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HMGB1 [extracellular region]
Stable Identifier
R-CFA-879382
Type
Protein [EntityWithAccessionedSequence]
Species
Canis familiaris
Compartment
extracellular region
Synonyms
Q6YKA4
Locations in the PathwayBrowser
Expand all
Immune System (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
Signaling by Interleukins (Canis familiaris)
Interleukin-1 family signaling (Canis familiaris)
Interleukin-1 signaling (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
NF-kappa-B complex is transported from cytosol to nucleus (Canis familiaris)
AGER ligands:AGER [plasma membrane] (Canis familiaris)
AGER ligands [extracellular region] (Canis familiaris)
HMGB1 [extracellular region] (Canis familiaris)
Innate Immune System (Canis familiaris)
Advanced glycosylation endproduct receptor signaling (Canis familiaris)
Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor (Canis familiaris)
AGER ligands [extracellular region] (Canis familiaris)
HMGB1 [extracellular region] (Canis familiaris)
AGER ligands:AGER [plasma membrane] (Canis familiaris)
AGER ligands [extracellular region] (Canis familiaris)
HMGB1 [extracellular region] (Canis familiaris)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Canis familiaris)
TRAF6 mediated NF-kB activation (Canis familiaris)
NF-kappa-B complex is transported from cytosol to nucleus (Canis familiaris)
AGER ligands:AGER [plasma membrane] (Canis familiaris)
AGER ligands [extracellular region] (Canis familiaris)
HMGB1 [extracellular region] (Canis familiaris)
Neutrophil degranulation (Canis familiaris)
Exocytosis of ficolin-rich granule lumen proteins (Canis familiaris)
Ficolin-rich granule lumen proteins [extracellular region] (Canis familiaris)
HMGB1 [extracellular region] (Canis familiaris)
Exocytosis of secretory granule lumen proteins (Canis familiaris)
Secretory granule lumen proteins [extracellular region] (Canis familiaris)
HMGB1 [extracellular region] (Canis familiaris)
Toll-like Receptor Cascades (Canis familiaris)
Toll Like Receptor 10 (TLR10) Cascade (Canis familiaris)
MyD88 cascade initiated on plasma membrane (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
NF-kappa-B complex is transported from cytosol to nucleus (Canis familiaris)
AGER ligands:AGER [plasma membrane] (Canis familiaris)
AGER ligands [extracellular region] (Canis familiaris)
HMGB1 [extracellular region] (Canis familiaris)
Toll Like Receptor 2 (TLR2) Cascade (Canis familiaris)
Toll Like Receptor TLR1:TLR2 Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
NF-kappa-B complex is transported from cytosol to nucleus (Canis familiaris)
AGER ligands:AGER [plasma membrane] (Canis familiaris)
AGER ligands [extracellular region] (Canis familiaris)
HMGB1 [extracellular region] (Canis familiaris)
Toll Like Receptor TLR6:TLR2 Cascade (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
NF-kappa-B complex is transported from cytosol to nucleus (Canis familiaris)
AGER ligands:AGER [plasma membrane] (Canis familiaris)
AGER ligands [extracellular region] (Canis familiaris)
HMGB1 [extracellular region] (Canis familiaris)
Toll Like Receptor 3 (TLR3) Cascade (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
NF-kappa-B complex is transported from cytosol to nucleus (Canis familiaris)
AGER ligands:AGER [plasma membrane] (Canis familiaris)
AGER ligands [extracellular region] (Canis familiaris)
HMGB1 [extracellular region] (Canis familiaris)
Toll Like Receptor 4 (TLR4) Cascade (Canis familiaris)
MyD88-independent TLR4 cascade (Canis familiaris)
TRIF (TICAM1)-mediated TLR4 signaling (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
NF-kappa-B complex is transported from cytosol to nucleus (Canis familiaris)
AGER ligands:AGER [plasma membrane] (Canis familiaris)
AGER ligands [extracellular region] (Canis familiaris)
HMGB1 [extracellular region] (Canis familiaris)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
NF-kappa-B complex is transported from cytosol to nucleus (Canis familiaris)
AGER ligands:AGER [plasma membrane] (Canis familiaris)
AGER ligands [extracellular region] (Canis familiaris)
HMGB1 [extracellular region] (Canis familiaris)
Toll Like Receptor 5 (TLR5) Cascade (Canis familiaris)
