:0001934
GO:0002116
GO:0002376
GO:0003824
GO:0004672
GO:0004713
GO:0004714
GO:0004888
GO:0005102
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005768
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006468
GO:0006886
GO:0007155
GO:0007165
GO:0007166
GO:0007169
GO:0007399
GO:0007422
GO:0007507
GO:0007528
GO:0008045
GO:0010008
GO:0010628
GO:0014044
GO:0015026
GO:0016020
GO:0016301
GO:0016310
GO:0016323
GO:0016324
GO:0016740
GO:0019838
GO:0023052
GO:0030154
GO:0030307
GO:0030971
GO:0031410
GO:0031594
GO:0032886
GO:0033080
GO:0033088
GO:0034330
GO:0035025
GO:0035556
GO:0036211
GO:0038127
GO:0038133
GO:0038134
GO:0038135
GO:0038143
GO:0042060
GO:0042127
GO:0042552
GO:0042734
GO:0042802
GO:0043125
GO:0043209
GO:0043226
GO:0043235
GO:0043491
GO:0045727
GO:0045785
GO:0045943
GO:0046982
GO:0048709
GO:0048856
GO:0050679
GO:0060089
GO:0070372
GO:0071363
GO:0071364
GO:0071526
GO:0090314
GO:0098590
GO:0099645
GO:0140096
Participates
as a component of
EGF:p-6Y-EGFR:p-7Y,Y1112-ERBB2 [plasma membrane] (Canis familiaris)
Other forms of this molecule
phospho-ERBB2 [plasma membrane]
phospho-ERBB2 [plasma membrane]
phospho-ERBB2 [plasma membrane]
phospho-ERBB2 [plasma membrane]
ERBB2 [plasma membrane]
phospho-ERBB2 [plasma membrane]
phospho-ERBB2 [plasma membrane]
phospho-ERBB2 [plasma membrane]
phospho-ERBB2 [plasma membrane]
phospho-ERBB2 [plasma membrane]
phospho-ERBB2 [plasma membrane]
Inferred From
p-7Y,Y1112-ERBB2 [plasma membrane]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at 1023 (in Homo sapiens)
Coordinate
1023
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1112 (in Homo sapiens)
Coordinate
1112
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1139 (in Homo sapiens)
Coordinate
1139
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1196 (in Homo sapiens)
Coordinate
1196
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1221 (in Homo sapiens)
Coordinate
1221
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1222 (in Homo sapiens)
Coordinate
1222
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1248 (in Homo sapiens)
Coordinate
1248
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 877 (in Homo sapiens)
Coordinate
877
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
OpenTargets
ENSG00000141736
Ensembl
ENSCAFT00845021300
,
ENSCAFG00845011735
,
ENSCAFP00845016751
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