Reactome | FCHO1 [cytosol]

FCHO1 [cytosol]

Stable Identifier

R-CFA-8862257

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

cytosol

Synonyms

FCHO1, A0A8I3PMU8

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Canis familiaris)

- Membrane Trafficking (Canis familiaris)
  - Clathrin-mediated endocytosis (Canis familiaris)
    - AAK1 phosphorylates AP-2 mu subunit at T156 (Canis familiaris)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Canis familiaris)
        
        FCHO1,2 dimer [cytosol] (Canis familiaris)
        
        FCHO1 dimer [cytosol] (Canis familiaris)
        
        FCHO1 [cytosol] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Canis familiaris)
        
        FCHO1,2 dimer [cytosol] (Canis familiaris)
        
        FCHO1 dimer [cytosol] (Canis familiaris)
        
        FCHO1 [cytosol] (Canis familiaris)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Canis familiaris)
        
        FCHO1,2 dimer [cytosol] (Canis familiaris)
        
        FCHO1 dimer [cytosol] (Canis familiaris)
        
        FCHO1 [cytosol] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Canis familiaris)
        
        FCHO1,2 dimer [cytosol] (Canis familiaris)
        
        FCHO1 dimer [cytosol] (Canis familiaris)
        
        FCHO1 [cytosol] (Canis familiaris)
    - Cargo recognition for clathrin-mediated endocytosis (Canis familiaris)
      - ARBB recruits GPCRs into clathrin-coated pits (Canis familiaris)
        
        ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Canis familiaris)
        
        FCHO1,2 dimer [cytosol] (Canis familiaris)
        
        FCHO1 dimer [cytosol] (Canis familiaris)
        
        FCHO1 [cytosol] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Canis familiaris)
        
        FCHO1,2 dimer [cytosol] (Canis familiaris)
        
        FCHO1 dimer [cytosol] (Canis familiaris)
        
        FCHO1 [cytosol] (Canis familiaris)
    - Clathrin recruits PIK3C2A (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Canis familiaris)
        
        FCHO1,2 dimer [cytosol] (Canis familiaris)
        
        FCHO1 dimer [cytosol] (Canis familiaris)
        
        FCHO1 [cytosol] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Canis familiaris)
        
        FCHO1,2 dimer [cytosol] (Canis familiaris)
        
        FCHO1 dimer [cytosol] (Canis familiaris)
        
        FCHO1 [cytosol] (Canis familiaris)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Canis familiaris)
        
        FCHO1,2 dimer [cytosol] (Canis familiaris)
        
        FCHO1 dimer [cytosol] (Canis familiaris)
        
        FCHO1 [cytosol] (Canis familiaris)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Canis familiaris)
      - FCHO1,2 dimer [cytosol] (Canis familiaris)
        
        FCHO1 dimer [cytosol] (Canis familiaris)
        
        FCHO1 [cytosol] (Canis familiaris)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Canis familiaris)
        
        FCHO1,2 dimer [cytosol] (Canis familiaris)
        
        FCHO1 dimer [cytosol] (Canis familiaris)
        
        FCHO1 [cytosol] (Canis familiaris)
    - Recruitment of AP-2 complex and clathrin (Canis familiaris)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Canis familiaris)
        
        FCHO1,2 dimer [cytosol] (Canis familiaris)
        
        FCHO1 dimer [cytosol] (Canis familiaris)
        
        FCHO1 [cytosol] (Canis familiaris)
      - PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1 [plasma membrane] (Canis familiaris)
        
        PI(4,5)P2:AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1 [plasma membrane] (Canis familiaris)
        
        FCHO1,2 dimer [cytosol] (Canis familiaris)
        
        FCHO1 dimer [cytosol] (Canis familiaris)
        
        FCHO1 [cytosol] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3PMU8

Gene Names

FCHO1

Reference Genes

ENSEMBL:ENSCAFG00845025423.1

ENSEMBL_canis_lupus_familiaris_GENE:ENSCAFG00845025423.1 FCHO1

Other Identifiers

476673

Cfa.18908.1.S1_s_at

CfaAffx.23399.1.S1_s_at

GO:0002376

GO:0005634

GO:0005654

GO:0005829

GO:0005886

GO:0005905

GO:0007155

GO:0016192

GO:0023052

GO:0035612

GO:0043226

GO:0048268

GO:0050852

GO:0050870

GO:0065003

GO:0072583

Participates

as a component of

FCHO1 dimer [cytosol] (Canis familiaris)

Inferred From

FCHO1 [cytosol] (Homo sapiens)

Cross References

OpenTargets

ENSG00000130475

Ensembl

ENSCAFG00845025423, ENSCAFP00845035876, ENSCAFT00845045715

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