Reactome | FBXW12 [cytosol]

FBXW12 [cytosol]

Stable Identifier

R-CFA-8862614

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

FBXW12, A0A8I3RTI2

Locations in the PathwayBrowser

Expand all

Immune System (Canis familiaris)

- Adaptive Immune System (Canis familiaris)
  - Class I MHC mediated antigen processing & presentation (Canis familiaris)
    - Antigen processing: Ubiquitination & Proteasome degradation (Canis familiaris)
      - Interaction of E3 with substrate and E2-Ub complex (Canis familiaris)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Canis familiaris)
        
        E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
        
        SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXW12 [cytosol] (Canis familiaris)
        
        E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
        
        SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXW12 [cytosol] (Canis familiaris)
      - Polyubiquitination of substrate (Canis familiaris)
        
        E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
        
        SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXW12 [cytosol] (Canis familiaris)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Canis familiaris)
        
        E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
        
        SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXW12 [cytosol] (Canis familiaris)
        
        E3:Ub:substrate [cytosol] (Canis familiaris)
        
        E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
        
        SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXW12 [cytosol] (Canis familiaris)
      - Release of E3 from polyubiquitinated substrate (Canis familiaris)
        
        E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
        
        SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXW12 [cytosol] (Canis familiaris)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Canis familiaris)
        
        E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
        
        SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXW12 [cytosol] (Canis familiaris)
      - Transfer of Ub from E2 to substrate and release of E2 (Canis familiaris)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Canis familiaris)
        
        E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
        
        SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXW12 [cytosol] (Canis familiaris)
        
        E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
        
        SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXW12 [cytosol] (Canis familiaris)
        
        E3:Ub:substrate [cytosol] (Canis familiaris)
        
        E3 ligases in proteasomal degradation [cytosol] (Canis familiaris)
        
        SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXW12 [cytosol] (Canis familiaris)

Metabolism of proteins (Canis familiaris)

- Post-translational protein modification (Canis familiaris)
  - Neddylation (Canis familiaris)
    - AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Canis familiaris)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Canis familiaris)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXW12 [cytosol] (Canis familiaris)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXW12 [cytosol] (Canis familiaris)
      - NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXW12 [cytosol] (Canis familiaris)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Canis familiaris)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Canis familiaris)
        
        CRL E3 ubiquitin ligases [cytosol] (Canis familiaris)
        
        SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXW12 [cytosol] (Canis familiaris)
      - CRL E3 ubiquitin ligases [cytosol] (Canis familiaris)
        
        SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXW12 [cytosol] (Canis familiaris)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Canis familiaris)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Canis familiaris)
        
        CRL E3 ubiquitin ligases [cytosol] (Canis familiaris)
        
        SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXW12 [cytosol] (Canis familiaris)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXW12 [cytosol] (Canis familiaris)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Canis familiaris)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXW12 [cytosol] (Canis familiaris)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXW12 [cytosol] (Canis familiaris)
    - MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Canis familiaris)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Canis familiaris)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXW12 [cytosol] (Canis familiaris)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXW12 [cytosol] (Canis familiaris)
    - NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Canis familiaris)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXW12 [cytosol] (Canis familiaris)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Canis familiaris)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Canis familiaris)
        
        SCF E3 ubiquitin ligase [cytosol] (Canis familiaris)
        
        F-box protein [cytosol] (Canis familiaris)
        
        FBXW12 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3RTI2

Gene Names

FBXW12

Reference Genes

ENSEMBL:ENSCAFG00845006725.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845006725.1 FBXW12

Other Identifiers

484779

CfaAffx.19944.1.S1_at

GO:0005515

Participates

as a member of

F-box protein [cytosol] (Canis familiaris)

Inferred From

FBXW12 [cytosol] (Homo sapiens)

Cross References

OpenTargets

ENSG00000164049

Ensembl

ENSCAFG00845006725, ENSCAFP00845009335, ENSCAFT00845011962

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