MyD88 cascade initiated on plasma membrane (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
NF-kappa-B complex is transported from cytosol to nucleus (Canis familiaris)
AGER ligands:AGER [plasma membrane] (Canis familiaris)
AGER ligands [extracellular region] (Canis familiaris)
HMGB1 [extracellular region] (Canis familiaris)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Canis familiaris)
MyD88 dependent cascade initiated on endosome (Canis familiaris)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
NF-kappa-B complex is transported from cytosol to nucleus (Canis familiaris)
AGER ligands:AGER [plasma membrane] (Canis familiaris)
AGER ligands [extracellular region] (Canis familiaris)
HMGB1 [extracellular region] (Canis familiaris)
Toll Like Receptor 9 (TLR9) Cascade (Canis familiaris)
MyD88 dependent cascade initiated on endosome (Canis familiaris)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Canis familiaris)
TAK1-dependent IKK and NF-kappa-B activation (Canis familiaris)
NF-kappa-B complex is transported from cytosol to nucleus (Canis familiaris)
AGER ligands:AGER [plasma membrane] (Canis familiaris)
AGER ligands [extracellular region] (Canis familiaris)
HMGB1 [extracellular region] (Canis familiaris)
Vesicle-mediated transport (Canis familiaris)
Binding and Uptake of Ligands by Scavenger Receptors (Canis familiaris)
Scavenging by Class B Receptors (Canis familiaris)
CD5L (AIM) binds damage-associated patterns (DAMPs) (Canis familiaris)
CD5L:DAMP ligand [extracellular region] (Canis familiaris)
DAMP ligand of CD5L [extracellular region] (Canis familiaris)
HMGB1 [extracellular region] (Canis familiaris)
DAMP ligand of CD5L [extracellular region] (Canis familiaris)
HMGB1 [extracellular region] (Canis familiaris)
External Reference Information
External Reference
UniProt:Q6YKA4
Reference Genes
BioGPS Gene:403170
ENSEMBL:ENSCAFG00845021967
KEGG:cfa:403170
Monarch:403170
NCBI Gene:403170
UCSC:Q6YKA4
Reference Transcript
RefSeq:XM_038434508.1
RefSeq:XM_038434506.1
RefSeq:NM_001002937.2
Other Identifiers
403170
Cfa.416.1.S1_at
Cfa.416.1.S1_s_at
CfaAffx.10841.1.S1_s_at
GO:0000122
GO:0000793
GO:0000976
GO:0001530
GO:0001654
GO:0001773
GO:0001786
GO:0001935
GO:0002218
GO:0002221
GO:0002250
GO:0002270
GO:0002281
GO:0002318
GO:0002376
GO:0002437
GO:0002643
GO:0002840
GO:0003677
GO:0003684
GO:0003690
GO:0003713
GO:0003714
GO:0003723
GO:0003725
GO:0003727
GO:0005125
GO:0005178
GO:0005576
GO:0005615
GO:0005634
GO:0005694
GO:0005737
GO:0005768
GO:0005769
GO:0005783
GO:0005793
GO:0005886
GO:0005980
GO:0006259
GO:0006281
GO:0006284
GO:0006310
GO:0006325
GO:0006351
GO:0006355
GO:0006366
GO:0006914
GO:0006935
GO:0006954
GO:0006974
GO:0007204
GO:0008289
GO:0008301
GO:0009986
GO:0010508
GO:0010858
GO:0016020
GO:0016192
GO:0016829
GO:0017053
GO:0017055
GO:0019958
GO:0030099
GO:0030154
GO:0030295
GO:0030324
GO:0031507
GO:0032425
GO:0032689
GO:0032727
GO:0032728
GO:0032731
GO:0032732
GO:0032733
GO:0032735
GO:0032755
GO:0032757
GO:0032760
GO:0033151
GO:0034137
GO:0034145
GO:0035711
GO:0035767
GO:0035868
GO:0042104
GO:0043005
GO:0043065
GO:0043226
GO:0043277
GO:0043371
GO:0043410
GO:0043536
GO:0043537
GO:0045063
GO:0045087
GO:0045089
GO:0045639
GO:0045819
GO:0045944
GO:0046330
GO:0046598
GO:0048018
GO:0048856
GO:0048870
GO:0051384
GO:0061629
GO:0070182
GO:0070374
GO:0071222
GO:0071639
GO:0090026
GO:0090303
GO:0097350
GO:0098542
GO:0098761
GO:0098772
GO:0140297
GO:1901224
GO:1902533
GO:1903672
GO:1905455
GO:1905564
GO:2000343
GO:2000426
GO:2000819
GO:2001200
Participates
as a member of
DAMP ligand of CD5L [extracellular region] (Canis familiaris)
Secretory granule lumen proteins [extracellular region] (Canis familiaris)
Ficolin-rich granule lumen proteins [extracellular region] (Canis familiaris)
AGER ligands [extracellular region] (Canis familiaris)
Other forms of this molecule
HMGB1 [secretory granule lumen]
HMGB1 [ficolin-1-rich granule lumen]
HMGB1 [nucleoplasm]
HC23,45-HMGB1 [extracellular region]
Inferred From
HMGB1 [extracellular region]
(Homo sapiens)
Cross References
RefSeq
XP_038290434.1
,
XP_038290436.1
,
NP_001002937.1
ENSEMBL
ENSCAFT00845038767
,
ENSCAFG00845021967
,
ENSCAFP00845030356
VGNC
59082
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